公开(公告)号：US20230339882A1

公开(公告)日：2023-10-26

申请号：US18016144

申请日：2021-07-22

申请人： Betta Pharmaceuticals Co., Ltd.

发明人： Hao WU ,  Wenmao WU ,  Ling LI ,  Zhan ZHANG ,  Feng WANG ,  Ding YUAN ,  Yunfei WU ,  Qiang CHEN ,  Han HAN ,  Jing GUO ,  Hong LAN ,  Lieming DING ,  Jiabing WANG

IPC分类号： C07D401/04 ,  A61P35/00 ,  C07D401/14 ,  C07D413/14 ,  C07D405/14 ,  C07D491/107 ,  C07D471/10 ,  C07D513/10 ,  C07D498/10

CPC分类号： C07D401/04 ,  A61P35/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/10 ,  C07D491/107 ,  C07D498/10 ,  C07D513/10

摘要： A compound (as represented by formula I) serving as an Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) inhibitor, as well as a pharmaceutical composition thereof, a preparation method therefor, and a use in treating an SHP2 mediation diseases. The compounds of formula I exerts an effect by means of participating in the regulation of multiple processes such as cell proliferation, apoptosis, migration, and angiogenesis.

公开(公告)号：US20230391779A1

公开(公告)日：2023-12-07

申请号：US18021784

申请日：2021-08-17

申请人： Betta Pharmaceuticals Co., Ltd.

发明人： Xiaofeng XU ,  Jinheng GAO ,  Hongfei RONG ,  Xizhen SONG ,  Jie CHEN ,  Xiangyong LIU ,  Hongling SHEN ,  Jing GUO ,  Dan YAN ,  Hong LAN ,  Lieming DING ,  Jiabing WANG

IPC分类号： C07D487/04 ,  C07D403/04 ,  C07D471/04 ,  C07D403/06 ,  C07D231/56 ,  C07D401/14 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14 ,  C07D405/14 ,  C07D493/04 ,  C07C237/20 ,  C07D205/04 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61P35/00 ,  C07D471/04 ,  C07D403/06 ,  C07D231/56 ,  C07D401/14 ,  C07D401/04 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14 ,  C07D405/14 ,  C07D493/04 ,  C07C237/20 ,  C07D205/04 ,  C07D403/04

摘要： The present invention relates to compounds of Formula (I), pharmaceutical compositions comprising such compounds and use thereof. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer.

公开(公告)号：US20230219890A1

公开(公告)日：2023-07-13

申请号：US18009362

申请日：2021-06-10

申请人： Betta Pharmaceuticals Co.,Ltd

发明人： Rongwen YANG ,  Yun SUN ,  Jian ZHANG ,  Xiangkai LIU ,  Pingping WANG ,  Xuegang YI ,  Teng MA ,  Chuanlong HUANG ,  Hong LAN ,  Lieming DING ,  Jiabing WANG

IPC分类号： C07D209/30 ,  C07D209/10 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D405/04 ,  C07D417/04 ,  C07D209/08 ,  C07D471/04 ,  C07D498/04 ,  C07D487/04

CPC分类号： C07D209/30 ,  C07D209/10 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D405/04 ,  C07D417/04 ,  C07D209/08 ,  C07D471/04 ,  C07D498/04 ,  C07D487/04

摘要： The present invention relates to a compound as represented by formula (I). The present invention also provides compositions and formulations containing such compounds, and methods for using and preparing such compounds.

公开(公告)号：US20230321100A1

公开(公告)日：2023-10-12

申请号：US18044049

申请日：2021-09-06

申请人： BETTA PHARMACEUTICALS CO., LTD

发明人： Hao WU ,  Xiaofeng YANG ,  Qisheng LIU ,  Han HAN ,  Jinhua LI ,  Yang LI ,  Feng JIANG ,  Cuiwen KUANG ,  Hongfeng XIA ,  Hongbo ZHANG ,  Hong LAN ,  Jiabing WANG ,  Lieming DING

IPC分类号： A61K31/513 ,  A61K39/395 ,  C07D403/04 ,  C07D401/14 ,  C07D403/14

CPC分类号： A61K31/513 ,  A61K39/3955 ,  C07D403/04 ,  C07D401/14 ,  C07D403/14

摘要： The present invention relates to a novel compound, which has cancer therapeutic activity. The present invention also relates to a preparation method for the compound and a pharmaceutical composition comprising the compound.

公开(公告)号：US20230219956A1

公开(公告)日：2023-07-13

申请号：US17605268

申请日：2020-04-20

申请人： BETTA PHARMACEUTICALS CO.,LTD

发明人： Hao WU ,  Yuan LU ,  Jun YU ,  Xiao ZHOU ,  Boyan LI ,  Jiangqi HE ,  Shuibiao FU ,  Rongwen YANG ,  Yabin LI ,  Chao WANG ,  Jiabing WANG ,  Hong LAN ,  Lieming DING

IPC分类号： C07D471/10 ,  C07D519/00 ,  C07D487/10 ,  C07D401/14 ,  C07D451/04 ,  A61P35/00

CPC分类号： C07D471/10 ,  C07D519/00 ,  C07D487/10 ,  C07D401/14 ,  C07D451/04 ,  A61P35/00

摘要： The present invention relates to a novel compound, which has cancer therapeutic activity. The present invention also relates to a preparation method for the compound and a pharmaceutical composition containing the compound. (I)

公开(公告)号：US20210261552A1

公开(公告)日：2021-08-26

申请号：US16973335

申请日：2019-06-06

申请人： Betta Pharmaceuticals Co., LTD

发明人： Hao WU ,  Wei GU ,  Xiaojing TANG ,  Wei WANG ,  Bo ZHAN ,  Dongjie FENG ,  Yongxin KE ,  Zhongyan CHEN ,  Yifei SHEN ,  Wenmao WU ,  Xintao ZHAO ,  Hong LAN ,  Jiabing WANG ,  Lieming DING

IPC分类号： C07D487/04 ,  A61P35/00 ,  C07D401/04 ,  C07D417/04 ,  C07D491/20 ,  C07D403/14 ,  C07D487/20 ,  C07D519/00 ,  C07D513/04

摘要： Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.