公开(公告)号：US3609166A

公开(公告)日：1971-09-28

申请号：US3609166D

申请日：1968-08-19

Applicant: BAYER AG

Inventor： GAUSS WALTER ,  HERLINGER HEINZ ,  THOMAS HERBERT ,  PLEMPEL MANFRED

IPC: C07D521/00 ,  C08G69/42 ,  C08G73/06 ,  C09J5/06 ,  C07D49/38

CPC classification number: C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C08G69/42 ,  C08G73/0655 ,  C09J5/06

Abstract: Carbamic acid esters are provided which, inter alia, have anthelmintic action against nematodes and fungicidal activity against Aspegillus niger, fumigatus and nidulans, Trichophyton species and Candida albicans at concentrations as low as 4 gamma /ml. The esters have the formula:

Y is hydrogen or alkyl, A and B are the same or different and are each hydrogen, halogen, nitro, lower alkyl or lower alkoxy, M AND N ARE 1 OR 2, AND R is substituted or unsubstituted aliphatic, aralkyl, aryl or heterocyclic, and are prepared by reacting an amine of the formula:

Y is hydrogen or alkyl, A and B are the same or different and are each hydrogen, halogen, nitro, lower alkyl or lower alkoxy, and M AND N ARE 1 OR 2, WITH A CARBONIC ACID DERIVATIVE OF THE FORMULA: IN WHICH R is unsubstituted or substituted aliphatic, aralkyl, aryl, or a heterocyclic radical, and D is halogen, OR1 or WHEREIN R1 and R2 are the same or different and have any of the above meanings of R, or R and D further being the residual constituents of the ring system of glycol carbonate and benzocatechol carbonate.

公开(公告)号：US3860590A

公开(公告)日：1975-01-14

申请号：US28909272

申请日：1972-09-14

Applicant: BAYER AG

Inventor： WOLLWEBER HARTMUND ,  FLUCKE WINFRIED ,  SCHULZ HANS PETER ,  THOMAS HERBERT

IPC: C07D277/10 ,  A61K31/426 ,  A61K31/54 ,  A61P33/10 ,  C07C335/20 ,  C07D277/18 ,  C07D279/06 ,  C07D417/12 ,  C07D91/16 ,  C07D93/06

CPC classification number: C07D277/18 ,  C07C335/20

Abstract: 2-(4-Aminophenylimino) derivatives of thiazolidine and -4H-5,6dihydro-1,3-thiazines, the corresponding amide and sulfonamide derivatives, and the salts thereof are anthelmintic agents. The compounds, of which 2-(4-aminophenylimino)-N-methylthiazolidine is a typical embodiment, are prepared through cyclization of a thiourea, optionally with subsequent hydrolysis, alkylation or acetylation.

Abstract translation: 噻唑烷和-4H-5,6-二氢-1,3-噻嗪的2-（4-氨基苯基亚氨基）衍生物，相应的酰胺和磺酰胺衍生物及其盐是驱肠剂。 其中2-（4-氨基苯基亚氨基）-N-甲基噻唑烷是典型的实施方案，通过硫脲环化，任选随后的水解，烷基化或乙酰化来制备。