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公开(公告)号:US20070027177A1
公开(公告)日:2007-02-01
申请号:US10571870
申请日:2004-09-17
申请人: B. Trotter , Christopher Claiborne , Gerald Ponticello , Charles McIntyre , Nigel Liverton , David Claremon
发明人: B. Trotter , Christopher Claiborne , Gerald Ponticello , Charles McIntyre , Nigel Liverton , David Claremon
IPC分类号: A61K31/4741 , A61K31/4704 , C07D217/22
CPC分类号: C07D217/24 , C07D455/04 , C07D471/04
摘要: The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译: 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构(I)的化合物等。
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公开(公告)号:US20070054892A1
公开(公告)日:2007-03-08
申请号:US10572236
申请日:2004-09-22
申请人: Richard Isaacs , Christopher Dinsmore , B. Trotter , Nigel Liverton , Douglas Beshore , Nathan Kett , Charles McIntyre , Kausik Nanda , David Claremon
发明人: Richard Isaacs , Christopher Dinsmore , B. Trotter , Nigel Liverton , Douglas Beshore , Nathan Kett , Charles McIntyre , Kausik Nanda , David Claremon
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/4709 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号: C04B35/632 , C07D217/22 , C07D217/26 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/04
摘要: The present invention relates to compounds of structural formula I: I useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译: 本发明涉及结构式I的化合物:可用作治疗心律失常的钾通道抑制剂等。
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公开(公告)号:US20060276450A1
公开(公告)日:2006-12-07
申请号:US10572342
申请日:2004-09-17
申请人: B. Trotter , Kausik Nanda , Nathan Kett , Christopher Dinsmore , Gerald Ponticello , David Claremon
发明人: B. Trotter , Kausik Nanda , Nathan Kett , Christopher Dinsmore , Gerald Ponticello , David Claremon
IPC分类号: A61K31/4709 , C07D491/04 , C07D405/02 , C07D403/02 , C07D401/02
CPC分类号: C07D217/14 , C07D217/16 , C07D401/04
摘要: The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译: 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构(I)的化合物等。
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公开(公告)号:US20070173525A1
公开(公告)日:2007-07-26
申请号:US11731908
申请日:2007-04-02
申请人: Annette Kim , Craig Stump , Christopher Dinsmore , Samuel Graham , Theresa Williams , Diem Nguyen , B. Trotter
发明人: Annette Kim , Craig Stump , Christopher Dinsmore , Samuel Graham , Theresa Williams , Diem Nguyen , B. Trotter
IPC分类号: C07D221/22 , A61K31/473
CPC分类号: C07D471/08 , A01M31/06
摘要: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
摘要翻译: 本发明涉及能够抑制,调节和/或调节受体型和非受体型酪氨酸激酶的信号转导的化合物。 本发明的化合物具有包含苯并吖嗪部分的核心结构。 本发明还涉及这些化合物的药学上可接受的盐,水合物和立体异构体。
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公开(公告)号:US20060030595A1
公开(公告)日:2006-02-09
申请号:US11188466
申请日:2005-07-25
申请人: Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
发明人: Mark Bilodeau , Christopher Dinsmore , Jeffrey Bergman , B. Trotter , Lou Neilson , Zhicai Wu , Peter Manley , John Hartnett
IPC分类号: A61K31/506 , A61K31/444 , C07D401/14 , C07D403/14
CPC分类号: C07D213/57 , C07D213/06 , C07D213/30 , C07D213/42 , C07D213/61 , C07D213/64 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/81 , C07D213/84 , C07D401/14 , C07D413/14 , C07D417/14
摘要: The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
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公开(公告)号:US20070054894A1
公开(公告)日:2007-03-08
申请号:US10572341
申请日:2004-09-17
申请人: B. Trotter , Richard Isaacs
发明人: B. Trotter , Richard Isaacs
IPC分类号: A61K31/55 , A61K31/517 , A61K31/519 , C07D487/04
CPC分类号: C07D471/04 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D487/04
摘要: The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
摘要翻译: 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构(I)的化合物等。
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公开(公告)号:US20050227988A1
公开(公告)日:2005-10-13
申请号:US10510610
申请日:2003-04-08
申请人: B. Trotter
发明人: B. Trotter
IPC分类号: A61K31/138 , A61K31/337 , A61K31/4465 , A61K31/4535 , A61K31/498 , A61K31/4995 , A61K39/395 , A61K45/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P15/00 , A61P17/06 , A61P19/02 , A61P19/04 , A61P25/00 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07D487/04 , C07D487/08
CPC分类号: C07D487/08
摘要: The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
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