公开(公告)号：US20230332154A1

公开(公告)日：2023-10-19

申请号：US18330853

申请日：2023-06-07

Applicant: Bioneer Corporation

Inventor： Tae-Rim KIM ,  Pyoung Oh YOON ,  Youngho KO ,  Seon Joo BAE ,  Han-Oh PARK ,  Seung Seob SON ,  Jun-Hong PARK ,  Sung-Il YUN

IPC: C12N15/113 ,  A61P11/00 ,  A61K9/19 ,  A61K31/713

CPC classification number: C12N15/1136 ,  A61P11/00 ,  A61K9/19 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/314 ,  C12N2310/322 ,  C12N2310/351 ,  C12N2310/3515

Abstract: The present invention relates to a double-stranded oligonucleotide which can highly specifically and efficiently inhibit an amphiregulin expression and, preferably, a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA hybrid, a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide, nanoparticles comprising the double-stranded oligonucleotide structure, and a fibrosis or respiratory disease preventive or therapeutic use thereof.

公开(公告)号：US20220088051A1

公开(公告)日：2022-03-24

申请号：US17423372

申请日：2020-01-15

Applicant: BIONEER CORPORATION

Inventor： Han-Oh PARK ,  Sung II YUN ,  Sang-Jin BYUN ,  Pyoung Oh YOON ,  Sang-Kyu LEE ,  Tae-Rim KIM ,  Young-Ho KO ,  Seung-Seob SON ,  Eun-Ah GOH ,  Hyung-Jin KIM

IPC: A61K31/713 ,  A61P17/14

Abstract: The present invention pertains to: a double-stranded oligonucleotide construct having a structure in which a hydrophilic substance and a hydrophobic substance are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a DKK1-specific double-stranded oligonucleotide to efficiently deliver the double-stranded oligonucleotide into cells; a nanoparticle capable of being produced through self-assembly of the double-stranded oligonucleotide construct through a hydrophobic interaction in an aqueous solution; and a hair-loss-preventing and hair-growth-promoting composition containing the double-stranded oligonucleotide construct or the nanoparticle. A double-stranded oligonucleotide construct including a DKK1-specific double-stranded oligonucleotide, a nanoparticle, and a hair loss prevention or hair growth composition containing the double-stranded oligonucleotide construct or the nanoparticle as an active ingredient according to the present invention very efficiently suppress the expression of DKK1 without side effects and are remarkably effective for preventing hair loss and promoting hair growth, and can thus be very usefully used for a composition for preventing hair loss and promoting hair growth.

公开(公告)号：US20230203494A1

公开(公告)日：2023-06-29

申请号：US18067363

申请日：2022-12-16

Applicant: BIONEER CORPORATION

Inventor： Tae-Rim KIM ,  Pyoung Oh YOON ,  Youngho KO ,  Seon Joo BAE ,  Han-Oh PARK ,  Seung Seob SON ,  Jun-Hong PARK ,  Sung-II YUN

IPC: C12N15/113 ,  A61P11/00 ,  A61K9/19 ,  A61K31/713

CPC classification number: C12N15/1136 ,  A61P11/00 ,  A61K9/19 ,  A61K31/713 ,  C12N2310/14 ,  C12N2310/314 ,  C12N2310/322 ,  C12N2310/351 ,  C12N2310/3515

Abstract: The present invention relates to a double-stranded oligonucleotide which can highly specifically and efficiently inhibit an amphiregulin expression and, preferably, a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA hybrid, a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide, nanoparticles comprising the double-stranded oligonucleotide structure, and a fibrosis or respiratory disease preventive or therapeutic use thereof.

公开(公告)号：US20230042493A1

公开(公告)日：2023-02-09

申请号：US17778836

申请日：2020-10-29

Applicant: BIONEER CORPORATION

Inventor： Han-Oh PARK ,  Tae-Rim KIM ,  Young-Ho KO ,  Sung ll YUN ,  Jun Hong PARK

IPC: C12N15/113

Abstract: The present invention relates to a double-stranded oligonucleotide capable of inhibiting CTGF expression with a very specific and high efficiency, a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide, and a use thereof in preventing or treating of fibrotic or respiratory diseases.

公开(公告)号：US20210189398A1

公开(公告)日：2021-06-24

申请号：US17057852

申请日：2019-05-22

Applicant: BIONEER CORPORATION

Inventor： Tae-Rim KIM ,  Pyoung Oh YOON ,  Youngho KO ,  Seon Joo BAE ,  Han-Oh PARK ,  Seung Seob SON ,  Jun-Hong PARK ,  Sung-II YUN

IPC: C12N15/113 ,  A61K9/19 ,  A61P11/00

Abstract: The present invention relates to a double-stranded oligonucleotide which can highly specifically and efficiently inhibit an amphiregulin expression and, preferably, a double-stranded oligonucleotide comprising a sequence in the form of RNA/RNA, DNA/DNA or DNA/RNA hybrid, a double-stranded oligonucleotide structure comprising the double-stranded oligonucleotide, nanoparticles comprising the double-stranded oligonucleotide structure, and a fibrosis or respiratory disease preventive or therapeutic use thereof.