公开(公告)号：US09636416B2

公开(公告)日：2017-05-02

申请号：US14530256

申请日：2014-10-31

Applicant: Bioverativ Therapeutics Inc.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitoni ,  Susan C. Low

IPC: C07K14/475 ,  A61K47/48 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  C12N9/96

CPC classification number: C07K14/755 ,  A61K38/00 ,  A61K47/60 ,  A61K47/642 ,  A61K47/68 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6835 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07K14/59 ,  C07K14/61 ,  C07K14/70503 ,  C07K14/745 ,  C07K16/00 ,  C07K2317/52 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/647 ,  C12N9/96 ,  C12Y304/21021 ,  C12Y304/21022

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US20200071385A1

公开(公告)日：2020-03-05

申请号：US16518642

申请日：2019-07-22

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K14/755 ,  A61K47/68 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  C07K14/565 ,  C12N9/96 ,  A61K47/60 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US11084866B2

公开(公告)日：2021-08-10

申请号：US15465319

申请日：2017-03-21

Applicant: Bioverativ Therapeutics Inc.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K19/00 ,  A61K39/00 ,  C07K14/755 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  A61K47/68 ,  C07K14/565 ,  C12N9/96 ,  A61K47/60 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64 ,  A61K38/00

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US11168125B2

公开(公告)日：2021-11-09

申请号：US16518642

申请日：2019-07-22

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K14/755 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  A61K47/68 ,  C07K14/565 ,  C12N9/96 ,  A61K47/60 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64 ,  A61K38/00

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US20170226189A1

公开(公告)日：2017-08-10

申请号：US15491742

申请日：2017-04-19

Applicant: Bioverativ Therapeutics Inc.

Inventor： Robert T. PETERS ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitoni ,  Susan C. Low

IPC: C07K14/755 ,  C07K14/61 ,  C07K14/56 ,  C12N9/96 ,  C07K14/59 ,  C07K14/565 ,  C12N9/64 ,  C07K14/705 ,  C07K14/505

CPC classification number: C07K14/755 ,  A61K38/00 ,  A61K47/60 ,  A61K47/642 ,  A61K47/68 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6835 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07K14/59 ,  C07K14/61 ,  C07K14/70503 ,  C07K14/745 ,  C07K16/00 ,  C07K2317/52 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/647 ,  C12N9/96 ,  C12Y304/21021 ,  C12Y304/21022

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US09725496B1

公开(公告)日：2017-08-08

申请号：US15491742

申请日：2017-04-19

Applicant: Bioverativ Therapeutics Inc.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K14/715 ,  C07K14/72 ,  C07K14/475 ,  C07K14/755 ,  C07K14/705 ,  C07K14/61 ,  C07K14/56 ,  C07K14/505 ,  C07K14/59 ,  C07K14/565 ,  A61K47/48 ,  C12N9/64 ,  C12N9/96 ,  A61K38/00

CPC classification number: C07K14/755 ,  A61K38/00 ,  A61K47/60 ,  A61K47/642 ,  A61K47/68 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6813 ,  A61K47/6835 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07K14/59 ,  C07K14/61 ,  C07K14/70503 ,  C07K14/745 ,  C07K16/00 ,  C07K2317/52 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/6437 ,  C12N9/644 ,  C12N9/647 ,  C12N9/96 ,  C12Y304/21021 ,  C12Y304/21022

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US10513551B2

公开(公告)日：2019-12-24

申请号：US15465319

申请日：2017-03-21

Applicant: Bioverativ Therapeutics Inc.

Inventor： Robert T. Peters ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K19/00 ,  A61K39/00 ,  C07K14/755 ,  C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  C12N9/96 ,  A61K47/60 ,  A61K47/68 ,  C07K14/59 ,  C07K14/61 ,  C07K14/705 ,  A61K47/64 ,  A61K38/00

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.

公开(公告)号：US20170266309A1

公开(公告)日：2017-09-21

申请号：US15465319

申请日：2017-03-21

Applicant: Bioverativ Therapeutics Inc.

Inventor： Robert T. PETERS ,  Adam R. Mezo ,  Daniel S. Rivera ,  Alan J. Bitonti ,  Susan C. Low

IPC: C07K14/475 ,  C07K14/505 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07K14/745 ,  C07K16/00 ,  C12N9/64 ,  C12N9/96

Abstract: The invention relates to a chimeric monomer-dimer hybrid protein wherein the protein comprises a first and a second polypeptide chain, the first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and the second polypeptide chain comprising at least a portion of an immunoglobulin constant region without the biologically active molecule of the first chain. The invention also relates to methods of using and methods of making the chimeric monomer-dimer hybrid protein of the invention.