专利检索 ap:("BIOGEN MA INC.") AND inv:"Yannick Fillon" 第 1 页

1.

发明公开
OLIGONUCLEOTIDES, REAGENTS, AND PREPARATION THEREOF 审中-公开

公开(公告)号：US20230406878A1

公开(公告)日：2023-12-21

申请号：US18036459

申请日：2021-11-10

申请人： BIOGEN MA INC.

发明人： Wuming Yan , Xuan Zhou , Xianglin Shi , Firoz Antia , William F. Kiesman , Yannick Fillon

IPC分类号： C07H21/02 , C07F7/18 , C07D249/06 , C07D295/192 , C07H23/00 , C07H21/04

CPC分类号： C07H21/02 , C07F7/1804 , C07D249/06 , C07D295/192 , C07H23/00 , C07H21/04

摘要： The present disclosure describes novel reagents and processes for preparing oligonucleotides, which have two or more nucleotides. In one embodiment, the reagent is represented by Formula I′ or B.

2.

发明申请
CONVERGENT LIQUID PHASE SYNTHESES OF OLIGONUCLEOTIDES 有权

公开(公告)号：US20220348602A1

公开(公告)日：2022-11-03

申请号：US17608802

申请日：2020-05-08

申请人： BIOGEN MA Inc. , AJINOMOTO CO., Inc.

发明人： Xianglin Shi , William F. Kiesman , Firoz Antia , Yannick Fillon , Xuan Zhou , Wuming Yan , Hong Jiang , Hien Nguyen , Robert S. Gronke , Taisuke Ichimaru , Takuya Hamagaki , Daisuke Takahashi

IPC分类号： C07H1/02 , C07H21/02

摘要： The present disclosure describes a convergent liquid phase process for manufacturing oligonucleotides by coupling two or more oligonucleotide fragments, each of which have two or more nucleotides. Also provided by the present disclosure are reaction steps involved the convergent liquid phase process.

3.

发明授权
Synthesis of thiolated oligonucleotides without a capping step 有权

公开(公告)号：US11142545B2

公开(公告)日：2021-10-12

申请号：US16312819

申请日：2017-06-22

申请人： BIOGEN MA INC.

发明人： Xianglin Shi , Jimin Yang , William F. Kiesman , Yannick Fillon

IPC分类号： C07H21/04 , C07H1/00 , C07H21/02 , C07H21/00

摘要： The invention herein describes a solid-phase synthetic method for preparing thiolated oligonucleotides without needing a capping step. The methods of the invention comprises repetition of a three-reaction per cycle, namely detritylation, coupling and sulfurization, without a capping step. In some embodiments, the synthetic methods of the present invention can be used for preparing an anti-sense oligonucleotide.

4.

发明申请
SYNTHESIS OF THIOLATED OLIGONUCLEOTIDES WITHOUT A CAPPING STEP 审中-公开

公开(公告)号：US20190161513A1

公开(公告)日：2019-05-30

申请号：US16312819

申请日：2017-06-22

申请人： BIOGEN MA INC.

发明人： Xianglin Shi , Jimin Yang , William F. Kiesman , Yannick Fillon

IPC分类号： C07H21/04 , C07H21/02 , C07H1/00

摘要： The invention herein describes a synthetic method for preparing thiolated oligonucleotides without needing a capping step, as the sulfurization agent caps the unreacted 5′-OH groups.