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公开(公告)号：US20150025090A1
公开(公告)日：2015-01-22
申请号：US14382746
申请日：2013-03-05
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexandros Vakalopoulos , Dieter Lang , Frank Wunder , Walter Hübsch , Michael Hahn
IPC分类号： A61K31/519 , A61K45/06 , A61K31/522 , C07D519/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的氮杂双环，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物的用途 特别用于治疗和/或预防心血管疾病。
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公开(公告)号：US09505786B2
公开(公告)日：2016-11-29
申请号：US14738148
申请日：2015-06-12
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： C07D471/04 , A61K31/53 , A61P9/10 , A61P9/12 , A61P7/02 , C07D519/00 , A61K31/519 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US09205077B2
公开(公告)日：2015-12-08
申请号：US14304801
申请日：2014-06-13
发明人： Walter Hübsch , Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Peter Nell , Katja Zimmermann , Frank Süβmeier , Joerg Keldenich
IPC分类号： C07D413/12 , A61K31/44 , C07D213/70 , C07D417/12 , C07D417/14 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/85 , C07D401/12
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的2-烷氧基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病。
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公开(公告)号：US09095582B2
公开(公告)日：2015-08-04
申请号：US13893344
申请日：2013-05-14
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Jorg Keldenich , Alexandros Vakalopoulos , Frank Süssmeier , Katja Zimmermann , Dieter Lang , Daniel Meibom
IPC分类号： C07D413/14 , A61K31/443 , A61K31/4439 , C07D413/12 , C07D419/14 , A61K31/695 , A61K45/06 , C07F7/10
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
摘要翻译： 本申请涉及新型取代的芳氧唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管和代谢紊乱。
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公开(公告)号：US09498480B2
公开(公告)日：2016-11-22
申请号：US14382746
申请日：2013-03-05
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexandros Vakalopoulos , Dieter Lang , Frank Wunder , Walter Hübsch , Michael Hahn
IPC分类号： A61K31/519 , C07D487/04 , A61K31/522 , A61K45/06 , C07D519/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的氮杂双环，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物的用途 特别用于治疗和/或预防心血管疾病。
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6.发明授权公开(公告)号：US08772498B2
公开(公告)日：2014-07-08
申请号：US13801484
申请日：2013-03-13
发明人： Alexandros Vakalopoulos , Daniel Meibom , Barbara Albrecht-Küpper , Katja Zimmermann , Jörg Keldenich , Hans-Georg Lerchen , Peter Nell , Frank Süβmeier , Ursula Krenz
IPC分类号： A61K31/44 , C07D409/00
CPC分类号： C07D417/14 , A61K47/64 , C07D417/12 , C07K5/0202 , C07K5/06026 , C07K5/06034 , C07K5/06086 , C07K5/06147 , C07K5/06165
摘要： The present application relates to novel 6-alkylamino-substituted dicyanopyridines, to their amino acid ester prodrugs, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的6-烷基氨基取代的二氰基吡啶，其氨基酸酯前药，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/ 或预防疾病，优选用于治疗和/或预防心血管疾病。
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公开(公告)号：US09023849B2
公开(公告)日：2015-05-05
申请号：US13736692
申请日：2013-01-08
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Holger Paulsen , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： A61K31/5365 , C07D253/00 , C07D487/04 , C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present application relates to novel substituted fused imidazoles and pyrazoles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof producing medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的取代的稠合咪唑和吡唑，其制备方法，单独或组合用于治疗和/或预防疾病及其用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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