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公开(公告)号：US20170020875A1
公开(公告)日：2017-01-26
申请号：US15288982
申请日：2016-10-07
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/506 , A61K45/06 , C07D405/14 , C07D413/04 , A61K31/538 , C07D401/04 , A61K31/536 , C07D409/14 , C07D417/14 , C07D403/04 , C07D417/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US20160221965A1
公开(公告)日：2016-08-04
申请号：US15021372
申请日：2014-09-12
发明人： Alexander STRAUB , Marie-Pierre COLLIN , Michael KOCH , Jutta MEYER , Karl-Heinz SCHLEMMER , Carl Friedrich NISING , Nicole BIBER , Sonja ANLAUF , Matthias Beat WITTWER
IPC分类号： C07D239/47 , A61K45/06 , C07D401/12 , C07D239/56 , C07D239/36 , C07D401/06 , A61K31/513 , C07D239/52
CPC分类号： C07D239/47 , A61K31/513 , A61K45/06 , C07D239/36 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/56 , C07D401/06 , C07D401/12
摘要： The present application relates to novel 2,5-disubstituted 6-(trifluoromethyl)pyrimidin-4(3H)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.
摘要翻译： 本申请涉及新的2,5-二取代的6-（三氟甲基）嘧啶-4（3H） - 酮衍生物，其制备方法单独使用或组合用于治疗和/或预防疾病，以及 用于制备用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管，肾，炎症和纤维化疾病。
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公开(公告)号：US20210261541A1
公开(公告)日：2021-08-26
申请号：US17161201
申请日：2021-01-28
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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![Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use](/abs-image/US/2014/05/08/US20140128424A1/abs.jpg.150x150.jpg)
4.发明申请Hydroxy-substituted imidazo[1,2-a]-pyridinecarboxamides and their use 有权羟基取代的咪唑并[1,2-a] - 吡啶甲酰胺及其用途公开(公告)号：US20140128424A1
公开(公告)日：2014-05-08
申请号：US13789208
申请日：2013-03-07
发明人： Alexandros VAKALOPOULOS , Ingo HARTUNG , Markus FOLLMANN , Rolf JAUTELAT , Alexander STRAUB , Jorma HASSFELD , Niels LINDNER , Dirk SCHNEIDER , Frank WUNDER , Johannes-Peter STASCH , Gorden REDLICH , Volkhart Min-Jian LI , Eva-Maria BECKER , Andreas KNORR
IPC分类号： A61K31/437 , A61K45/06 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
摘要： The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的咪唑并[1,2-a]吡啶-3-甲酰胺，其制备方法单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20190241562A1
公开(公告)日：2019-08-08
申请号：US16317322
申请日：2017-07-04
发明人： Henrik TELLER , Melissa BOULTADAKIS ARAPINIS , Alexandros VAKALOPOULOS , Anne-Sophie REBSTOCK , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Klaus MÜNTER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/04 , A61P13/12 , A61P9/06
摘要： The present application relates to novel 7-substituted 1-pyridylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20170020876A1
公开(公告)日：2017-01-26
申请号：US15288968
申请日：2016-10-07
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , A61K31/538
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
摘要翻译： 本申请涉及新颖的双环取代的尿嘧啶衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产用于治疗和/或预防 疾病
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公开(公告)号：US20160237059A1
公开(公告)日：2016-08-18
申请号：US15021559
申请日：2014-09-12
发明人： Alexander STRAUB , Marie-Pierre COLLIN , Michael KOCH , Jutta MEYER , Karl-Heinz SCHLEMMER , Carl Friedrich NISING , Nicole BIBER , Sonja ANLAUF , Alexey GROMOV , Matthias Beat WITTWER
IPC分类号： C07D401/04 , A61K31/513 , C07D411/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D413/06 , C07D403/06 , C07D401/06 , C07D409/06 , C07D401/12 , C07D403/12 , C07D413/12 , C07D405/06 , C07D417/06 , C07D471/04 , C07D405/12 , A61K31/5377 , C07D239/36 , A61K45/06
CPC分类号： C07D401/04 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K45/06 , C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D411/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D471/04
摘要： The present application relates to novel heterocyclically substituted 6-(trifluoromethyl)pyrimidin-4(3H)-one derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of cardiovascular, renal, inflammatory and fibrotic diseases.
摘要翻译： 本申请涉及新的杂环取代的6-（三氟甲基）嘧啶-4（3H） - 酮衍生物，其制备方法单独使用或组合用于治疗和/或预防疾病及其用途 用于制备用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管，肾，炎症和纤维化疾病。
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公开(公告)号：US20220089591A1
公开(公告)日：2022-03-24
申请号：US17161186
申请日：2021-01-28
发明人： Henrik TELLER , Alexandros VAKALOPOULOS , Melissa BOULTADAKIS ARAPINIS , Alexander STRAUB , Hanna TINEL , Markus BRECHMANN , Matthias Beat WITTWER , Maximillian Andreas KULLMANN , Till FREUDENBERGER , Thomas MONDRITZKI , Tobias MARQUARDT
IPC分类号： C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/551 , A61K45/06 , C07D491/107 , C07D519/00 , A61P9/00 , A61P13/00
摘要： The present application relates to novel 7-substituted 1-arylnaphthyridine-3-carboxamides, to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prevention of diseases, and to their use for the production of medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders and/or renal disorders.
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公开(公告)号：US20200339567A1
公开(公告)日：2020-10-29
申请号：US16758751
申请日：2018-10-18
发明人： Daniel MEIBOM , Jutta MEYER , Karl COLLINS , Nuria ORTEGA HERNANDEZ , Jan STAMPFUSS , Frank WUNDER , Till FREUDENBERGER , Thomas MONDRITZKI , Nina Alexandra SCHEERER , Kirsten LEINEWEBER , Jens SCHAMBERGER , Alexander STRAUB , Kersten Matthias GERICKE , Walter KROH , Mario LOBELL , Klaus MÜNTER
IPC分类号： C07D471/04 , C07D519/00 , A61K31/444 , A61K45/06 , A61P9/10 , A61K31/437
摘要： The present application relates to novel substituted imidazopyridine amides of the formula (I), to processes for their preparation, to their use, alone or in combinations, for the treatment and/or prophylaxis of diseases and to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular, neurological and central nervous as well as metabolic disorders.
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公开(公告)号：US20200061063A1
公开(公告)日：2020-02-27
申请号：US16373487
申请日：2019-04-02
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/506 , A61K31/536
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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