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公开(公告)号：US20150299123A1
公开(公告)日：2015-10-22
申请号：US14443944
申请日：2013-11-20
Applicant: BIOGEN IDEC MA INC.
Inventor： Hairuo Peng , Zhili Xin , Lihong Sun , Timothy Chan , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: C07D211/62 , C07C229/14 , A61K31/197 , C07D207/16 , A61K31/40 , C07C229/48 , A61K31/196 , C07D205/04 , A61K31/397 , C07D211/34 , C07C229/50 , C07D211/46 , C07D401/10 , A61K31/4545 , C07D237/14 , A61K31/50 , C07D239/34 , A61K31/505 , C07D417/04 , A61K31/427 , A61K45/06 , A61K31/445
CPC classification number: C07D211/62 , A61K31/196 , A61K31/197 , A61K31/397 , A61K31/40 , A61K31/427 , A61K31/445 , A61K31/4545 , A61K31/50 , A61K31/505 , A61K45/06 , C07B2200/07 , C07C229/14 , C07C229/48 , C07C229/50 , C07C2601/14 , C07C2602/44 , C07D205/04 , C07D207/16 , C07D209/44 , C07D211/34 , C07D211/46 , C07D213/38 , C07D213/65 , C07D215/14 , C07D237/14 , C07D239/34 , C07D249/06 , C07D277/28 , C07D401/04 , C07D401/10 , C07D417/04 , C07D417/06 , C07D487/04
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物及其药学上可接受的盐可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。
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公开(公告)号：US20150274663A1
公开(公告)日：2015-10-01
申请号：US14443912
申请日：2013-11-20
Applicant: BIOGEN IDEC MA INC.
Inventor： Hairuo Peng , Edward Yin-Shiang Lin , Jianhua Chao , Zhili Xin , Bin Ma , Kevin Guckian , Timothy Chan , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: C07D211/22 , C07D401/12 , A61K31/4545 , C07D295/15 , A61K45/06 , C07D403/04 , A61K31/501 , A61K31/506 , C07D401/04 , A61K31/451 , A61K31/495
CPC classification number: C07D211/22 , A61K31/451 , A61K31/4545 , A61K31/495 , A61K31/501 , A61K31/506 , A61K45/06 , C07D207/08 , C07D211/56 , C07D211/62 , C07D211/70 , C07D213/74 , C07D237/22 , C07D239/47 , C07D295/15 , C07D295/155 , C07D401/04 , C07D401/12 , C07D403/04
Abstract: Compounds of formula (I) wherein: X is —O—, —S(O)r—, —CH2—, or —NR—, wherein r is 0, 1, or 2; X1, X2, and X5 are each independently CR7 or N; one of X3 or X4 is C and is attached by a single bond to -L-, and the other is CR7 or N, provided that no more than three of X1, X2, X3, X or X5 are N; Ring A is monocyclic C5-6scycloalkyl or a 5- to 6-membered monocyclic heterocyclyl comprising from 1 to 5 heteroatoms independently selected from N, S, or O; wherein Ring A is further optionally substituted with from 1 to 3 R4; provided that Ring A is not morpholinyl, thiomorpholinyl or tetrahydro-2H-pyranyl; L is a bond, —O—, —NR—, —S(O)n—, —CH2—, or —C(O)—, wherein n is 0, 1, or 2; 1 2 L1 is an C1-8alkylene, C3-scycloalkylene, —CH2-L2-, or a 3- to 8-membered heterocyclylene comprising 1 to 5; R1 is C6-20alkyl or a monocyclic C3-8cycloalkyl; wherein said C3-8cycloalkyl is substituted with at least one R6 and may be optionally substituted with from 1 to 5 additional R6 substituents, wherein R6 for each occurrence is independently selected; and R2 is —C(O)OR3, —C(O)N(R3)—S(O)2R3, —S(O)2OR3, —C(O)NHC(O)R3, —Si(O)OH, —B(OH)2, —N(R3)S(O)2R3, —S(O)2N(R3)2, —O—P(O)(OR3)2, or —P(O)(OR3)2, —CN, —S(O)2NHC(O)R3, —C(O)NHS(O)2R3, —C(O)NHOH, —C(O)NHCN, —CH(CF3)OH, —C(CF3)2OH, or a selected heteroaryl or heterocyclyl; and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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公开(公告)号：US20150203515A1
公开(公告)日：2015-07-23
申请号：US14417293
申请日：2013-07-26
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur Taveras , Zhili Xin , Lei Zhang
IPC: C07F7/08 , A61K31/196 , C07D215/20 , A61K31/47 , C07D401/04 , A61K31/4545 , A61K31/506 , A61K31/495 , C07D213/74 , A61K31/496 , A61K31/551 , C07D205/04 , A61K31/397 , C07D401/06 , A61K31/695 , A61K45/06 , C07C211/38
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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公开(公告)号：US20150203493A1
公开(公告)日：2015-07-23
申请号：US14420020
申请日：2013-08-05
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D471/08 , C07C211/38 , A61K31/196 , C07D205/04 , A61K31/397 , C07D209/52 , A61K31/403 , C07D207/08 , A61K31/40 , C07D223/06 , A61K31/55 , C07D211/62 , A61K31/445 , A61K45/06 , A61K31/439
CPC classification number: C07D471/08 , A61K31/122 , A61K31/196 , A61K31/397 , A61K31/40 , A61K31/403 , A61K31/439 , A61K31/44 , A61K31/445 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C211/38 , C07C229/48 , C07C2601/04 , C07C2601/14 , C07D205/04 , C07D207/08 , C07D207/16 , C07D209/52 , C07D211/62 , C07D223/06 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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5.发明申请公开(公告)号：US20150183741A1
公开(公告)日：2015-07-02
申请号：US14420025
申请日：2013-08-05
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Lihong Sun , Zhili Xin , Lei Zhang
IPC: C07D211/62 , A61K45/06 , C07D451/14 , A61K31/439 , C07D211/34 , A61K31/46 , A61K31/196 , C07C229/14 , A61K31/198 , A61K31/197 , C07D451/02 , A61K31/445 , C07C229/48
CPC classification number: C07D211/62 , A61K31/122 , A61K31/192 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/439 , A61K31/445 , A61K31/45 , A61K31/46 , A61K45/06 , C07C229/14 , C07C229/48 , C07C2601/14 , C07D211/34 , C07D211/60 , C07D451/02 , C07D451/14 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。
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Patent Agency Ranking
公开(公告)号：US20140309212A1
公开(公告)日：2014-10-16
申请号：US14316710
申请日：2014-06-26
Applicant: Biogen Idec MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D487/04 , C07D401/04 , C07D417/14 , C07D473/34
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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公开(公告)号：US20150246063A1
公开(公告)日：2015-09-03
申请号：US14417353
申请日：2013-07-26
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: A61K31/662 , A61K31/196 , A61K45/06 , C07D211/62 , A61K31/445 , C07D401/04 , A61K31/454 , C07D265/30 , A61K31/5375 , C07D215/20 , A61K31/47 , C07F9/38 , C07D213/80 , A61K31/435 , C07D223/06 , A61K31/55 , C07D205/04 , A61K31/397 , C07C229/48
CPC classification number: A61K31/662 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C229/46 , C07C229/48 , C07C233/47 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/26 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07D213/79 , C07D213/80 , C07D215/20 , C07D223/06 , C07D265/30 , C07D401/04 , C07D401/06 , C07F9/38 , C07F9/3808
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可调节自分泌素（ATX）的活性。
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公开(公告)号：US20150210647A1
公开(公告)日：2015-07-30
申请号：US14417300
申请日：2013-07-26
Applicant: BIOGEN IDEC MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: C07D223/06 , A61K31/5375 , C07D221/22 , A61K31/439 , C07D209/52 , A61K31/46 , C07D211/62 , A61K31/445 , C07D211/34 , C07C229/48 , A61K31/196 , C07C217/22 , A61K31/136 , A61K31/55 , A61K45/06 , C07D295/096
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
Abstract translation: 公开了式（I）的双环芳基化合物，其可以调节自分泌素（ATX）酶的活性。 本发明还涉及作为ATX抑制剂的化合物，以及制备和使用这些化合物治疗由于损伤或疾病引起的脱髓鞘以及治疗增殖性疾病如癌症的方法。
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公开(公告)号：US20150232492A1
公开(公告)日：2015-08-20
申请号：US14620700
申请日：2015-02-12
Applicant: BIOGEN IDEC MA INC.
Inventor： Richard D. Caldwell , Kevin Guckian , Gnanasambandam Kumaravel , Wen-Cherng Lee , Edward Yin-Shiang Lin , Xiaogao Liu , Bin Ma , Daniel M. Scott , Zhan Shi , Jermaine Thomas , Arthur G. Taveras , Guo Zhu Zheng
IPC: C07F9/6512 , C07C229/36 , C07D239/80 , C07D263/24 , C07D215/20 , C07F9/60 , C07C233/47 , C07C217/58
CPC classification number: C07F9/6512 , C07C217/58 , C07C217/74 , C07C229/36 , C07C233/47 , C07C2602/10 , C07D215/06 , C07D215/20 , C07D215/227 , C07D233/32 , C07D239/74 , C07D239/80 , C07D263/24 , C07D277/64 , C07D401/04 , C07F9/091 , C07F9/60 , C07F9/65744
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
Abstract translation: 提供了在一种或多种S1P受体上具有激动剂活性的化合物。 化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。
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公开(公告)号：US09249146B2
公开(公告)日：2016-02-02
申请号：US14316710
申请日：2014-06-26
Applicant: Biogen Idec MA Inc. , Sunesis Pharmaceuticals, Inc.
Inventor： Minna Bui , Patrick Conlon , Julio H. Cuervo , Daniel A. Erlanson , Junfa Fan , Bing Guan , Brian T. Hopkins , Tracy J. Jenkins , Gnanasambandam Kumaravel , Alexey A. Lugovskoy , Doug Marcotte , Noel Powell , Daniel Scott , Laura Silvian , Art Taveras , Deping Wang , Min Zhong
IPC: C07D401/04 , A61K31/519 , C07D487/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34
CPC classification number: C07D487/14 , A61K31/519 , C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/34 , C07D487/04
Abstract: The present invention provides compounds useful as inhibitors of Btk, compositions thereof, and methods of using the same.
Abstract translation: 本发明提供了可用作Btk抑制剂的化合物，其组合物及其使用方法。
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