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Patent Agency Ranking
公开(公告)号：US20150246063A1
公开(公告)日：2015-09-03
申请号：US14417353
申请日：2013-07-26
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: A61K31/662 , A61K31/196 , A61K45/06 , C07D211/62 , A61K31/445 , C07D401/04 , A61K31/454 , C07D265/30 , A61K31/5375 , C07D215/20 , A61K31/47 , C07F9/38 , C07D213/80 , A61K31/435 , C07D223/06 , A61K31/55 , C07D205/04 , A61K31/397 , C07C229/48
CPC classification number: A61K31/662 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C229/46 , C07C229/48 , C07C233/47 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/26 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07D213/79 , C07D213/80 , C07D215/20 , C07D223/06 , C07D265/30 , C07D401/04 , C07D401/06 , C07F9/38 , C07F9/3808
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可调节自分泌素（ATX）的活性。
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公开(公告)号：US20150210647A1
公开(公告)日：2015-07-30
申请号：US14417300
申请日：2013-07-26
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: C07D223/06 , A61K31/5375 , C07D221/22 , A61K31/439 , C07D209/52 , A61K31/46 , C07D211/62 , A61K31/445 , C07D211/34 , C07C229/48 , A61K31/196 , C07C217/22 , A61K31/136 , A61K31/55 , A61K45/06 , C07D295/096
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
Abstract translation: 公开了式（I）的双环芳基化合物，其可以调节自分泌素（ATX）酶的活性。 本发明还涉及作为ATX抑制剂的化合物，以及制备和使用这些化合物治疗由于损伤或疾病引起的脱髓鞘以及治疗增殖性疾病如癌症的方法。
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公开(公告)号：US20150203515A1
公开(公告)日：2015-07-23
申请号：US14417293
申请日：2013-07-26
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur Taveras , Zhili Xin , Lei Zhang
IPC: C07F7/08 , A61K31/196 , C07D215/20 , A61K31/47 , C07D401/04 , A61K31/4545 , A61K31/506 , A61K31/495 , C07D213/74 , A61K31/496 , A61K31/551 , C07D205/04 , A61K31/397 , C07D401/06 , A61K31/695 , A61K45/06 , C07C211/38
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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公开(公告)号：US20150203493A1
公开(公告)日：2015-07-23
申请号：US14420020
申请日：2013-08-05
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D471/08 , C07C211/38 , A61K31/196 , C07D205/04 , A61K31/397 , C07D209/52 , A61K31/403 , C07D207/08 , A61K31/40 , C07D223/06 , A61K31/55 , C07D211/62 , A61K31/445 , A61K45/06 , A61K31/439
CPC classification number: C07D471/08 , A61K31/122 , A61K31/196 , A61K31/397 , A61K31/40 , A61K31/403 , A61K31/439 , A61K31/44 , A61K31/445 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C211/38 , C07C229/48 , C07C2601/04 , C07C2601/14 , C07D205/04 , C07D207/08 , C07D207/16 , C07D209/52 , C07D211/62 , C07D223/06 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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5.发明申请公开(公告)号：US20150183741A1
公开(公告)日：2015-07-02
申请号：US14420025
申请日：2013-08-05
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D211/62 , A61K45/06 , C07D451/14 , A61K31/439 , C07D211/34 , A61K31/46 , A61K31/196 , C07C229/14 , A61K31/198 , A61K31/197 , C07D451/02 , A61K31/445 , C07C229/48
CPC classification number: C07D211/62 , A61K31/122 , A61K31/192 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/439 , A61K31/445 , A61K31/45 , A61K31/46 , A61K45/06 , C07C229/14 , C07C229/48 , C07C2601/14 , C07D211/34 , C07D211/60 , C07D451/02 , C07D451/14 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。
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