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Patent Agency Ranking
公开(公告)号：US20170136129A1
公开(公告)日：2017-05-18
申请号：US15323599
申请日：2014-07-04
Applicant: BioNTech AG
Inventor： Steve Pascolo
IPC: A61K47/00 , A61K39/39 , A61K48/00 , A61K47/26 , C12N15/117
CPC classification number: C12N15/117 , A61K9/0019 , A61K39/39 , A61K47/26 , A61K47/6455 , A61K47/6931 , A61K48/0041 , A61K2039/55561 , C12N2310/17 , C12N2310/351 , C12N2320/32
Abstract: The present invention relates to stable low-salt aqueous formulations of particles comprising a polycation, preferably protamine, and RNA, which formulations are preferably isotonic, to pharmaceutical compositions or kits comprising such formulations and to their use in medicine. It further relates to methods for preparing the formulations of the invention and to methods for physically stabilizing particles comprising a polycation, preferably protamine, and RNA.
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公开(公告)号：US10980875B2
公开(公告)日：2021-04-20
申请号：US15763541
申请日：2016-10-20
Applicant: BIONTECH AG
Inventor： Steve Pascolo
Abstract: The present invention relates to particles comprising RNA, in which the RNA is associated with a cationic polymer or lipid or with both a cationic polymer and lipid, wherein the RNA comprises a cytotoxic nucleotide or cytotoxic nucleotide analog and/or the RNA is covalently attached to a cytotoxin, pharmaceutical compositions containing said particles and pharmaceutical uses of the particles and pharmaceutical compositions. The particles of the present invention are particularly useful as an immunostimulating medicament capable to block proliferation or induce death in dividing cells such as tumor cells.
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3.发明申请公开(公告)号：US20170151349A1
公开(公告)日：2017-06-01
申请号：US15309686
申请日：2014-05-19
Applicant: BioNTech AG
Inventor： Steve Pascolo
Abstract: The present invention relates to particles comprising protamine, RNA and at least one endosome destabilizing agent, to methods of their production and to pharmaceutical compositions or kits containing the particles. It further relates to particles comprising protamine and RNA for use in methods of treatment or prevention of diseases and to kits comprising such particles together with at least one endosome destabilizing agent.
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公开(公告)号：US10172960B2
公开(公告)日：2019-01-08
申请号：US15465078
申请日：2017-03-21
Applicant: BIONTECH AG
Inventor： Steve Pascolo
IPC: A61K48/00 , C12N15/11 , A61K9/16 , C07H21/02 , C07H21/04 , A61K47/64 , A61K31/7105 , A61K31/713 , A61K39/385 , A61K9/51 , A61K39/39 , A61K39/00
Abstract: The present invention relates to chimeric particles comprising single stranded RNA (ssRNA), double stranded RNA (dsRNA) and at least one cationic agent, a pharmaceutical composition containing said particles and to a method of producing the same. The particles of the present invention are particularly useful as an immunostimulating medicament with a superlative pattern of immunostimulation.
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公开(公告)号：US20170266301A1
公开(公告)日：2017-09-21
申请号：US15465078
申请日：2017-03-21
Applicant: BIONTECH AG
Inventor： Steve Pascolo
IPC: A61K31/7105 , A61K31/713 , A61K39/385 , A61K9/16 , A61K39/00
CPC classification number: A61K47/646 , A61K9/1658 , A61K9/51 , A61K9/5169 , A61K31/7105 , A61K31/713 , A61K39/385 , A61K39/39 , A61K48/00 , A61K2039/55555 , A61K2039/55561 , A61K2039/58 , A61K2039/62
Abstract: The present invention relates to chimeric particles comprising single stranded RNA (ssRNA), double stranded RNA (dsRNA) and at least one cationic agent, a pharmaceutical composition containing said particles and to a method of producing the same. The particles of the present invention are particularly useful as an immunostimulating medicament with a superlative pattern of immunostimulation.
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