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公开(公告)号：US09023849B2
公开(公告)日：2015-05-05
申请号：US13736692
申请日：2013-01-08
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Holger Paulsen , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： A61K31/5365 , C07D253/00 , C07D487/04 , C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06
CPC分类号： C07D487/04 , A61K31/519 , A61K31/53 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： The present application relates to novel substituted fused imidazoles and pyrazoles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof producing medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的取代的稠合咪唑和吡唑，其制备方法，单独或组合用于治疗和/或预防疾病及其用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20150025090A1
公开(公告)日：2015-01-22
申请号：US14382746
申请日：2013-03-05
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Alexandros Vakalopoulos , Dieter Lang , Frank Wunder , Walter Hübsch , Michael Hahn
IPC分类号： A61K31/519 , A61K45/06 , A61K31/522 , C07D519/00
CPC分类号： A61K31/519 , A61K31/522 , A61K45/06 , C07D487/04 , C07D519/00
摘要： The present application relates to novel substituted azabicycles, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的氮杂双环，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于制备用于治疗和/或预防疾病的药物的用途 特别用于治疗和/或预防心血管疾病。
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公开(公告)号：US09505786B2
公开(公告)日：2016-11-29
申请号：US14738148
申请日：2015-06-12
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： C07D471/04 , A61K31/53 , A61P9/10 , A61P9/12 , A61P7/02 , C07D519/00 , A61K31/519 , A61K45/06
CPC分类号： C07D519/00 , A61K31/519 , A61K31/53 , A61K45/06 , C07D471/04
摘要： The present application relates to novel substituted fused pyrimidines and triazines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的稠合嘧啶和三嗪，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产药物用于治疗和/或预防 疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US09205077B2
公开(公告)日：2015-12-08
申请号：US14304801
申请日：2014-06-13
发明人： Walter Hübsch , Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Peter Nell , Katja Zimmermann , Frank Süβmeier , Joerg Keldenich
IPC分类号： C07D413/12 , A61K31/44 , C07D213/70 , C07D417/12 , C07D417/14 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/85 , C07D401/12
CPC分类号： A61K31/44 , A61K31/4439 , A61K31/444 , A61K45/06 , C07D213/70 , C07D213/85 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的2-烷氧基取代的二氰基吡啶，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病。
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公开(公告)号：US09095582B2
公开(公告)日：2015-08-04
申请号：US13893344
申请日：2013-05-14
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Jorg Keldenich , Alexandros Vakalopoulos , Frank Süssmeier , Katja Zimmermann , Dieter Lang , Daniel Meibom
IPC分类号： C07D413/14 , A61K31/443 , A61K31/4439 , C07D413/12 , C07D419/14 , A61K31/695 , A61K45/06 , C07F7/10
CPC分类号： A61K31/4439 , A61K31/695 , A61K45/06 , C07D413/12 , C07D413/14 , C07D419/14 , C07F7/10
摘要： The present application relates to novel substituted aryloxazole derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.
摘要翻译： 本申请涉及新型取代的芳氧唑衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗和/ /或预防心血管和代谢紊乱。
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6.发明申请SUBSTITUTED BENZOTHIENYL - PYRROLOTRIAZINES AND USES THEREOF IN THE TREATMENT CANCER 有权替代苯扎林 - 吡格列酮及其在治疗癌症中的应用公开(公告)号：US20150080371A1
公开(公告)日：2015-03-19
申请号：US14365024
申请日：2012-12-11
发明人： Marie-Pierre Collin , Dirk Brohm , Melanie Heroult , Mario Lobell , Walter Hübsch , Klemens Lustig , Sylvia Grünewald , Ulf Bömer , Verena Vöhringer , Niels Lindner
IPC分类号： C07D487/04 , A61K31/541 , A61K31/553 , A61K31/551 , A61K31/53 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07D409/04 , C07D409/14
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-fJ[1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
摘要翻译： 本发明涉及具有蛋白酪氨酸激酶抑制活性的新的取代的5-（1-苯并噻吩-2-基）吡咯并[2,1-f] [1,2,4]三嗪-4-胺衍生物，其制备方法 这种化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗增殖性疾病，特别是癌症和肿瘤疾病的用途。
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公开(公告)号：US20150031676A1
公开(公告)日：2015-01-29
申请号：US14380755
申请日：2013-02-20
发明人： Mario Lobell , Walter Hübsch , Hartmut Schirok , Mélanie Héroult , Dirk Brohm , Marie-Pierre Collin , Sylvia Grünewald , Klemens Lustig , Ulf Bömer , Verena Vöhringer , Niels Lindner
IPC分类号： C07D487/04 , C07D519/00 , A61K31/5513 , A61K31/53 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5513 , C07D409/04 , C07D409/14 , C07D519/00
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
摘要翻译： 本发明涉及具有蛋白酪氨酸激酶抑制活性的新的取代的5-（1-苯并噻吩-2-基）吡咯并[2,1-f] [1,2,4]三嗪-4-胺衍生物，其制备方法 的这些化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗增殖性疾病，特别是癌症和肿瘤疾病的用途。
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公开(公告)号：US09598416B2
公开(公告)日：2017-03-21
申请号：US14365024
申请日：2012-12-11
发明人： Marie-Pierre Collin , Dirk Brohm , Mélanie Héroult , Mario Lobell , Walter Hübsch , Klemens Lustig , Sylvia Grünewald , Ulf Bömer , Verena Vöhringer , Niels Lindner
IPC分类号： C07D487/04 , C07D409/04 , C07D409/14 , A61K31/53 , A61K31/382 , A61P35/00 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K31/553 , C07D409/04 , C07D409/14
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-fJ[1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
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公开(公告)号：US09475815B2
公开(公告)日：2016-10-25
申请号：US14380755
申请日：2013-02-20
发明人： Mario Lobell , Walter Hübsch , Hartmut Schirok , Mélanie Héroult , Dirk Brohm , Marie-Pierre Collin , Sylvia Grünewald , Klemens Lustig , Ulf Bömer , Verena Voehringer , Niels Lindner
IPC分类号： C07D487/04 , C07D409/04 , C07D409/14 , A61K31/53 , A61K31/4985 , A61K31/4427 , A61P35/00 , A61K31/5377 , A61K31/5513 , C07D519/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5513 , C07D409/04 , C07D409/14 , C07D519/00
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
摘要翻译： 本发明涉及具有蛋白酪氨酸激酶抑制活性的新的取代的5-（1-苯并噻吩-2-基）吡咯并[2,1-f] [1,2,4]三嗪-4-胺衍生物，其制备方法 的这些化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗增殖性疾病，特别是癌症和肿瘤疾病的用途。
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公开(公告)号：US09206184B2
公开(公告)日：2015-12-08
申请号：US13715553
申请日：2012-12-14
发明人： Dirk Brohm , Melanie Heroult , Marie-Pierre Collin , Walter Hübsch , Mario Lobell , Klemens Lustig , Sylvia Grünewald , Ulf Bömer
IPC分类号： C07D487/04 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.
摘要翻译： 本发明涉及具有蛋白酪氨酸激酶抑制活性的新的取代的5-（1-苯并噻吩-2-基）吡咯并[2,1-f] [1,2,4]三嗪-4-胺衍生物，其制备方法 的这些化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗增殖性疾病，特别是癌症和肿瘤疾病的用途。
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