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公开(公告)号：US11377417B2
公开(公告)日：2022-07-05
申请号：US16904786
申请日：2020-06-18
发明人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
IPC分类号： C07C231/14 , A61K45/06 , C07C235/38 , C07C233/55 , A61K31/196 , A61K9/00
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US10259776B2
公开(公告)日：2019-04-16
申请号：US16001146
申请日：2018-06-06
发明人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker-Pelster , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
IPC分类号： C07C231/14 , A61K9/00 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US09498480B2
公开(公告)日：2016-11-22
申请号：US14382746
申请日：2013-03-05
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexandros Vakalopoulos , Dieter Lang , Frank Wunder , Walter Hübsch , Michael Hahn
IPC分类号： A61K31/519 , C07D487/04 , A61K31/522 , A61K45/06 , C07D519/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的氮杂双环，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物的用途 特别用于治疗和/或预防心血管疾病。
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公开(公告)号：US10023528B2
公开(公告)日：2018-07-17
申请号：US15158331
申请日：2016-05-18
发明人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker-Pelster , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
IPC分类号： C07C231/14 , A61K9/00 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US09018414B2
公开(公告)日：2015-04-28
申请号：US14045630
申请日：2013-10-03
发明人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker-Pelster , Friederike Stoll , Andreas Knorr
IPC分类号： C07C205/00 , C07C229/00 , C07C233/88 , C07C233/45 , C07C205/38 , C07C233/55 , C07C255/60 , C07D305/06 , A61K31/196 , A61K31/655 , C07C231/02
CPC分类号： C07C233/88 , A61K31/196 , A61K31/655 , C07C205/38 , C07C231/02 , C07C233/45 , C07C233/55 , C07C255/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D305/06
摘要： The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的3-苯基丙酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 治疗和/或预防心血管疾病。
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公开(公告)号：US20150025090A1
公开(公告)日：2015-01-22
申请号：US14382746
申请日：2013-03-05
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexandros Vakalopoulos , Dieter Lang , Frank Wunder , Walter Hübsch , Michael Hahn
IPC分类号： A61K31/519 , A61K45/06 , A61K31/522 , C07D519/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的氮杂双环，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物的用途 特别用于治疗和/或预防心血管疾病。
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