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公开(公告)号：US20150183773A1
公开(公告)日：2015-07-02
申请号：US14643209
申请日：2015-03-10
发明人： Mario JESKE , Dirk HEIMBACH , Susanne RÖHRIG , Yolanda CANCHO GRANDE , Dirk SCHNEIDER , Ulrich RESTER , Eckhard BENDER , Mark MEININGHAUS , Katja ZIMMERMANN , Dmitry ZUBOV , Anja BUCHMÜLLER , Georges VON DEGENFELD , Christoph GERDES , Michael GERISCH , Mark Jean GNOTH , Kersten Matthias GERICKE
IPC分类号： C07D417/06 , A61K31/451 , C07D405/06 , A61K31/453 , A61K31/4525 , A61K31/541 , C07D401/06 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/496 , C07D211/60 , A61K31/4523
CPC分类号： C07D417/06 , A61K9/0019 , A61K9/10 , A61K9/2018 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/10 , A61K47/36 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders and tumour disorders.
摘要翻译： 本发明涉及新的取代的哌啶，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管疾病和肿瘤的药物的用途 疾病
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公开(公告)号：US20200339567A1
公开(公告)日：2020-10-29
申请号：US16758751
申请日：2018-10-18
发明人： Daniel MEIBOM , Jutta MEYER , Karl COLLINS , Nuria ORTEGA HERNANDEZ , Jan STAMPFUSS , Frank WUNDER , Till FREUDENBERGER , Thomas MONDRITZKI , Nina Alexandra SCHEERER , Kirsten LEINEWEBER , Jens SCHAMBERGER , Alexander STRAUB , Kersten Matthias GERICKE , Walter KROH , Mario LOBELL , Klaus MÜNTER
IPC分类号： C07D471/04 , C07D519/00 , A61K31/444 , A61K45/06 , A61P9/10 , A61K31/437
摘要： The present application relates to novel substituted imidazopyridine amides of the formula (I), to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular, neurological and central nervous as well as metabolic disorders.
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公开(公告)号：US20160137647A1
公开(公告)日：2016-05-19
申请号：US14895793
申请日：2014-05-30
发明人： Swen ALLERHEILlGEN , Anja BUCHMÜLLER , Karen ENGEL , Christoph GERDES , Kersten Matthias GERICKE , Michael GERISCH , Stefan HEITMEIER , Alexander HILLlSCH , Tom KINZEL , Philip LIENAU , Bernd RIEDL , Susanne RÖHRIG , Martina Victoria SCHMIDT , Julia STRASSBURGER , Adrian TERSTEEGEN
IPC分类号： C07D487/04 , A61K31/454 , A61K31/495 , A61K31/5386 , A61K31/4985 , A61K31/423 , C07D413/06 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/423 , A61K31/454 , A61K31/495 , A61K31/4985 , A61K31/5377 , A61K31/5386 , C07D263/58 , C07D413/06 , C07D417/06
摘要： The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.
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4.发明申请TRIAZOLOPYRIDINES AS THROMBIN INHIBITORS FOR THE TREATMENT OF THROMBOEMBOLIC DISEASES 审中-公开三唑吡啶作为治疗血栓性疾病的血栓抑制剂公开(公告)号：US20160108039A1
公开(公告)日：2016-04-21
申请号：US14895675
申请日：2014-06-02
发明人： Swen ALLERHEILlGEN , Anja BUCHMÜLLER , Karen ENGEL , Christoph GERDES , Kersten Matthias GERICKE , Michael GERISCH , Stefan HEITMEIER , Alexander HILLlSCH , Tom KINZEL , Philip LIENAU , Bernd RIEDL , Susanne RÖHRIG , Martina Victoria SCHMIDT , Julia STRASSBURGER , Adrian TERSTEEGEN
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D519/00
摘要： The invention relates to substituted triazolopyridines and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.
摘要翻译： 本发明涉及取代的三唑并吡啶及其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞障碍的药物的用途。
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![SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3(2H)-ONES AND 2,5,6,7-TETRAHYDRO-3H-PYRROLO[2,1-C][1,2,4]TRIAZOL-3-ONES, AND USE THEREOF](/abs-image/US/2019/05/30/US20190160048A1/abs.jpg.150x150.jpg)
公开(公告)号：US20190160048A1
公开(公告)日：2019-05-30
申请号：US16300480
申请日：2017-05-08
发明人： Nicole BIBER , Damian BROCKSCHNIEDER , Kersten Matthias GERICKE , Florian KÖLLING , Klemens LUSTIG , Jörg MEDING , Heinrich MEIER , Thomas NEUBAUER , Martina SCHÄFER , Andreas TIMMERMANN , Dmitry ZUBOV , Carsten TERJUNG , Niels LINDNER , Volker BADOCK , Dieter MOOSMAYER , Hideki MIYATAKE ONDOZABAL , Steven MOORE , Alexander SCHULZ
IPC分类号： A61K31/437 , A61P29/00 , A61P11/00 , C07D471/04 , A61K31/506
摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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公开(公告)号：US20160108027A1
公开(公告)日：2016-04-21
申请号：US14895625
申请日：2014-05-30
发明人： Swen ALLERHEILlGEN , Anja BUCHMÜLLER , Karen ENGEL , Christoph GERDES , Kersten Matthias GERICKE , Michael GERISCH , Stefan HEITMEIER , Alexander HILLlSCH , Tom KINZEL , Philip LIENAU , Bernd RIEDL , Susanne RÖHRIG , Martina Victoria SCHMIDT , Julia STRASSBURGER , Adrian TERSTEEGEN
IPC分类号： C07D413/14 , C07D487/04
CPC分类号： C07D413/14 , C07D413/12 , C07D487/04
摘要： The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.
摘要翻译： 本发明涉及取代的苯并恶唑及其制备方法及其制备药物用途，用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病。
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公开(公告)号：US20190144431A1
公开(公告)日：2019-05-16
申请号：US16098238
申请日：2017-05-02
发明人： Heiko SCHIRMER , Philipp RUBENBAUER , Hans-Christian MILITZER , Marie-Pierre COLLIN-KRÖPELIN , Frank SÜßMEIER , Kersten Matthias GERICKE , Thomas NEUBAUER , Chantal FÜRSTNER
IPC分类号： C07D403/06 , C07D249/12
摘要： The present application relates to a novel and improved process for preparing 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives of the formula (I) in which R1A and R1B are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl, monofluoromethyl, difluoromethyl, trifluoromethyl, ethyl, methoxy, difluoromethoxy and trifluoromethoxy, to novel precursors for preparation thereof, and to the preparation and use of the crystalline polymorph I of (5-(4-chlorophenyl)-2-({1-(3-chlorophenyl)-5-[(1S)-1-hydroxyethyl]-1H-1,2,4-triazol-3-yl}methyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I-A-1).
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公开(公告)号：US20170253602A1
公开(公告)日：2017-09-07
申请号：US15529043
申请日：2015-11-23
发明人： Andreas SCHALL , Jürgen KLAR , Mario LOBELL , Hartmut SCHIROK , Joachim TELSER , Steffen MÜLLER , Dirk BROHM , Hans BRIEM , Hannah JÖRIßEN , Joerg KELDENICH (deceased) , Michael BÖTTGER , Georges DEGENFELD VON , Thomas SCHLANGE , Ulf BÖMER , Niels LINDNER , Hanna EILKEN , Dmitrij HRISTODOROV , Pierre WASNAIRE , Kersten Matthias GERICKE , Lars BÄRFACKER
IPC分类号： C07D487/04 , A61K39/395 , A61K31/5513
CPC分类号： C07D487/04 , A61K31/5513 , A61K39/39558
摘要： The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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