公开(公告)号：US20230014629A1

公开(公告)日：2023-01-19

申请号：US17861710

申请日：2022-07-11

Applicant: Becton, Dickinson and Company

Inventor： Shreyas Bhaban ,  Peter Mage ,  Keegan Owsley ,  Wenyu Bai

IPC: G01J1/44 ,  G01N15/14

Abstract: Aspects of the present disclosure include methods for determining photodetector gain for a plurality of photodetectors in a light detection system. Methods according to certain embodiments include applying a reference voltage to each photodetector in the light detection system, generating a reference data signal for each photodetector at the reference voltage, irradiating with a light source the photodetectors at a plurality of different applied voltages, generating output data signals for each photodetector at each of the plurality of different voltages and calculating gain of the photodetectors at each of the plurality of different applied voltages based on the output data signals for each photodetector at each applied voltage and the reference data signal. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a plurality of photodetectors for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.

公开(公告)号：US20220136956A1

公开(公告)日：2022-05-05

申请号：US17512105

申请日：2021-10-27

Applicant: Becton, Dickinson and Company

Inventor： David Roberts ,  Peter Ludington Mage ,  Shreyas Bhaban

IPC: G01N15/14

Abstract: Aspects of the present disclosure include methods for determining a parameter of a photodetector (e.g., a photodetector in a particle analyzer). Methods according to certain embodiments include detecting light from a light source with a photodetector for a first predetermined time interval, detecting a step signal with the photodetector, the step signal indicating a change in a parameter of the light source or a parameter of the photodetector, detecting light from the light source for a second predetermined time interval, integrating data signals over the first predetermined time interval and the second predetermined time interval and determining one or more parameters of the photodetector based on the integrated data signals. Systems (e.g., particle analyzers) having a light source and a photodetector for practicing the subject methods are also described. Non-transitory computer readable storage medium having instructions stored thereon for determining a parameter of a photodetector according to the subject methods is also provided.

公开(公告)号：US11486812B2

公开(公告)日：2022-11-01

申请号：US17201700

申请日：2021-03-15

Applicant: Becton, Dickinson and Company

Inventor： Fedor Ilkov ,  Shreyas Bhaban

IPC: G01N15/10 ,  G01J1/44

Abstract: Aspects of the present disclosure include methods for determining a parameter of a photodetector (e.g., a photodetector in a particle analyzer). Methods according to certain embodiments include irradiating a photodetector positioned in a particle analyzer with a light source (e.g., a continuous wave light source) at a first intensity for a first predetermined time interval, irradiating the photodetector with the light source at a second intensity for a second predetermined time interval, integrating data signals from the photodetector over a period of time that includes the first predetermined interval and the second predetermined interval and determining one or more parameters of the photodetector based on the integrated data signals. Systems (e.g., particle analyzers) having light source and a photodetector for practicing the subject methods are also described. Non-transitory computer readable storage medium having instructions stored thereon for determining a parameter of a photodetector according to the subject methods are also provided.

公开(公告)号：US20210349005A1

公开(公告)日：2021-11-11

申请号：US17225347

申请日：2021-04-08

Applicant: Becton, Dickinson and Company

Inventor： Shreyas Bhaban ,  Peter Mage

IPC: G01N15/14

Abstract: Aspects of the present disclosure include methods for adjusting sensitivity of a photodiode in a light detection system. Methods according to certain embodiments include determining a background data signal from a photodetector at a plurality of detector gains, irradiating the photodetector with a light source at a plurality of different light intensities, generating data signals from the photodetector for the plurality of light intensities at each detector gain and adjusting the photodetector to the detector gain that corresponds to the lowest light irradiation intensity that generates a data signal resolvable from the background data signal. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodetector for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.

公开(公告)号：US20210325289A1

公开(公告)日：2021-10-21

申请号：US17201700

申请日：2021-03-15

Applicant: Becton, Dickinson and Company

Inventor： Fedor Ilkov ,  Shreyas Bhaban

IPC: G01N15/10

Abstract: Aspects of the present disclosure include methods for determining a parameter of a photodetector (e.g., a photodetector in a particle analyzer). Methods according to certain embodiments include irradiating a photodetector positioned in a particle analyzer with a light source (e.g., a continuous wave light source) at a first intensity for a first predetermined time interval, irradiating the photodetector with the light source at a second intensity for a second predetermined time interval, integrating data signals from the photodetector over a period of time that includes the first predetermined interval and the second predetermined interval and determining one or more parameters of the photodetector based on the integrated data signals. Systems (e.g., particle analyzers) having light source and a photodetector for practicing the subject methods are also described. Non-transitory computer readable storage medium having instructions stored thereon for determining a parameter of a photodetector according to the subject methods are also provided.

公开(公告)号：US11781964B2

公开(公告)日：2023-10-10

申请号：US17225347

申请日：2021-04-08

Applicant: Becton, Dickinson and Company

Inventor： Shreyas Bhaban ,  Peter Mage

IPC: G01N15/14 ,  G01J1/08 ,  G01N15/10

CPC classification number: G01N15/1429 ,  G01J1/08 ,  G01N15/1012 ,  G01N15/1425 ,  G01N15/1459 ,  G01N2015/1402 ,  G01N2015/149

Abstract: Aspects of the present disclosure include methods for adjusting sensitivity of a photodiode in a light detection system. Methods according to certain embodiments include determining a background data signal from a photodetector at a plurality of detector gains, irradiating the photodetector with a light source at a plurality of different light intensities, generating data signals from the photodetector for the plurality of light intensities at each detector gain and adjusting the photodetector to the detector gain that corresponds to the lowest light irradiation intensity that generates a data signal resolvable from the background data signal. Systems (e.g., particle analyzers) having a light source and a light detection system that includes a photodetector for practicing the subject methods are also described. Non-transitory computer readable storage medium are also provided.

公开(公告)号：US11781963B2

公开(公告)日：2023-10-10

申请号：US17955069

申请日：2022-09-28

Applicant: BECTON, DICKINSON AND COMPANY

Inventor： Fedor Ilkov ,  Shreyas Bhaban

IPC: G01N15/10 ,  G01J1/44

CPC classification number: G01N15/1012 ,  G01J2001/444 ,  G01N2015/1006

Abstract: Aspects of the present disclosure include methods for determining a parameter of a photodetector (e.g., a photodetector in a particle analyzer). Methods according to certain embodiments include irradiating a photodetector positioned in a particle analyzer with a light source (e.g., a continuous wave light source) at a first intensity for a first predetermined time interval, irradiating the photodetector with the light source at a second intensity for a second predetermined time interval, integrating data signals from the photodetector over a period of time that includes the first predetermined interval and the second predetermined interval and determining one or more parameters of the photodetector based on the integrated data signals. Systems (e.g., particle analyzers) having light source and a photodetector for practicing the subject methods are also described. Non-transitory computer readable storage medium having instructions stored thereon for determining a parameter of a photodetector according to the subject methods are also provided.

公开(公告)号：US20230091403A1

公开(公告)日：2023-03-23

申请号：US17955069

申请日：2022-09-28

Applicant: BECTON, DICKINSON AND COMPANY

Inventor： Fedor Ilkov ,  Shreyas Bhaban

IPC: G01N15/10

Abstract: Aspects of the present disclosure include methods for determining a parameter of a photodetector (e.g., a photodetector in a particle analyzer). Methods according to certain embodiments include irradiating a photodetector positioned in a particle analyzer with a light source (e.g., a continuous wave light source) at a first intensity for a first predetermined time interval, irradiating the photodetector with the light source at a second intensity for a second predetermined time interval, integrating data signals from the photodetector over a period of time that includes the first predetermined interval and the second predetermined interval and determining one or more parameters of the photodetector based on the integrated data signals. Systems (e.g., particle analyzers) having light source and a photodetector for practicing the subject methods are also described. Non-transitory computer readable storage medium having instructions stored thereon for determining a parameter of a photodetector according to the subject methods are also provided.