公开(公告)号：US10265315B2

公开(公告)日：2019-04-23

申请号：US15480731

申请日：2017-04-06

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Jin Wang ,  Jianming Xu ,  Jianwei Chen

IPC: C07D401/12 ,  C07D403/12 ,  A61K31/506 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/4402 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

公开(公告)号：US11312676B2

公开(公告)日：2022-04-26

申请号：US15540386

申请日：2015-12-29

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： David Michael Lonard ,  Lei Wang ,  Bert W. O'Malley ,  Jianming Xu ,  Yongcheng Song ,  Xiaonan Li ,  Timothy Gerald Palzkill

IPC: C07C49/753 ,  A61K31/444 ,  A61K31/45 ,  A61K31/4402 ,  A61K31/351 ,  A61K31/4433 ,  A61K31/122 ,  A61K31/4545 ,  C07D401/06 ,  C07D309/38 ,  C07D405/06 ,  C07D213/68 ,  C07D405/12 ,  A61P35/00 ,  C07C49/697 ,  C07D211/86 ,  C07D213/50 ,  C07D309/32 ,  C07D401/14 ,  C07D405/14

Abstract: Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.

公开(公告)号：US20190216810A1

公开(公告)日：2019-07-18

申请号：US16361600

申请日：2019-03-22

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Jin Wang ,  Jianming Xu ,  Jianwei Chen

IPC: A61K31/506 ,  C07D498/04 ,  C07D487/04 ,  C07D471/04 ,  C07D417/12 ,  C07D413/12 ,  C07D409/12 ,  A61K31/4184 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  A61K31/4402 ,  A61K31/426 ,  C07D405/12

CPC classification number: A61K31/506 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/4402 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

公开(公告)号：US20170290830A1

公开(公告)日：2017-10-12

申请号：US15480731

申请日：2017-04-06

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Jin Wang ,  Jianming Xu ,  Jianwei Chen

IPC: A61K31/506 ,  A61K31/426 ,  A61K31/4402 ,  A61K31/4184

CPC classification number: A61K31/506 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/4402 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

公开(公告)号：US20200085824A1

公开(公告)日：2020-03-19

申请号：US16691195

申请日：2019-11-21

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Jin Wang ,  Jianming Xu ,  Jianwei Chen

IPC: A61K31/506 ,  C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/4402

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

公开(公告)号：US11253517B2

公开(公告)日：2022-02-22

申请号：US16691195

申请日：2019-11-21

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Jin Wang ,  Jianming Xu ,  Jianwei Chen

IPC: C07D417/12 ,  A61K31/506 ,  C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/4402

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

公开(公告)号：US10512647B2

公开(公告)日：2019-12-24

申请号：US16361600

申请日：2019-03-22

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： Bert W. O'Malley ,  David Michael Lonard ,  Jin Wang ,  Jianming Xu ,  Jianwei Chen

IPC: C07D401/12 ,  C07D403/12 ,  A61K31/506 ,  A61K31/4184 ,  A61K31/426 ,  A61K31/4402 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related diseases can include cancer, metabolic disorders, human immunodeficiency virus, neurodegenerative disorders, and/or inflammatory diseases. Also provided are methods for regulating SRC family proteins in a cell.

公开(公告)号：US20180265444A1

公开(公告)日：2018-09-20

申请号：US15540386

申请日：2015-12-29

Applicant: BAYLOR COLLEGE OF MEDICINE

Inventor： David Michael Lonard ,  Lei Wang ,  Bert W. O'Malley ,  Jianming Xu ,  Yongcheng Song ,  Xiaonan Li ,  Timothy Gerald Palzkill

IPC: C07C49/753 ,  A61P35/00 ,  C07C49/697 ,  C07D213/50 ,  C07D309/32 ,  C07D405/14 ,  C07D211/86 ,  C07D401/14

CPC classification number: C07C49/753 ,  A61K31/122 ,  A61K31/351 ,  A61K31/4402 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/45 ,  A61K31/4545 ,  A61P35/00 ,  C07C49/697 ,  C07C2601/14 ,  C07D211/86 ,  C07D213/50 ,  C07D213/68 ,  C07D309/32 ,  C07D309/38 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14

Abstract: Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.