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公开(公告)号：US20190144431A1
公开(公告)日：2019-05-16
申请号：US16098238
申请日：2017-05-02
发明人： Heiko SCHIRMER , Philipp RUBENBAUER , Hans-Christian MILITZER , Marie-Pierre COLLIN-KRÖPELIN , Frank SÜßMEIER , Kersten Matthias GERICKE , Thomas NEUBAUER , Chantal FÜRSTNER
IPC分类号： C07D403/06 , C07D249/12
摘要： The present application relates to a novel and improved process for preparing 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives of the formula (I) in which R1A and R1B are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl, monofluoromethyl, difluoromethyl, trifluoromethyl, ethyl, methoxy, difluoromethoxy and trifluoromethoxy, to novel precursors for preparation thereof, and to the preparation and use of the crystalline polymorph I of (5-(4-chlorophenyl)-2-({1-(3-chlorophenyl)-5-[(1S)-1-hydroxyethyl]-1H-1,2,4-triazol-3-yl}methyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I-A-1).
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公开(公告)号：US20190144422A1
公开(公告)日：2019-05-16
申请号：US16098202
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Carsten SCHMECK , Pierre WASNAIRE , Hanna TINEL , Heiko SCHIRMER
IPC分类号： C07D401/14 , A61K31/4196 , C07D417/14 , C07D403/14 , A61K45/06 , A61K31/4439 , A61K31/427 , A61K31/497 , A61K31/501 , A61P13/12 , A61P9/12 , A61P9/10
CPC分类号： C07D401/14 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K45/06 , A61P9/10 , A61P9/12 , A61P13/12 , C07D403/14 , C07D417/14
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-heteroaryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190161454A1
公开(公告)日：2019-05-30
申请号：US16098266
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D249/12 , A61K45/06 , A61K31/4196 , A61P9/00 , A61P13/12
摘要： The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190144423A1
公开(公告)日：2019-05-16
申请号：US16098308
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61P13/12 , A61P9/04 , A61P9/10 , A61P3/10
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190142804A1
公开(公告)日：2019-05-16
申请号：US16098255
申请日：2017-05-02
发明人： Thomas NEUBAUER , Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER
IPC分类号： A61K31/4196 , C07D401/14 , C07D403/06 , C07D405/14 , A61K45/06 , A61K31/4439 , A61P9/10 , A61P13/12
CPC分类号： A61K31/4196 , A61K31/4439 , A61K45/06 , A61P9/10 , A61P13/12 , C07D249/12 , C07D401/14 , C07D403/06 , C07D405/14
摘要： The present invention relates to novel 5-(fluoroalkyl)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190119251A1
公开(公告)日：2019-04-25
申请号：US16098262
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA , Axel KRETSCHMER
IPC分类号： C07D401/14 , A61K45/06 , A61K31/4439 , C07D403/14 , A61K31/497 , A61K31/506 , C07D403/06 , A61K31/4196
摘要： The present invention relates to novel 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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