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公开(公告)号：US09678073B2
公开(公告)日：2017-06-13
申请号：US14366024
申请日：2012-12-21
IPC分类号： G01N33/569 , G01N33/50
CPC分类号： G01N33/56972 , G01N33/5091 , G01N33/5094 , G01N2333/70514 , G01N2333/70589 , G01N2333/70596 , G01N2333/91205
摘要： The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.
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公开(公告)号：US20230288416A1
公开(公告)日：2023-09-14
申请号：US18124224
申请日：2023-03-21
IPC分类号： G01N33/569 , G01N33/50
CPC分类号： G01N33/56972 , G01N33/5091 , G01N33/5094 , G01N1/30
摘要： The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.
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公开(公告)号：US11635433B2
公开(公告)日：2023-04-25
申请号：US15188856
申请日：2016-06-21
IPC分类号： G01N33/569 , G01N1/30
摘要： The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.
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公开(公告)号：US20180172564A1
公开(公告)日：2018-06-21
申请号：US15899072
申请日：2018-02-19
发明人： Andreas Van Agthoven
IPC分类号： G01N1/30
CPC分类号： G01N1/30
摘要： The present invention relates to a cell treatment composition for the permeabilization of fixed blood cells, to the use of said composition, to a method for the treatment of a biological sample comprising fixation of said sample and subsequently contacting said biological sample with said cell treatment composition. The invention further relates and to a kit comprising said cell treatment composition.
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公开(公告)号：US09903795B2
公开(公告)日：2018-02-27
申请号：US14139158
申请日：2013-12-23
发明人： Andreas Van Agthoven
CPC分类号： G01N1/30
摘要： The present invention relates to a cell treatment composition for the permeabilization of fixed blood cells, to the use of said composition, to a method for the treatment of a biological sample comprising fixation of said sample and subsequently contacting said biological sample with said cell treatment composition. The invention further relates and to a kit comprising said cell treatment composition.
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公开(公告)号：US10739357B2
公开(公告)日：2020-08-11
申请号：US15510612
申请日：2015-09-11
摘要： Systems and methods are provided for determining the age of cellular hemoglobin in individual red blood cells in a blood sample by determining the percentage of HbA1c. In embodiments, a method includes measuring side scatter and fluorescence of the individual red blood cells and identifying immature red blood cells and mature red blood cells from the side scatter and fluorescence measurement. In embodiments, data collected includes the exact number of red blood cells, the fraction limits in fluorescence and side scatter units, the mean value of each fraction in fluorescence and side scatter units, the mean FL1 values per fraction in arbitrary units and the mean side scatter values per fraction in arbitrary units. In embodiments, a method also includes deriving a HbA1c content from the measured mean fluorescence of the individual red blood cells and determining the percentage of HbA1c from the HbA1c content and the hemoglobin content of the red blood cells.
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公开(公告)号：USRE45617E1
公开(公告)日：2015-07-21
申请号：US13800995
申请日：2013-03-13
IPC分类号： G01N33/96 , A01N1/02 , A61K35/407
CPC分类号： A61K35/407 , G01N33/721 , G01N33/96 , G01N2333/805 , G01N2496/10 , Y10T436/101666 , Y10T436/107497
摘要： A reference control for cell by cell analysis on flow cytometric analyzers contains cellular analogs made of permeated blood cells containing therein aggregated intracellular proteins and preserved antigenic sites thereof, having cellular membrane permeable to antibodies and a suspension medium. The reference control is frozen after being prepared and thawed prior to use. The cellular analogs further contain a fluorescence marker therein. Further disclosed are a method of making the reference control and a method using the reference control, as an internal or stand-alone control, for measurements of cellular hemoglobin and cellular hemoglobin variant of a blood sample.
摘要翻译： 用于流式细胞分析仪的细胞分析的参考对照包含由其中含有聚集的细胞内蛋白质和其保留的抗原位点的透过血细胞制成的细胞类似物，其具有可抗抗体的细胞膜和悬浮介质。 参考对照在使用前准备并解冻后冷冻。 细胞类似物还含有荧光标记物。 进一步公开的是进行参考控制的方法和使用参考对照作为血液样品的细胞血红蛋白和细胞血红蛋白变体的测量作为内部或独立控制的方法。
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公开(公告)号：US20150010923A1
公开(公告)日：2015-01-08
申请号：US14366024
申请日：2012-12-21
IPC分类号： G01N33/569
CPC分类号： G01N33/56972 , G01N33/5091 , G01N33/5094 , G01N2333/70514 , G01N2333/70589 , G01N2333/70596 , G01N2333/91205
摘要： The present invention relates to methods for labeling intracellular and extracellular targets of leukocytes, as well as to kits for performing said methods.
摘要翻译： 本发明涉及用于标记白细胞的细胞内和细胞外靶标的方法，以及用于进行所述方法的试剂盒。
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公开(公告)号：US20140186858A1
公开(公告)日：2014-07-03
申请号：US14139158
申请日：2013-12-23
发明人： Andreas Van Agthoven
IPC分类号： G01N1/30
CPC分类号： G01N1/30
摘要： The present invention relates to a cell treatment composition for the permeabilization of fixed blood cells, to the use of said composition, to a method for the treatment of a biological sample comprising fixation of said sample and subsequently contacting said biological sample with said cell treatment composition. The invention further relates and to a kit comprising said cell treatment composition.
摘要翻译： 本发明涉及用于固定血细胞透化的细胞处理组合物，所述组合物的用途，用于处理生物样品的方法，包括固定所述样品并随后使所述生物样品与所述细胞处理组合物接触 。 本发明还涉及一种包含所述细胞处理组合物的试剂盒。
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