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公开(公告)号：US10259776B2
公开(公告)日：2019-04-16
申请号：US16001146
申请日：2018-06-06
发明人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker-Pelster , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
IPC分类号： C07C231/14 , A61K9/00 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US09505786B2
公开(公告)日：2016-11-29
申请号：US14738148
申请日：2015-06-12
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： C07D471/04 , A61K31/53 , A61P9/10 , A61P9/12 , A61P7/02 , C07D519/00 , A61K31/519 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US09023849B2
公开(公告)日：2015-05-05
申请号：US13736692
申请日：2013-01-08
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Holger Paulsen , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： A61K31/5365 , C07D253/00 , C07D487/04 , C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present application relates to novel substituted fused imidazoles and pyrazoles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof producing medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的取代的稠合咪唑和吡唑，其制备方法，单独或组合用于治疗和/或预防疾病及其用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US11377417B2
公开(公告)日：2022-07-05
申请号：US16904786
申请日：2020-06-18
发明人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva Maria Becker-Pelster , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
IPC分类号： C07C231/14 , A61K45/06 , C07C235/38 , C07C233/55 , A61K31/196 , A61K9/00
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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5.发明授权Substituted triazine derivatives and use thereof as stimulators of soluble guanylate cyclase 有权取代的三嗪衍生物和其可用作可溶性鸟苷酸环化酶的刺激剂公开(公告)号：US09133191B2
公开(公告)日：2015-09-15
申请号：US14371054
申请日：2013-01-08
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Frank Wunder , Dieter Lang
IPC分类号： C07D471/04 , A61K31/53 , A61K45/06
CPC分类号： C07D471/04 , A61K31/53 , A61K45/06
摘要： The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶，其制备方法，其单独使用或组合用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US10023528B2
公开(公告)日：2018-07-17
申请号：US15158331
申请日：2016-05-18
发明人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker-Pelster , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
IPC分类号： C07C231/14 , A61K9/00 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US09266885B2
公开(公告)日：2016-02-23
申请号：US14552122
申请日：2014-11-24
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Walter Kroh , Andreas Knorr , Eva-Maria Becker , Frank Wunder , Volkhart Min-Jian Li , Elke Hartmann , Joachim Mittendorf , Karl-Heinz Schlemmer , Rolf Jautelat , Donald Bierer
IPC分类号： C07D471/04 , A61K45/06 , A61K31/506
CPC分类号： A61K31/506 , A61K45/06 , C07C57/145 , C07C309/04 , C07C309/05 , C07D471/04
摘要： The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US09018414B2
公开(公告)日：2015-04-28
申请号：US14045630
申请日：2013-10-03
发明人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker-Pelster , Friederike Stoll , Andreas Knorr
IPC分类号： C07C205/00 , C07C229/00 , C07C233/88 , C07C233/45 , C07C205/38 , C07C233/55 , C07C255/60 , C07D305/06 , A61K31/196 , A61K31/655 , C07C231/02
CPC分类号： C07C233/88 , A61K31/196 , A61K31/655 , C07C205/38 , C07C231/02 , C07C233/45 , C07C233/55 , C07C255/60 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D305/06
摘要： The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的3-苯基丙酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是 治疗和/或预防心血管疾病。
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9.发明申请SUBSTITUTED TRIAZINE DERIVATIVES AND USE THEREOF AS STIMULATORS OF SOLUBLE GUANYLATE CYCLASE 有权取代的TRIAZINE衍生物及其作为可溶性葡萄糖循环的刺激物的用途公开(公告)号：US20150094308A1
公开(公告)日：2015-04-02
申请号：US14371054
申请日：2013-01-08
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Frank Wunder , Dieter Lang
IPC分类号： C07D471/04 , A61K45/06 , A61K31/53
CPC分类号： C07D471/04 , A61K31/53 , A61K45/06
摘要： The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶，其制备方法，其单独使用或组合用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途， 特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20150025090A1
公开(公告)日：2015-01-22
申请号：US14382746
申请日：2013-03-05
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexandros Vakalopoulos , Dieter Lang , Frank Wunder , Walter Hübsch , Michael Hahn
IPC分类号： A61K31/519 , A61K45/06 , A61K31/522 , C07D519/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的氮杂双环，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物的用途 特别用于治疗和/或预防心血管疾病。
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