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公开(公告)号：US20180112242A1
公开(公告)日：2018-04-26
申请号：US15559323
申请日：2016-03-15
Applicant: BASF SE
Inventor： Jennifer JAITZIG , Mukesh KUMAR , Shakir RATANI , Matthew BLANKSCHIEN , Qingzhao WANG
IPC: C12P13/06 , C12N15/52 , C12P7/46 , C12P7/56 , C07K14/245 , C12N9/88 , C12N9/10 , C12N9/02 , C12N9/04
Abstract: The present invention relates to a recombinant microorganism, to a method for producing alanine and to the use of the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：US20210032667A1
公开(公告)日：2021-02-04
申请号：US17066007
申请日：2020-10-08
Applicant: BASF SE
Inventor： Jennifer JAITZIG , Mukesh KUMAR , Matthew David BLANKSCHIEN , Shakir RATANI , Qingzhao WANG
Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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公开(公告)号：US20230042456A1
公开(公告)日：2023-02-09
申请号：US17786864
申请日：2020-12-16
Applicant: BASF SE
Inventor： Hartwig SCHROEDER , Anne-Catrin HAILER , Birgit HOFF , Oskar ZELDER , Peter OEDMAN , Georg Benjamin WANDREY , Christian DIETZSCH , Mukesh KUMAR , Dominik SATORY , Matthew David BLANKSCHIEN , Jens Klaus PLASSMEIER
Abstract: Increasing space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility in the production of fine chemicals The inventors of the current invention have found a surprising positive effect of increased cAMP levels and/or manipulating the PTS system on the space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility of fine chemical production of a host organism. This was achieved by de-regulating adenylate cyclase cyaa by deleting the C-terminal regulatory region leading to increased cAMP levels or deleting the Crr protein activity (carbohydrate repression resistance) which regulates the carbohydrate utilization system. Both lead to increased 2-fucosyllactoe and 6-sialyllactose production (human milk oligosaccharides) and increase carbohydrate usage.
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公开(公告)号：US20200032304A1
公开(公告)日：2020-01-30
申请号：US15735875
申请日：2016-06-09
Applicant: BASF SE
Inventor： Jennifer JAITZIG , Mukesh KUMAR , Matthew BLANKSCHIEN , Shakir RATANI , Qingzhao WANG
Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant micro-organism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
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