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公开(公告)号：US20200338096A1
公开(公告)日：2020-10-29
申请号：US16758742
申请日：2018-10-17
发明人： Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FUERSTNER , Elisabeth POOK , Matthias Beat WITTWER , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER , Hana CERNECKA , Karoline DROEBNER , Hanna TINEL , Anja BUCHMUELLER , Thomas MONDRITZKI , Axel KRETSCHMER , Klemens LUSTIG , Robert FRICKE , Guillaume LEVILAIN , Ursula KRENZ , Norbert WITOWSKI
IPC分类号： A61K31/675 , A61K45/06 , C07F9/6558 , A61P13/12
摘要： The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20230065629A1
公开(公告)日：2023-03-02
申请号：US17519329
申请日：2021-11-04
发明人： Anja GIESE , Jürgen KLAR , Alexander Helmut Michael EHRMANN , Jens WILLWACHER , David ENGEL , Andre Philippe DIESKAU , Antje KAHNERT , Alexey GROMOV , Carsten SCHMECK , Niels LINDNER , Thomas MÜLLER , Anna Lena ANDREEVSKI , Jan DREHER , Karl COLLINS
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20190144422A1
公开(公告)日：2019-05-16
申请号：US16098202
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Carsten SCHMECK , Pierre WASNAIRE , Hanna TINEL , Heiko SCHIRMER
IPC分类号： C07D401/14 , A61K31/4196 , C07D417/14 , C07D403/14 , A61K45/06 , A61K31/4439 , A61K31/427 , A61K31/497 , A61K31/501 , A61P13/12 , A61P9/12 , A61P9/10
CPC分类号： C07D401/14 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K45/06 , A61P9/10 , A61P9/12 , A61P13/12 , C07D403/14 , C07D417/14
摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-heteroaryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20200055842A1
公开(公告)日：2020-02-20
申请号：US16341410
申请日：2017-10-09
发明人： Anja GIESE , Jürgen KLAR , Alexander Helmut Michael EHRMANN , Jens WILLWACHER , David ENGEL , Andre Philippe DIESKAU , Antje KAHNERT , Alexey GROMOV , Carsten SCHMECK , Niels LINDNER , Thomas MÜLLER , Anna Lena ANDREEVSKI , Jan DREHER , Karl COLLINS
IPC分类号： C07D403/14 , C07D401/14 , C07D487/04 , C07D405/14 , C07D413/14
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20190315720A1
公开(公告)日：2019-10-17
申请号：US16343150
申请日：2017-10-16
发明人： Chantal FUERSTNER , Marie-Pierre COLLIN-KROEPELIN , Peter KOLKHOF , Thomas NEUBAUER , Elisabeth POOK , Heiko SCHIRMER , Carsten SCHMECK , Pierre WASNAIRE , Matthias Beat WITTWER
IPC分类号： C07D403/06 , C07D403/14 , A61P13/12
摘要： The present invention relates to novel 3-(hydroxyalkyl)-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and/or cardiovascular diseases.
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公开(公告)号：US20180141931A1
公开(公告)日：2018-05-24
申请号：US15847684
申请日：2017-12-19
发明人： Eva Maria BECKER-PELSTER , Philipp BUCHGRABER , Anja BUCHMÜLLER , Karen ENGEL , Volker GEISS , Andreas GÖLLER , Herbert HIMMEL , Raimund KAST , Andreas KNORR , Dieter LANG , Gorden REDLICH , Carsten SCHMECK , Hanna TINEL , Frank WUNDER
IPC分类号： C07D401/14 , A61K45/06 , A61K31/541 , A61K31/5377 , C07D491/107 , C07D417/14 , C07D413/14 , A61K31/506
摘要： The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
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公开(公告)号：US20190161454A1
公开(公告)日：2019-05-30
申请号：US16098266
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D249/12 , A61K45/06 , A61K31/4196 , A61P9/00 , A61P13/12
摘要： The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190144423A1
公开(公告)日：2019-05-16
申请号：US16098308
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Axel KRETSCHMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA
IPC分类号： C07D401/14 , A61P13/12 , A61P9/04 , A61P9/10 , A61P3/10
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190142804A1
公开(公告)日：2019-05-16
申请号：US16098255
申请日：2017-05-02
发明人： Thomas NEUBAUER , Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Carsten SCHMECK , Pierre WASNAIRE , Heiko SCHIRMER
IPC分类号： A61K31/4196 , C07D401/14 , C07D403/06 , C07D405/14 , A61K45/06 , A61K31/4439 , A61P9/10 , A61P13/12
CPC分类号： A61K31/4196 , A61K31/4439 , A61K45/06 , A61P9/10 , A61P13/12 , C07D249/12 , C07D401/14 , C07D403/06 , C07D405/14
摘要： The present invention relates to novel 5-(fluoroalkyl)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US20190119251A1
公开(公告)日：2019-04-25
申请号：US16098262
申请日：2017-05-02
发明人： Marie-Pierre COLLIN-KRÖPELIN , Peter KOLKHOF , Thomas NEUBAUER , Chantal FÜRSTNER , Elisabeth POOK , Matthias Beat WITTWER , Klemens LUSTIG , Anja BUCHMÜLLER , Hanna TINEL , Karoline DRÖBNER , Thomas MONDRITZKI , Heiko SCHIRMER , Carsten SCHMECK , Pierre WASNAIRE , Hana CERNECKA , Axel KRETSCHMER
IPC分类号： C07D401/14 , A61K45/06 , A61K31/4439 , C07D403/14 , A61K31/497 , A61K31/506 , C07D403/06 , A61K31/4196
摘要： The present invention relates to novel 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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