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    Methods for making L-glufosinate
    2.
    发明授权
    Methods for making L-glufosinate 有权

    公开(公告)号：US11560577B2

    公开(公告)日：2023-01-24

    申请号：US16997133

    申请日：2020-08-19

    Applicant: BASF SE

    Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

    IPC: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

    METHODS FOR THE PURIFICATION OF L-GLUFOSINATE
    4.
    发明公开
    METHODS FOR THE PURIFICATION OF L-GLUFOSINATE 审中-公开

    公开(公告)号：US20240247013A1

    公开(公告)日：2024-07-25

    申请号：US18628116

    申请日：2024-04-05

    Applicant: BASF SE

    Inventor： Stephen Craig Fields ,  Matthew Richard Oberholzer ,  Brian Michael Green ,  Samir Kulkarni ,  Jennifer Nelson ,  Patricia Andres

    IPC: C07F9/535 ,  C07F9/30

    CPC classification number: C07F9/535 ,  C07F9/301

    Abstract: Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.

    METHODS FOR THE PURIFICATION OF L-GLUFOSINATE
    6.
    发明公开
    METHODS FOR THE PURIFICATION OF L-GLUFOSINATE 审中-公开

    公开(公告)号：US20230219984A1

    公开(公告)日：2023-07-13

    申请号：US18180681

    申请日：2023-03-08

    Applicant: BASF SE

    Inventor： Stephen Craig Fields ,  Matthew Richard Oberholzer ,  Brian Michael Green ,  Samir Kulkarni ,  Jennifer Nelson ,  Patricia Andres

    IPC: C07F9/535 ,  C07F9/30

    CPC classification number: C07F9/535 ,  C07F9/301

    Abstract: Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.

    METHODS FOR THE PURIFICATION OF L-GLUFOSINATE
    9.
    发明公开
    METHODS FOR THE PURIFICATION OF L-GLUFOSINATE 审中-公开

    公开(公告)号：US20230219985A1

    公开(公告)日：2023-07-13

    申请号：US18180724

    申请日：2023-03-08

    Applicant: BASF SE

    Inventor： Stephen Craig Fields ,  Matthew Richard Oberholzer ,  Brian Michael Green ,  Samir Kulkarni ,  Jennifer Nelson ,  Patricia Andres

    IPC: C07F9/535 ,  C07F9/30

    CPC classification number: C07F9/535 ,  C07F9/301

    Abstract: Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.

    METHODS FOR MAKING L-GLUFOSINATE
    10.
    发明申请
    METHODS FOR MAKING L-GLUFOSINATE 有权

    公开(公告)号：US20220064680A1

    公开(公告)日：2022-03-03

    申请号：US17530018

    申请日：2021-11-18

    Applicant: BASF SE

    Inventor： Brian Michael Green ,  Michelle Lorraine Gradley

    IPC: C12P13/02 ,  C12P41/00 ,  C12P9/00 ,  C12P13/04 ,  A01N25/30 ,  A01N57/20 ,  C12N1/20 ,  C12N9/10

    Abstract: Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2 -amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deamination of D-glufosinate to PPO (2-oxo-4-(hydroxy(methyl)phosphinoyl)butyric acid). The second step involves the specific amination of PPO to L-glufosinate, using an amine group from one or more amine donors. By combining these two reactions, the proportion of L-glufosinate in a mixture of L-glufosinate and D-glufosinate can be substantially increased.

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