公开(公告)号：US20140024023A1

公开(公告)日：2014-01-23

申请号：US13949115

申请日：2013-07-23

Applicant: Bio-Rad Laboratories, Inc

Inventor： Thomas H. Cauley, III ,  Timothy Brackbill ,  Luc Bousse ,  Jon Petersen

IPC: G01N1/28

CPC classification number: G01N1/28 ,  B01F3/0807 ,  B01F13/0062 ,  B01L3/502784 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2400/0487 ,  B01L2400/084 ,  Y10T436/25

Abstract: System, including methods and apparatus, for forming droplets of an emulsion. The system may include a channel junction at which a stream of sample fluid is divided into droplets by a dividing flow of carrier fluid. The system also may include one or more features configured to position sample fluid for reduced contact between the sample fluid and one or more surface regions of the channel junction, which may improve the consistency of droplet formation. In exemplary embodiments, sample fluid may be positioned by a step member produced by an increase in channel depth, and/or by directing flow of carrier fluid to form a barrier layer between sample fluid and a wall region, such as a ceiling region or floor region, of a channel network.

Abstract translation: 用于形成乳液液滴的系统，包括方法和装置。 该系统可以包括通道结，在该通道连接处，样品流体流通过载体流体的分流被分成液滴。 该系统还可以包括被配置成定位样品流体以减少样品流体和通道结的一个或多个表面区域之间的接触的一个或多个特征，这可以改善液滴形成的一致性。 在示例性实施例中，样品流体可以由通过增加通道深度产生的台阶构件定位，和/或通过引导载体流体的流动来形成样品流体和壁区域之间的阻挡层，例如天花板区域或地板 区域，通道网络。

公开(公告)号：US20130269452A1

公开(公告)日：2013-10-17

申请号：US13863231

申请日：2013-04-15

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： Thomas H. Cauley III ,  Luc Bousse ,  Jon Petersen ,  Kevin D. Ness ,  Steven Romine

IPC: G01N1/00 ,  B32B38/00

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/027 ,  B01L2200/0673 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/086 ,  B01L2400/088 ,  B32B38/0012 ,  G01N1/00 ,  Y10T156/10 ,  Y10T156/1002

Abstract: Sample holding system, including methods and apparatus, including a holder defining a well having a wicking promoter that encourages flow of a sample to the bottom of the well. Methods of making and using the holder are also disclosed.

Abstract translation: 样品保持系统，包括方法和装置，包括限定具有促进样品流到井的底部的芯吸促进剂的阱的保持器。 还公开了制造和使用保持器的方法。