公开(公告)号：US20240309409A1

公开(公告)日：2024-09-19

申请号：US18435340

申请日：2024-02-07

Applicant: BASF SE

Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

IPC: C12P13/02 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00

CPC classification number: C12P13/02 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00 ,  C12Y104/03003 ,  C12Y206/01019

Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US11560577B2

公开(公告)日：2023-01-24

申请号：US16997133

申请日：2020-08-19

Applicant: BASF SE

Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

IPC: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US11913048B2

公开(公告)日：2024-02-27

申请号：US18179136

申请日：2023-03-06

Applicant: BASF SE

Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

IPC: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

CPC classification number: C12P13/02 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00 ,  C12Y104/03003 ,  C12Y206/01019 ,  A01N57/20 ,  A01N25/30 ,  A01N57/18

Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US11905538B2

公开(公告)日：2024-02-20

申请号：US17530018

申请日：2021-11-18

Applicant: BASF SE

Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

IPC: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

CPC classification number: C12P13/02 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00 ,  C12Y104/03003 ,  C12Y206/01019 ,  A01N57/20 ,  A01N25/30 ,  A01N57/18

Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US11732281B2

公开(公告)日：2023-08-22

申请号：US17464887

申请日：2021-09-02

Applicant: BASF SE

Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

IPC: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

CPC classification number: C12P13/02 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00 ,  C12Y104/03003 ,  C12Y206/01019 ,  A01N57/20 ,  A01N25/30 ,  A01N57/18

Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US20210395790A1

公开(公告)日：2021-12-23

申请号：US17464887

申请日：2021-09-02

Applicant: BASF SE

Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

IPC: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US20240301452A1

公开(公告)日：2024-09-12

申请号：US18435544

申请日：2024-02-07

Applicant: BASF SE

Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

IPC: C12P13/02 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00

CPC classification number: C12P13/02 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10 ,  C12P9/00 ,  C12P13/04 ,  C12P41/00 ,  C12Y104/03003 ,  C12Y206/01019

Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US20230265472A1

公开(公告)日：2023-08-24

申请号：US18179136

申请日：2023-03-06

Applicant: BASF SE

Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

IPC: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

CPC classification number: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12Y104/03003 ,  C12Y206/01019 ,  C12N1/20 ,  C12N9/10

Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

公开(公告)号：US20220064680A1

公开(公告)日：2022-03-03

申请号：US17530018

申请日：2021-11-18

Applicant: BASF SE

Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

IPC: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2 -amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.