公开(公告)号：US20220017540A1

公开(公告)日：2022-01-20

申请号：US17305927

申请日：2021-07-16

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Martina DELBECK ,  Michael HAHN ,  Thomas MÜLLER ,  Klemens LUSTIG ,  Karl COLLINS ,  Niels LINDNER ,  Janine NICOLAI ,  Moritz BECK-BROICHSITTER ,  Udo ALBUS ,  Doris GEHRING ,  Björn ROSENSTEIN

IPC分类号： C07D519/00 ,  A61P11/00

摘要： The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

公开(公告)号：US20210024545A1

公开(公告)日：2021-01-28

申请号：US16319106

申请日：2017-07-10

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Martina DELBECK ,  Michael HAHN ,  Thomas MÜLLER ,  Klemens LUSTIG ,  Johanna ANLAHR ,  Udo ALBUS ,  Doris GEHRING ,  Björn ROSENSTEIN ,  Karl COLLINS ,  Niels LINDNER ,  Janine NICOLAI ,  Moritz BECK-BROICHSITTER

IPC分类号： C07D519/00 ,  A61K45/06 ,  A61K9/00 ,  A61K31/439 ,  A61K31/444 ,  A61K31/5386 ,  A61K31/55 ,  A61P11/00 ,  G16C20/64 ,  A61K31/5377 ,  A61K9/08

摘要： The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1-and/or TASK-3-blocking properties.

公开(公告)号：US20200085734A1

公开(公告)日：2020-03-19

申请号：US16471263

申请日：2017-12-13

申请人： Bayer Pharma Aktiengesellschaft

发明人： Johanna ANLAHR ,  Moritz BECK-BROICHSITTER ,  Janine NICOLAI ,  Martina DELBECK ,  Michael HAHN ,  Udo ALBUS ,  Doris GEHRING ,  Björn ROSENSTEIN

IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K31/496 ,  A61K47/26

摘要： The invention relates to new pharmaceutical dosage forms containing potent and selective TASK-1 and/or TASK-3 channel inhibitors, and the use of same to treat and/or prevent breathing disorders including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

公开(公告)号：US20200093737A1

公开(公告)日：2020-03-26

申请号：US16472116

申请日：2017-12-13

申请人： Bayer Pharma Aktiengesellschaft

发明人： Johanna ANLAHR ,  Moritz BECK-BROICHSITTER ,  Janine NICOLAI ,  Martina DELBECK ,  Michael HAHN ,  Udo ALBUS ,  Doris GEHRING ,  Björn ROSENSTEIN

IPC分类号： A61K9/00 ,  A61K47/10 ,  A61K31/496

摘要： The invention relates to new pharmaceutical dosage forms containing potent and selective TASK-1 and/or TASK-3 channel inhibitors, and the use of same to treat and/or prevent breathing disorders including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring.

公开(公告)号：US20190062326A1

公开(公告)日：2019-02-28

申请号：US15756867

申请日：2016-12-07

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Martina DELBECK ,  Michael HAHN ,  Thomas MÜLLER ,  Heinrich MEIER ,  Klemens LUSTIG ,  Johanna MOSIG ,  Luisella TOSCHI ,  Udo ALBUS ,  Doris GEHRING ,  Björn ROSENSTEIN

IPC分类号： C07D471/04 ,  A61K31/496 ,  A61K45/06 ,  A61P11/16

摘要： The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.

公开(公告)号：US20180370965A1

公开(公告)日：2018-12-27

申请号：US15781848

申请日：2016-12-02

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Martina DELBECK ,  Michael HAHN ,  Thomas MÜLLER ,  Heinrich MEIER ,  Klemens LUSTIG ,  Johanna MOSIG ,  Luisella TOSCHI ,  Udo ALBUS ,  Doris GEHRING ,  Björn ROSENSTEIN

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61P11/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K45/06 ,  A61P11/00 ,  C07D519/00

摘要： The present application relates to novel (2-phenylimidazo[1,2-a]pyridin-3-yl)methyl-substituted perhydropyrrolo[3,4-c]pyrrole derivatives, to methods for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apneas and central sleep apneas and snoring.