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    DOUBLE-STRANDED OLIGONUCLEOTIDE TARGETING DKK1 GENE, CONSTRUCT INCLUDING SAME, AND HAIR LOSS PREVENTION OR HAIR GROWTH COMPOSITION CONTAINING SAME
    2.
    发明申请
    DOUBLE-STRANDED OLIGONUCLEOTIDE TARGETING DKK1 GENE, CONSTRUCT INCLUDING SAME, AND HAIR LOSS PREVENTION OR HAIR GROWTH COMPOSITION CONTAINING SAME 有权

    公开(公告)号：US20220088051A1

    公开(公告)日：2022-03-24

    申请号：US17423372

    申请日：2020-01-15

    申请人： BIONEER CORPORATION

    发明人： Han-Oh PARK ,  Sung II YUN ,  Sang-Jin BYUN ,  Pyoung Oh YOON ,  Sang-Kyu LEE ,  Tae-Rim KIM ,  Young-Ho KO ,  Seung-Seob SON ,  Eun-Ah GOH ,  Hyung-Jin KIM

    IPC分类号： A61K31/713 ,  A61P17/14

    摘要： The present invention pertains to: a double-stranded oligonucleotide construct having a structure in which a hydrophilic substance and a hydrophobic substance are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a DKK1-specific double-stranded oligonucleotide to efficiently deliver the double-stranded oligonucleotide into cells; a nanoparticle capable of being produced through self-assembly of the double-stranded oligonucleotide construct through a hydrophobic interaction in an aqueous solution; and a hair-loss-preventing and hair-growth-promoting composition containing the double-stranded oligonucleotide construct or the nanoparticle. A double-stranded oligonucleotide construct including a DKK1-specific double-stranded oligonucleotide, a nanoparticle, and a hair loss prevention or hair growth composition containing the double-stranded oligonucleotide construct or the nanoparticle as an active ingredient according to the present invention very efficiently suppress the expression of DKK1 without side effects and are remarkably effective for preventing hair loss and promoting hair growth, and can thus be very usefully used for a composition for preventing hair loss and promoting hair growth.

    NOVEL DOUBLE-STRANDED OLIGO RNA AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING OR TREATING FIBROSIS OR RESPIRATORY DISEASES
    3.
    发明申请
    NOVEL DOUBLE-STRANDED OLIGO RNA AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR PREVENTING OR TREATING FIBROSIS OR RESPIRATORY DISEASES 审中-公开

    公开(公告)号：US20170130231A1

    公开(公告)日：2017-05-11

    申请号：US15301713

    申请日：2015-04-06

    申请人： Bioneer Corporation

    发明人： Jeiwook CHAE ,  Pyoung Oh YOON ,  Boram HAN ,  Mi Na KIM ,  Youngho KO ,  Han Oh PARK

    IPC分类号： C12N15/113

    CPC分类号： C12N15/1136 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32

    摘要： The present invention relates to a novel siRNA, and a high-efficiency double-stranded oligo RNA structure containing the same, and a nanoparticle containing the high-efficiency double-stranded oligo RNA structure. The double-stranded oligo RNA structure has a structure in which a hydrophilic material and a hydrophobic material are conjugated to both ends of a double-stranded oligo RNA (siRNA) via a simple covalent bond or linker-mediated covalent bond in order to be efficiently delivered into cells, and may be converted into a nanoparticle form in an aqueous solution by hydrophobic interactions of double-stranded oligo RNA structures. It is preferable that the siRNA contained in the double-stranded oligo RNA structure is an siRNA specific for fibrosis or respiratory disease-related gene, particularly, amphiregulin or stratifin.In addition, the present invention relates to a pharmaceutical composition for preventing or treating fibrosis or respiratory diseases, containing an siRNA, a high-efficiency double-stranded oligo RNA structure containing the siRNA, or a nanoparticle containing the high-efficiency double-stranded oligo RNA structure, as an active ingredient.In addition, the present invention relates to a method of preventing or treating fibrosis or respiratory diseases, including administering the pharmaceutical composition for preventing or treating fibrosis or respiratory diseases to a subject in need thereof.