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![CYANO-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINECARBOXAMIDES AND THEIR USE](/abs-image/US/2017/08/03/US20170217954A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170217954A1
公开(公告)日：2017-08-03
申请号：US15120377
申请日：2015-03-18
发明人： Alexandros VAKALOPOULOS , Philipp BUCHGRABER , Niels LINDNER , Markus FOLLMANN , Frank WUNDER , Johannes-Peter STASCH , Tobias MARQUARDT , Gorden REDLICH , Lisa DIETZ , Volkhart Min-Jian LI
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/444 , A61K45/06 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20160244461A1
公开(公告)日：2016-08-25
申请号：US15027519
申请日：2014-10-02
发明人： Michael HÄRTER , Martina DELBECK , Bernd KALTHOF , Klemens LUSTIG , Niels LINDNER , Raimund KAST , Pierre WASNAIRE , Frank SÜßMEIER
IPC分类号： C07D495/04 , A61K31/519 , C07D519/00 , A61K45/06
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07D519/00
摘要： The present application relates to novel 2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives (“thienouracil”-carboxamides), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for the preparation of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiovascular disorders.
摘要翻译： 本申请涉及新的2,4-二氧代-1,2,3,4-四氢噻吩并[2,3-d]嘧啶-6-甲酰胺衍生物（“噻吩尿嘧啶” - 羧酰胺），其制备方法， 单独使用或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是用于治疗和/或预防肺和心血管疾病的药物的用途。
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![Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2014/05/08/US20140128425A1/abs.jpg.150x150.jpg)
公开(公告)号：US20140128425A1
公开(公告)日：2014-05-08
申请号：US13789414
申请日：2013-03-07
发明人： Alexandros VAKALOPOULOS , Ingo HARTUNG , Markus FOLLMANN , Rolf JAUTELAT , Niels LINDNER , Dirk SCHNEIDER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI
IPC分类号： A61K31/437 , A61K45/06 , C07D471/04
CPC分类号： C07D401/10 , A61K31/4353 , A61K31/437 , A61K45/06 , C07D401/02 , C07D471/04
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20230065629A1
公开(公告)日：2023-03-02
申请号：US17519329
申请日：2021-11-04
发明人： Anja GIESE , Jürgen KLAR , Alexander Helmut Michael EHRMANN , Jens WILLWACHER , David ENGEL , Andre Philippe DIESKAU , Antje KAHNERT , Alexey GROMOV , Carsten SCHMECK , Niels LINDNER , Thomas MÜLLER , Anna Lena ANDREEVSKI , Jan DREHER , Karl COLLINS
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20170145029A1
公开(公告)日：2017-05-25
申请号：US15423447
申请日：2017-02-02
发明人： Michael HÄRTER , Martina DELBECK , Bernd KALTHOF , Klemens LUSTIG , Niels LINDNER , Raimund KAST , Pierre WASNAIRE , Frank SÜßMEIER
IPC分类号： C07D495/04 , A61K31/519 , C07D519/00 , A61K45/06
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , C07D519/00
摘要： The present application relates to novel 2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives (“thienouracil”-carboxamides), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for the preparation of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of pulmonary and cardiovascular disorders.
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![ARYL- AND HETARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDES AND USE THEREOF](/abs-image/US/2016/12/15/US20160362408A1/abs.jpg.150x150.jpg)
6.发明申请ARYL- AND HETARYL-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDES AND USE THEREOF 审中-公开芳基和取代的咪唑并[1,2-A]吡啶-3-羧酸及其用途公开(公告)号：US20160362408A1
公开(公告)日：2016-12-15
申请号：US15038914
申请日：2014-12-01
发明人： Alexandros VAKALOPOULOS , Ingo HARTUNG , Niels LINDNER , Rolf JAUTELAT , Jorma HASSFELD , Dirk SCHNEIDER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI , Eva Maria BECKER-PELSTER , Andreas KNORR
IPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/538 , A61K31/4545 , A61K31/4709 , A61K31/502 , A61K31/496 , A61K31/506 , A61K31/541 , A61K31/5377
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/502 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/541
摘要： The present application relates to novel aryl- and hetaryl-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新颖的芳基和杂芳基取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独或组合用于治疗和/或预防疾病 以及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病的药物。
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![SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF](/abs-image/US/2016/06/23/US20160176880A1/abs.jpg.150x150.jpg)
公开(公告)号：US20160176880A1
公开(公告)日：2016-06-23
申请号：US14910519
申请日：2014-08-05
发明人： Alexandros VAKALOPOULOS , Markus FOLLMANN , Ingo HARTUNG , Philipp BUCHGRABER , Rolf JAUTELAT , Niels LINDNER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Lisa Dietz , Volkhart Min-Jian LI
IPC分类号： C07D487/04 , A61K31/5377 , A61K31/4985 , C07D519/00 , A61K45/06
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06 , C07D519/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyrazinecarboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型取代的咪唑并[1,2-a]吡嗪甲酰胺，其制备方法，单独或组合用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
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![Hydroxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2014/05/08/US20140128386A1/abs.jpg.150x150.jpg)
8.发明申请公开(公告)号：US20140128386A1
公开(公告)日：2014-05-08
申请号：US14071274
申请日：2013-11-04
发明人： Alexandros VAKALOPOULOS , Ingo HARTUNG , Markus FOLLMANN , Rolf JAUTELAT , Alexander STRAUB , Jorma HAßFELD , Niels LINDNER , Dirk SCHNEIDER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI , Eva Maria BECKER-PELSTER , Andreas KNORR
IPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K31/444 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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![Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use](/abs-image/US/2014/05/08/US20140128372A1/abs.jpg.150x150.jpg)
9.发明申请公开(公告)号：US20140128372A1
公开(公告)日：2014-05-08
申请号：US13789655
申请日：2013-03-07
发明人： Alexandros VAKALOPOULOS , Markus FOLLMANN , Ingo HARTUNG , Philipp BUCHGRABER , Rolf JAUTELAT , Jorma HAßFELD , Niels LINDNER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI , Eva-Maria BECKER , Andreas KNORR
IPC分类号： C07D471/04 , A61K45/06 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/439 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , A61K2300/00
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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10.发明申请公开(公告)号：US20220017540A1
公开(公告)日：2022-01-20
申请号：US17305927
申请日：2021-07-16
发明人： Martina DELBECK , Michael HAHN , Thomas MÜLLER , Klemens LUSTIG , Karl COLLINS , Niels LINDNER , Janine NICOLAI , Moritz BECK-BROICHSITTER , Udo ALBUS , Doris GEHRING , Björn ROSENSTEIN
IPC分类号： C07D519/00 , A61P11/00
摘要： The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.
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