公开(公告)号：US10888657B2

公开(公告)日：2021-01-12

申请号：US13219403

申请日：2011-08-26

申请人： Azita Soltani ,  Raymond M. Wolniewcz, III ,  Brenton Nistal ,  Curtis Genstler ,  Robert L. Wilcox ,  Ronald L. Haas

发明人： Azita Soltani ,  Raymond M. Wolniewcz, III ,  Brenton Nistal ,  Curtis Genstler ,  Robert L. Wilcox ,  Ronald L. Haas

IPC分类号： A61B17/22 ,  A61B18/00 ,  A61B90/00 ,  A61M5/158 ,  A61H1/00

摘要： An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.

公开(公告)号：US20120059285A1

公开(公告)日：2012-03-08

申请号：US13219403

申请日：2011-08-26

申请人： Azita Soltani ,  Raymond M. Wolniewcz, III ,  Brenton Nistal ,  Curtis Genstler ,  Robert L. Wilcox ,  Ronald L. Haas

发明人： Azita Soltani ,  Raymond M. Wolniewcz, III ,  Brenton Nistal ,  Curtis Genstler ,  Robert L. Wilcox ,  Ronald L. Haas

IPC分类号： A61B17/22

摘要： An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.

摘要翻译： 具有用于流体输送和排液的腔的超声导管和超声源用于治疗脑内或脑室内出血。 在将导管插入血块之后，可以通过管腔将裂解药物输送到血块，同时向治疗部位施加超声波能量。 当血块溶解时，液化血块可以通过内腔抽真空来除去。

公开(公告)号：US07727178B2

公开(公告)日：2010-06-01

申请号：US11643471

申请日：2006-12-21

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

公开(公告)号：US08696612B2

公开(公告)日：2014-04-15

申请号：US13431798

申请日：2012-03-27

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61M25/00

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The ultrasonic catheter system comprises a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end, a fluid delivery lumen, at least one ultrasound radiating element positioned in the treatment zone, wiring electrically coupled to the at least one ultrasound radiating element and extending through the tubular body and terminating at a connector, and a control system comprising external circuitry and an isolation pod that is configured to be electrically connected to the connector, the isolation pod being positioned between the tubular body and the external system and comprising an isolation barrier and circuitry for driving the ultrasound radiating element.

摘要翻译： 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 超声导管系统包括管状体，其具有位于远端和近端之间的近端，远端和处理区，流体输送腔，位于治疗区中的至少一个超声波辐射元件，电耦合 到所述至少一个超声波辐射元件并且延伸穿过所述管状主体并且终止于连接器，以及包括外部电路的控制系统和被配置为电连接到所述连接器的隔离盒，所述隔离盒位于所述管状 主体和外部系统，并且包括用于驱动超声波辐射元件的隔离屏障和电路。

公开(公告)号：US20120253237A1

公开(公告)日：2012-10-04

申请号：US13431798

申请日：2012-03-27

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61N7/00 ,  A61M25/00

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The ultrasonic catheter system comprises a tubular body having a proximal end, a distal end and a treatment zone located between the distal end and the proximal end, a fluid delivery lumen, at least one ultrasound radiating element positioned in the treatment zone, wiring electrically coupled to the at least one ultrasound radiating element and extending through the tubular body and terminating at a connector, and a control system comprising external circuitry and an isolation pod that is configured to be electrically connected to the connector, the isolation pod being positioned between the tubular body and the external system and comprising an isolation barrier and circuitry for driving the ultrasound radiating element.

摘要翻译： 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 超声导管系统包括管状体，其具有位于远端和近端之间的近端，远端和处理区，流体输送腔，位于治疗区中的至少一个超声波辐射元件，电耦合 到所述至少一个超声波辐射元件并且延伸穿过所述管状主体并且终止于连接器，以及包括外部电路的控制系统和被配置为电连接到所述连接器的隔离盒，所述隔离盒位于所述管状 主体和外部系统，并且包括用于驱动超声波辐射元件的隔离屏障和电路。

公开(公告)号：US07828762B2

公开(公告)日：2010-11-09

申请号：US11643417

申请日：2006-12-21

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

摘要翻译： 用于将超声能量和治疗性化合物递送到患者脉管系统内的治疗部位的导管包括管状体。 管状体具有近端区域和与近端区域相对的远端区域。 导管还包括形成在管状体中的多个流体输送腔。 该导管还包括构造成用于插入管状体的内芯。 内芯包括具有多个扁平区域的细长电导体，每个扁平区域具有第一平坦侧和与第一平坦侧相对的第二平坦侧。 内芯还包括与细长电导体的扁平区域成对安装的多个超声波辐射构件。 第一超声波辐射构件安装到细长电导体的第一平坦侧，并且第二超声波辐射构件安装到细长电导体的第二平坦侧。 导管还包括配置成将驱动信号施加到超声辐射构件的至少两个但是少于全部的控制电子设备。

公开(公告)号：US08167831B2

公开(公告)日：2012-05-01

申请号：US12762254

申请日：2010-04-16

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A method of delivery ultrasonic energy and a therapeutic compound to a treatment site and an ultrasonic catheter system are disclosed. The method comprises providing a catheter with a plurality of ultrasound radiating members, wherein the plurality of ultrasound radiating members are allocated into electrical groups comprising more than one ultrasound radiating member. The method further comprises independently driving each group of ultrasonic radiating members, and delivering the therapeutic compound through the catheter to the treatment site.

摘要翻译： 公开了一种将超声能量和治疗化合物递送到治疗部位和超声波导管系统的方法。 该方法包括提供具有多个超声辐射构件的导管，其中多个超声辐射构件被分配成包括多于一个超声波辐射构件的电组。 该方法还包括独立地驱动每组超声辐射构件，并将治疗化合物通过导管输送到治疗部位。

公开(公告)号：US07220239B2

公开(公告)日：2007-05-22

申请号：US10309388

申请日：2002-12-03

申请人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

发明人： Richard R. Wilson ,  Robert L. Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Gerrit Barrere ,  Amy Cohen ,  George Keilman ,  Leonard R. Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

公开(公告)号：US20070112296A1

公开(公告)日：2007-05-17

申请号：US11643471

申请日：2006-12-21

申请人： Richard Wilson ,  Robert Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Barrere ,  Amy Cohen ,  George Keilman ,  Leonard Oliver ,  Natalya Peskin

发明人： Richard Wilson ,  Robert Wilcox ,  Curtis Genstler ,  Tim Abrahamson ,  Wm. Barrere ,  Amy Cohen ,  George Keilman ,  Leonard Oliver ,  Natalya Peskin

IPC分类号： A61B17/20

CPC分类号： A61M37/0092 ,  A61B17/2202 ,  A61B2017/22084 ,  A61B2017/22088 ,  A61M25/0029 ,  A61M25/0032 ,  A61N7/00 ,  A61N2007/0078

摘要： A catheter for delivering ultrasonic energy and therapeutic compounds to a treatment site within a patient's vasculature comprises a tubular body. The tubular body has a proximal region and a distal region opposite the proximal region. The catheter further comprises a plurality of fluid delivery lumens formed into the tubular body. The catheter further comprises an inner core configured for insertion into the tubular body. The inner core comprises an elongate electrical conductor having a plurality of flattened regions, each flattened region having a first flat side and a second flat side opposite the first flat side. The inner core further comprises a plurality of ultrasound radiating members mounted in pairs to the flattened regions of the elongate electrical conductor. A first ultrasound radiating member is mounted to the first flat side of the elongate electrical conductor, and a second ultrasound radiating member is mounted to the second flat side of the elongate electrical conductor. The catheter further comprises control electronics configured to apply a driving signal to at least two, but fewer than all, of the ultrasound radiating members.

公开(公告)号：US20120289889A1

公开(公告)日：2012-11-15

申请号：US13468920

申请日：2012-05-10

申请人： Curtis Genstler ,  Douglas R. Hansmann

发明人： Curtis Genstler ,  Douglas R. Hansmann

IPC分类号： A61M37/00

摘要： A catheter system for delivering ultrasonic energy to a treatment site within a body lumen, the catheter comprises a tubular body having a proximal end, a distal end and an energy delivery section positioned between the proximal end and the distal end and a plurality of ultrasound radiating members in the energy delivery section. The plurality of ultrasound radiating members are allocated into electrical groups comprising more than one ultrasound radiating member. Members of one electrical group are spatially interdigitated with members of another electrical group.

摘要翻译： 一种用于将超声能量输送到体腔内的治疗部位的导管系统，所述导管包括管状体，所述管状体具有近端，远端和位于所述近端和远端之间的能量输送部分，以及多个超声辐射 能源交付部门的成员。 多个超声波辐射构件被分配成包括多于一个的超声波辐射构件的电组。 一个电气组的成员与另一个电气组的成员在空间上相互交错。