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1.发明授权公开(公告)号：US09329186B2
公开(公告)日：2016-05-03
申请号：US12742377
申请日：2008-11-11
CPC分类号： G01N33/6812 , B01D15/3852 , B01J20/268 , C07K1/22 , G01N2600/00
摘要： The present invention relates to a method of separating or extracting phosphorylated amino acids, peptides or proteins with a molecularly imprinted polymer and to the preparation of said molecularly imprinted polymer as well as use of a molecularly imprinted polymer for separating or extracting phosphorylated amino acids, peptides or proteins.
摘要翻译： 本发明涉及用分子印迹聚合物分离或提取磷酸化氨基酸，肽或蛋白质的方法以及制备所述分子印迹聚合物以及使用分子印迹聚合物分离或提取磷酸化氨基酸，肽 或蛋白质。
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2.发明申请公开(公告)号：US20110015373A1
公开(公告)日：2011-01-20
申请号：US12742377
申请日：2008-11-11
IPC分类号： C07K1/14
CPC分类号： G01N33/6812 , B01D15/3852 , B01J20/268 , C07K1/22 , G01N2600/00
摘要： The present invention relates to a method of separating or extracting phosphorylated amino acids, peptides or proteins with a molecularly imprinted polymer and to the preparation of said molecularly imprinted polymer as well as use of a molecularly imprinted polymer for separating or extracting phosphorylated amino acids, peptides or proteins.
摘要翻译： 本发明涉及用分子印迹聚合物分离或提取磷酸化氨基酸，肽或蛋白质的方法以及制备所述分子印迹聚合物以及使用分子印迹聚合物分离或提取磷酸化氨基酸，肽 或蛋白质。
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公开(公告)号：US20100203001A1
公开(公告)日：2010-08-12
申请号：US12520670
申请日：2007-12-21
IPC分类号： A61K31/50 , C07C319/00 , C07K14/435 , C07K4/12 , A61K8/65 , A61K31/519 , A61K31/505 , A61K31/515 , A61K31/52 , A61K31/522 , A61K31/525 , A61K31/506 , A61Q5/04 , A61P17/12 , A61P17/14
CPC分类号： A61K8/19 , A61K8/4926 , A61K8/494 , A61K8/4953 , A61K8/496 , A61K8/4966 , A61K31/50 , A61K31/505 , A61K31/506 , A61K31/515 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/525 , A61Q5/00 , A61Q5/02 , A61Q5/04 , A61Q5/06 , A61Q5/12 , A61Q7/00 , A61Q19/00 , C07K1/1133
摘要： The present invention relates to an improved method of formation of disulfide bridges in substances bearing SH groups, in particular peptides, for example by formation of intramolecular disulfide bridges, in which a heterocyclic compound having at least one nitrogen atom (e.g. caffeine or a caffeine-like substance) is used for catalysis of the reaction. It was found, surprisingly, that addition of the heterocyclic substance increases both the yield and the purity of the product bearing disulfide bridges.
摘要翻译： 本发明涉及一种在含有SH基团的物质（特别是肽）中形成二硫键的改进方法，例如通过形成分子内二硫键，其中具有至少一个氮原子的杂环化合物（例如咖啡因或咖啡因 - 类物质）用于催化反应。 发现令人惊讶的是，添加杂环物质增加了带有二硫键的产物的产率和纯度。
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公开(公告)号：US20110189752A1
公开(公告)日：2011-08-04
申请号：US12991038
申请日：2009-05-06
申请人： Udo Haberl , Hans -Georg Frank , Andy Poetgens , Marco Emgenbroich , Andreas Rybka , Carola Schräder , Christoph Kannicht
发明人： Udo Haberl , Hans -Georg Frank , Andy Poetgens , Marco Emgenbroich , Andreas Rybka , Carola Schräder , Christoph Kannicht
IPC分类号： C12N9/96 , C07K2/00 , C07K14/755 , C07K14/53 , C07K14/535 , C07K14/54 , C07K14/575 , C07K14/505 , C07K19/00 , C08F8/32 , C07K1/107
摘要： A complex comprising at least one target protein and at least one binding molecule having a binding affinity for said target protein, wherein said molecule having a binding affinity is covalently or non-covalently bound to at least one water-soluble polymer
摘要翻译： 一种包含至少一种靶蛋白和至少一种对所述靶蛋白具有结合亲和力的结合分子的复合物，其中具有结合亲和力的所述分子与至少一种水溶性聚合物共价或非共价结合
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公开(公告)号：US20090081145A1
公开(公告)日：2009-03-26
申请号：US12158875
申请日：2006-12-23
IPC分类号： A61K8/49 , C07K14/47 , C07K7/00 , C07K1/08 , C07D239/48 , C07D487/04 , C07D239/54 , C07D475/00 , A61Q5/00
CPC分类号： A61Q5/04 , A61K8/49 , A61K8/4926 , A61K8/4953 , C07K14/505
摘要： The present invention relates to an improved method of formation of disulfide bridges in substances bearing SH groups, in particular peptides, for example by formation of intramolecular disulfide bridges, in which a heterocyclic compound having at least one nitrogen atom (e.g. caffeine or a caffeine-like substance) is used for catalysis of the reaction. It was found, surprisingly, that addition of the heterocyclic substance increases both the yield and the purity of the product bearing disulfide bridges.
摘要翻译： 本发明涉及一种在含有SH基团的物质（特别是肽）中形成二硫键的改进方法，例如通过形成分子内二硫键，其中具有至少一个氮原子的杂环化合物（例如咖啡因或咖啡因 - 类物质）用于催化反应。 发现令人惊讶的是，添加杂环物质增加了带有二硫键的产物的产率和纯度。
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