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公开(公告)号：US20070173525A1
公开(公告)日：2007-07-26
申请号：US11731908
申请日：2007-04-02
申请人： Annette Kim , Craig Stump , Christopher Dinsmore , Samuel Graham , Theresa Williams , Diem Nguyen , B. Trotter
发明人： Annette Kim , Craig Stump , Christopher Dinsmore , Samuel Graham , Theresa Williams , Diem Nguyen , B. Trotter
IPC分类号： C07D221/22 , A61K31/473
CPC分类号： C07D471/08 , A01M31/06
摘要： The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
摘要翻译： 本发明涉及能够抑制，调节和/或调节受体型和非受体型酪氨酸激酶的信号转导的化合物。 本发明的化合物具有包含苯并吖嗪部分的核心结构。 本发明还涉及这些化合物的药学上可接受的盐，水合物和立体异构体。
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公开(公告)号：US20050239815A1
公开(公告)日：2005-10-27
申请号：US10510611
申请日：2003-04-08
申请人： Annette Kim , Craig Stump , Christopher Dinsmore , Samuel Graham , Theresa Williams , Diem Nguyen , B. Wesley Trotter
发明人： Annette Kim , Craig Stump , Christopher Dinsmore , Samuel Graham , Theresa Williams , Diem Nguyen , B. Wesley Trotter
IPC分类号： A01M31/06 , A61K31/138 , A61K31/337 , A61K31/439 , A61K31/4465 , A61K31/4525 , A61K31/4709 , A61K31/473 , A61K31/5377 , A61K39/00 , A61P1/00 , A61P3/10 , A61P35/00 , A61P37/06 , A61P43/00 , C07D471/06 , C07D471/08
CPC分类号： C07D471/08 , A01M31/06
摘要： The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a benzazocine moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
摘要翻译： 本发明涉及能够抑制，调节和/或调节受体型和非受体型酪氨酸激酶的信号转导的化合物。 本发明的化合物具有包含苯并吖嗪部分的核心结构。 本发明还涉及这些化合物的药学上可接受的盐，水合物和立体异构体。
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公开(公告)号：US20060189600A1
公开(公告)日：2006-08-24
申请号：US10547228
申请日：2004-03-10
申请人： Ian Bell , Samuel Graham , Theresa Williams , Craig Stump
发明人： Ian Bell , Samuel Graham , Theresa Williams , Craig Stump
IPC分类号： A61K31/5513 , C07D403/02
CPC分类号： C07D403/12 , C07D235/02
摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20070293470A1
公开(公告)日：2007-12-20
申请号：US11660798
申请日：2005-09-09
申请人： Theresa Williams , Christopher Burgey , Thomas Tucker , Craig Stump , Ian Bell
发明人： Theresa Williams , Christopher Burgey , Thomas Tucker , Craig Stump , Ian Bell
IPC分类号： A61K31/55 , A61K31/40 , A61P25/06 , C07D211/00 , C07D223/02 , C07D267/02 , C07D223/00 , C07D209/54 , A61K31/44
CPC分类号： C07D471/04 , C07D401/12 , C07D413/12 , C07D519/00
摘要： The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I的化合物：I（其中变量A 1，A 2，B，J，K，m，n，R 4 R 5c，R 5b和R 5c如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗 或预防CGRP所涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20070287696A1
公开(公告)日：2007-12-13
申请号：US10587121
申请日：2005-01-25
IPC分类号： A61K31/551 , A61K31/454 , A61K31/553 , A61K31/554 , A61P25/00 , A61P25/06 , C07D243/08 , C07D267/10 , C07D401/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, D, G, J, Q, T, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, pharmaceutical compositions comprising these compounds, use of these compounds and compositions to prevent or treat diseases involving CGRP.
摘要翻译： 式I化合物和式II化合物（其中R 1，R 2，R 3，R 4，R 4， >，A，B，D，G，J，Q，T，W，X和Y如本文所定义）可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，药物组合物 包括这些化合物，使用这些化合物和组合物来预防或治疗涉及CGRP的疾病。
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公开(公告)号：US20060148790A1
公开(公告)日：2006-07-06
申请号：US10562298
申请日：2004-06-24
IPC分类号： A61K31/5513 , C07D403/14
CPC分类号： C07D401/14
摘要： The present invention is directed to compounds of Formula I: (where variables R1, R2, R3, R6, R7, G, J, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物：其中R 1，R 2，R 3，R 6， G，J，W，X和Y如本文所定义），其可用作CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病， 如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20110021516A1
公开(公告)日：2011-01-27
申请号：US12934208
申请日：2009-03-24
申请人： Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
发明人： Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
IPC分类号： A61K31/5365 , C07D471/04 , A61K31/496 , A61P25/06
CPC分类号： C07D471/10 , C07D403/06 , C07D471/20 , C07D519/00
摘要： The present invention is directed to compounds of the formula (I): (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, G1, G2, G3, G4, J, Q, Ea, Eb, Ec, R6, R7, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式（I）的化合物：（其中变量A1，A2，A3，A4，A5，A6，A7，A8，G1，G2，G3，G4，J，Q，Ea，Eb，Ec ，R6，R7，RPG和Y如本文所述），其是CGRP受体的拮抗剂，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20080004304A1
公开(公告)日：2008-01-03
申请号：US11662424
申请日：2005-09-06
申请人： Ian Bell , Craig Stump , Cory Theberge
发明人： Ian Bell , Craig Stump , Cory Theberge
IPC分类号： A61K31/40 , A61K31/437 , A61P25/06 , C07D209/54 , C07D487/04
CPC分类号： C07D209/96 , C07D471/04 , C07D487/04
摘要： The present invention is directed to compounds of Formula (I): where variables A1, A2, B, J, K, m, n, R4, R5a, R5a, R5c and X are as defined herein useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式（I）的化合物：其中变量A 1，A 2，B，J，K，m，n，R 4 R 5a，R 5a，R 5c和X如本文所定义，可用作CGRP受体的拮抗剂，并且可用于 治疗或预防CGRP涉及的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US08765759B2
公开(公告)日：2014-07-01
申请号：US12934208
申请日：2009-03-24
申请人： Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
发明人： Harold G. Selnick , Ian M. Bell , Melody McWherter , Donnette D. Staas , Shawn J. Stachel , Thomas Steele , Craig Stump , Michael R. Wood , C. Blair Zartman
IPC分类号： A61K31/437 , A61K31/497 , A61K31/4985
CPC分类号： C07D471/10 , C07D403/06 , C07D471/20 , C07D519/00
摘要： The present invention is directed to compounds of the formula: (wherein variables A1, A2, A3, G1, G2, G3, G4, J, Ea, Eb, Ec, R6, R7, and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及下式的化合物：其中作为拮抗剂的式（其中变量A1，A2，A3，G1，G2，G3，G4，J，Ea，Eb，Ec，R6，R7和Y如本文所述） 的CGRP受体，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US20070111982A1
公开(公告)日：2007-05-17
申请号：US10546889
申请日：2004-03-10
申请人： Ian Bell , Steven Gallicchio , Craig Stump , C. Zartman
发明人： Ian Bell , Steven Gallicchio , Craig Stump , C. Zartman
IPC分类号： A61K31/553 , A61K31/4747 , A61K31/4188 , C07D413/02
CPC分类号： C07D233/78 , C07D235/02 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D513/04
摘要： The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的化合物，其可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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