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公开(公告)号：US3911010A
公开(公告)日：1975-10-07
申请号：US39869273
申请日：1973-09-19
申请人： BAYER AG
IPC分类号： C07C259/14 , C07D209/42 , C07C123/00
CPC分类号： C07C259/14 , C07D209/42
摘要： The present invention relates to new aminophenylamidines, to processes for their production, and to their pharmaceutical use. These new compounds are useful as paraciticides, especially as anthelmintics. Some acylaminophenylformamidines, such as N-(p-acetamidophenyl)N'',N''-dimethylformamidine (U.S. Pat. No. 3,184,482) and N-phenylacetamidines, such as N-(p-chlorophenyl)-N'',N''dimethylacetamidine, are already known. These compounds are however inactive against the helminths mentioned below.
摘要翻译： 本发明涉及新的氨基苯基脒，其制备方法及其药物用途。 这些新化合物可用作杀螨剂，特别是作为驱肠虫剂。
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公开(公告)号：US3591662A
公开(公告)日：1971-07-06
申请号：US3591662D
申请日：1966-05-26
申请人： BAYER AG
发明人： LORENZ WALTER , FEST CHRISTA , HAMMANN INGEBORG , FEDERMANN MANFRED , FLUCKE WINFRIED , STENDEL WILHELM
CPC分类号： C07F9/4096 , C07F9/097 , C07F9/1657 , C07F9/2445 , C07F9/588
摘要： PHOSPHOROUS-CONTAINING A-OXIMINO-ARYL ACETIC ACID NITRILE HAVING THE FORMULA:
R1-O-P(=X)(-R2)-O-N=C(-CN)-R3
IN WHICH R1 IS ALKYL AND HALOALKYL; R2 IS ALKYL ALKOXY, HALOALKOXY, ALKYL AMINO, DI-ALKYL AMINO, PHENYL, PHENOXY, CYCLOHEXYL AND CYCLOHESYLOXY; R3 IS PHEYL, NAPHTHYL, PRYIDYL AND SUBSTITUTED PHENYL WHICH IS SUBSTITUTED WITH MONO-, DI- AND TRIHALO, ALKYL, ALKOXY MERCAPTO AND/ OR NITRO; AND X IS OXYGEN AND SULFUR, WHICH POSSESS BIOCIDAL PROPERTIES, AND WHICH MAY BE PREPARED BY REACTING THE CORRESPONDING PHOSPHORUS ESTER HALIDE WITH THE APPROPRIATE A-OXIMINO ARYLACETIC ACID NITRILE IN THE FORM OF THE CORRESPONDING SALT OR IN THE PRESENCE OF AN ACIDBINDING AGENT. THE COMPOUNDS ARE PESTICIDES.-
公开(公告)号：US3925470A
公开(公告)日：1975-12-09
申请号：US51562674
申请日：1974-10-17
申请人： BAYER AG
IPC分类号： A61K31/155 , C07C123/00
CPC分类号： A61K31/155
摘要： 4-Amino substituted phenylamidine are anthelmintics. The compounds, of which N-(4-aminophenyl)-N'',N''-dimethylacetamidine is a representative embodiment, can be prepared through treatment of a 4-amino aniline with a carboxylic acidamide or thioamide, reduction of an appropriately substituted 4-aminophenyl-amidine, optionally followed by alkylation of the resultant 4-aminophenylamidine, formation of a Schiff base followed by quaternization and hydrolysis, or hydrolysis of a 4-acylaminophenylamidine.
摘要翻译： 4-氨基取代的苯脒是驱虫剂。 可以通过用羧酸酰胺或硫代酰胺处理4-氨基苯胺来制备其中N-（4-氨基苯基）-N'，N'-二甲基乙脒是其代表性实施方案的化合物，还原适当取代的4- 任选随后将所得4-氨基苯基 - 脒烷基化，形成希夫碱，然后季铵化和水解，或4-酰氨基苯基脒的水解。
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4.发明授权Derivatives of 2-(4-aminophenylimino)-thiazolidine and 4h-5,6-dihydro-1,3-thiazines 失效2-（4-氨基苯基） - 噻唑啉和4H-5,6-二氢-1,3-噻二嗪的衍生物
公开(公告)号：US3860590A
公开(公告)日：1975-01-14
申请号：US28909272
申请日：1972-09-14
申请人： BAYER AG
IPC分类号： C07D277/10 , A61K31/426 , A61K31/54 , A61P33/10 , C07C335/20 , C07D277/18 , C07D279/06 , C07D417/12 , C07D91/16 , C07D93/06
CPC分类号： C07D277/18 , C07C335/20
摘要： 2-(4-Aminophenylimino) derivatives of thiazolidine and -4H-5,6dihydro-1,3-thiazines, the corresponding amide and sulfonamide derivatives, and the salts thereof are anthelmintic agents. The compounds, of which 2-(4-aminophenylimino)-N-methylthiazolidine is a typical embodiment, are prepared through cyclization of a thiourea, optionally with subsequent hydrolysis, alkylation or acetylation.
摘要翻译： 噻唑烷和-4H-5,6-二氢-1,3-噻嗪的2-（4-氨基苯基亚氨基）衍生物，相应的酰胺和磺酰胺衍生物及其盐是驱肠剂。 其中2-（4-氨基苯基亚氨基）-N-甲基噻唑烷是典型的实施方案，通过硫脲环化，任选随后的水解，烷基化或乙酰化来制备。
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公开(公告)号：US3911013A
公开(公告)日：1975-10-07
申请号：US51557674
申请日：1974-10-17
申请人： BAYER AG
IPC分类号： A61K31/155 , C07C123/00
CPC分类号： A61K31/155
摘要： 4-Amino substituted phenylamidine are anthelmintics. The compounds, of which N-(4-aminophenyl)-N'',N''-dimethylacetamidine is a representative embodiment, can be prepared through treatment of a 4-amino aniline with a carboxylic acidamide or thioamide, reduction of an appropriately substituted 4-aminophenylamidine, optionally followed by alkylation of the resultant 4-aminophenylamidine, formation of a Schiff base followed by quaternization and hydrolysis, or hydrolysis of a 4-acylaminophenylamidine.
摘要翻译： 4-氨基取代的苯脒是驱虫剂。 可以通过用羧酸酰胺或硫代酰胺处理4-氨基苯胺来制备其中N-（4-氨基苯基）-N'，N'-二甲基乙脒是其代表性实施方案的化合物，还原适当取代的4- 任选地随后将所得4-氨基苯基 - 脒烷基化，形成希夫碱，然后季铵化和水解，或4-酰氨基苯基脒的水解。
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6.发明授权
公开(公告)号：US3689648A
公开(公告)日：1972-09-05
申请号：US3689648D
申请日：1968-10-24
申请人： BAYER AG
发明人： LORENZ WALTER , FEST CHRISTA , HAMMANN INGEBORG , FEDERMANN MANFRED , FLUCKE WINFRIED , STENDEL WILHELM
CPC分类号： C07F9/1657 , C07F9/097 , C07F9/4096
摘要： Compositions and methods of using phosphoryl-, phosphonyl-, thionophosphoryl- and thionophosphonyl- - Alpha -oximinoarylacetic acid nitriles which possess pesticidal, especially insecticidal and/or acaricidal, properties, and which may be produced by reacting the corresponding phosphorus acid ester halide with the corresponding Alpha -oximino-arylacetic acid nitrile.
摘要翻译： 使用具有杀虫，特别是杀虫和/或杀螨的性质的磷酰基，膦酰基，硫代磷酰基和硫代膦酰基-α-肟基 - 芳基乙酸腈的组合物和方法，其可以通过使相应的磷酸酯卤化物 与相应的α-肟基 - 芳基乙酸腈。
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公开(公告)号：US3478037A
公开(公告)日：1969-11-11
申请号：US3478037D
申请日：1968-03-07
申请人： BAYER AG
IPC分类号： A01N57/24 , A61K31/675 , C07F9/58 , C07D31/50 , A01N9/22
摘要： Phosphonic and thiphosphonic acid esters of 2-hydroxy 3,5,6-trichloropyridine, R1 = alkyl-R2 = alkyl-, phenyl-X = O or S Insecticides, acaricides. Potassium carbonate is added to a suspension of 2-hydroxy 3,5,6-trichloropyridine in acetonitrile and the mixture warmed to 60 deg. C for 1/2 hour. When the temperature has cooled to 50 deg. C methylthiono-phosphonic O-ethyl chloride is added dropwise. The mixture is heated for 4 hrs. at 70 deg. C and the stirring is continued for another 3 hrs. After filtration of the separated sodium chloride the filtrate is extracted with benzene. The benzene solution is washed with water, dried and the solvent distilled off. Recrystallisation of the residue from ethanol yields O-ethyl O-(3,5,6-trichloropyridyl-2) methylthiono-phosphonate.
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公开(公告)号：US3925471A
公开(公告)日：1975-12-09
申请号：US51562774
申请日：1974-10-17
申请人： BAYER AG
IPC分类号： A61K31/155 , C07C123/00
CPC分类号： A61K31/155
摘要： 4-Amino substituted phenylamidine are anthelmintics. The compounds, of which N-(4-aminophenyl)-N'',N''-dimethylacetamidine is a representative embodiment, can be prepared through treatment of a 4-amino aniline with a carboxylic acidamide or thioamide, reduction of an appropriately substituted 4-aminophenylamidine, optionally followed by alkylation of the resultant 4-aminophenylamidine, formation of a Schiff base followed by quaternization and hydrolysis, or hydrolysis of a 4-acylaminophenylamidine.
摘要翻译： 4-氨基取代的苯脒是驱虫剂。 可以通过用羧酸酰胺或硫代酰胺处理4-氨基苯胺来制备其中N-（4-氨基苯基）-N'，N'-二甲基乙脒是其代表性实施方案的化合物，还原适当取代的4- 任选地随后将所得4-氨基苯基 - 脒烷基化，形成希夫碱，然后季铵化和水解，或4-酰氨基苯基脒的水解。
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公开(公告)号：US3923888A
公开(公告)日：1975-12-02
申请号：US39981373
申请日：1973-09-24
申请人： BAYER AG
IPC分类号： A61K31/155 , C07C123/00
CPC分类号： A61K31/155
摘要： The present invention relates to new aminophenylamidines and cycloamidines and salts thereof, to processes for their production, and to their use as medicines, especially as parasiticides. Acylaminophenylformamidines, such as N-(p-acetamidophenyl)-N'', N''-dimethylformamidine (U.S. Pat. No. 3,184,482) are already known. This compound, as well as other formamidine derivatives, are, however, ineffective against helminths. Furthermore, Nphenylacetamidines, such as N-(p-chlorophenyl)-N'',N''dimethylacetamidine, are known. These compounds are also ineffective against helminths.
摘要翻译： 本发明涉及新的氨基苯基脒和环脒及其盐，其生产方法及其用作药物，特别是作为杀寄生物剂。
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公开(公告)号：US3919315A
公开(公告)日：1975-11-11
申请号：US42225873
申请日：1973-12-06
申请人： BAYER AG
IPC分类号： A61K31/155 , C07C123/00
CPC分类号： A61K31/155
摘要： 4-Amino substituted phenylamidine are anthelmintics. The compounds, of which N-(4-aminophenyl)N'',N''-dimethylacetamidine is a representative embodiment, can be prepared through treatment of a 4-amino aniline with a carboxylic acidamide or thioamide, reduction of an appropriately substituted 4-amino-phenylamidine, optionally followed by alkylation of the resultant 4aminophenylamidine, formation of a Schiff base followed by quaternization and hydrolysis, or hydrolysis of a 4acylaminophenylamidine.
摘要翻译： 4-氨基取代的苯脒是驱虫剂。 其中N-（4-氨基苯基）N'，N'-二甲基乙脒是其代表性实施方案的化合物可以通过用羧酸酰胺或硫代酰胺处理4-氨基苯胺来制备，还原适当取代的4-氨基 - 任选地随后将所得4-氨基苯基脒烷基化，形成希夫碱，然后季铵化和水解，或4-酰氨基苯基脒的水解。
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