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公开(公告)号：US3853466A
公开(公告)日：1974-12-10
申请号：US26292372
申请日：1972-06-14
发明人： RITTERSDORF W , RIECKMANN P , BERGER D , REY H
CPC分类号： G01N33/72 , Y10S436/903 , Y10T436/146666
摘要： Diagnostic agent for the detection of urobilinogens, optionally in the presence of bilirubin, in body fluids which agent comprises at least one stable benzene diazonium salt wherein the phenyl radical may be polysubstituted and contains in the o- or p-position at least one polyatomic electron donor group with at least one mesomeric electron pair, the sum of the Hammett sigma values for all the substituents not exceeding the value of +0.4.
摘要翻译： 用于在体液中检测泌尿生素（任选在胆红素存在下）的诊断剂，其中所述药物包含至少一种稳定的苯重氮盐，其中所述苯基可以是多取代的，并且在至少一个多原子电子 具有至少一个中间电子对的给体基团，所有取代基的哈米特σ值的总和不超过+0.4。
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公开(公告)号：US3853472A
公开(公告)日：1974-12-10
申请号：US37624873
申请日：1973-07-03
发明人： RITTERSDORF W , REY H , GUTHLEIN W , RIECKMANN P
CPC分类号： C12Q1/28 , C12Q1/04 , Y10S436/904
摘要： Test strips are provided for detecting even small amounts of blood or other peroxidatively active substances in body fluids; the strips comprising a carrier containing a hydroperoxide, a chromogen, and as an activator, a compound of the formula WHEREIN R1 is a hydrogen atom or a methyl radical and benzene and/or pyridine rings are fused on at least one of the positions indicated with c, (d,e), f and g, provided that two adjacent rings must not simultaneously each contain a cyclic nitrogen atom, and wherein the aromatic compounds (1), apart from the positions indicated by H and R1, can be substituted by lower alkyl radicals which together can also form a hydroaromatic ring.
摘要翻译： 提供测试条，用于检测体液中的少量血液或其他过氧化物质活性物质; 条带包含含有氢过氧化物，色原体和作为活化剂的载体，式WHEREIN R 1是氢原子或甲基，苯和/或吡啶环稠合在至少一个位置 c，（d，e），f和g，条件是两个相邻的环不能同时各自含有环状氮原子，并且其中芳族化合物（1）除了由H和R 1表示的位置可以被 低级烷基一起也可以形成一个水芳族环。
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公开(公告)号：US3850576A
公开(公告)日：1974-11-26
申请号：US31406772
申请日：1972-12-11
发明人： RIECKMANN P , RITTERSDORF W , BERGER D , REY H
CPC分类号： G01N33/72 , Y10S436/903 , Y10T436/146666
摘要： Urobilinogens, optionally in the presence of bilirubin, are detected with a novel diagnostic agent comprising A. AT LEAST ONE STABLE DIAZONIUM SALT CONTAINING A PHENYL-, PYRROLE, OR PYRAZOLE RING ANNELLATED WITH AN AROMATIC SYSTEM IN A MESOMERIZABLE AND STERICALLY UNHINDERED POSITION OR SUBSTITUTED DIRECTLY OR VIA A VINYLENE RADICAL WITH AN AROMATIC SYSTEM, OR B. A PYRIDINE OR PYRAZOLE DIAZONIUM SALT SUBSTITUTED IN A MESOMERIZABLE POSITION WITH AT LEAST ONE POLYATOMIC ELECTRON DONOR GROUP HAVING AT LEAST ONE MESOMERIZABLE ELECTRON PAIR WITH THE PROVISO THAT THE SUM OF THE Hammett sigma values for all the substituents, and hetero atoms does not exceed the value of +0.6.
摘要翻译： 任选地在胆红素存在下，用包含A的新型诊断剂检测无脊椎动物细胞。在具有可置换和无规定位置或直接取代的芳香系统中的至少一种稳定的二苯并三唑盐包含苯基，吡咯或吡唑环。 或通过具有芳族体系的乙烯基离子，或B.在具有至少一个可聚合电子对的至少一个可聚合电子对的可可位置中取代的吡啶或吡唑二盐，其具有Hammett sigma值的值 对于所有取代基，杂原子不超过+0.6的值。
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公开(公告)号：US3802842A
公开(公告)日：1974-04-09
申请号：US23231572
申请日：1972-03-02
发明人： LANGE H , RITTERSDORF W , REY H , RIECKMANN P
CPC分类号： C12Q1/28 , C12Q1/54 , G01N33/525 , Y10S435/805 , Y10T436/144444 , Y10T436/146666 , Y10T436/173076
摘要： Test strips for the detection of components in liquids, especially in body fluids, comprising a holder and at least one indicator layer containing detection reagents wherein one surface of the layer is attached to the holder and the other surface is covered with a fine meshwork.
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公开(公告)号：US3853476A
公开(公告)日：1974-12-10
申请号：US38224273
申请日：1973-07-24
发明人： RITTERSDORF W , REY H , RIECKMANN P , GUTHLEIN W , BERGER D
CPC分类号： G01N33/728 , Y10S436/903 , Y10T436/146666
摘要： WHEREIN R1 and R2 are individually selected from unsubstituted or substituted aliphatic, cycloaliphatic araliphatic or aromatic radicals, and contain not more than 18 carbon atoms each.
Bilirubin, particularly as contained in body fluids, is detected by contacting a test sample with a test composition comprising A. A DIAZONIUM SALT CAPABLE OF COUPLING WITH BILIRUBIN; B. AN ACID IN AN AMOUNT SUFFICIENT FOR THE COUPLING REACTION BETWEEN SAID SALT AND BILIRUBIN AND; C. A PHOSPHORIC ACID DIESTER OF THE FORMULA:摘要翻译： 通过使测试样品与包含A的测试组合物接触来检测体液中特别包含的胆红素。可与二氯联苯结合的二氮嗪盐; B.对于盐酸和胆红素之间的联合反应的量足够大; C.公式的磷酸乳剂：
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6.发明授权Diagnostic composition for the detection of peroxidatively active substances in body fluids 失效用于检测体液中过氧化物质活性物质的诊断组合物
公开(公告)号：US3853471A
公开(公告)日：1974-12-10
申请号：US37624973
申请日：1973-07-03
发明人： RITTERSDORF W , REY H , RIECKMANN P
CPC分类号： C12Q1/28 , Y10S436/904
摘要： Test strips are provided for detecting even small amounts of blood or other peroxidatively active substances in body fluids; the strips comprising a carrier containing a hydroperoxide, at least one chromogen and, as a stabilizer, at least one phosphoric or phosphonic acid amide of the formula WHEREIN R1 is a dimethylamino, alkoxy, aryloxy, alkyl, aryl or Nmorpholine radical; and R2 and R3, which may be the same or different, are dimethylamino or N-morpholine radicals.
摘要翻译： 提供测试条，用于检测体液中的少量血液或其他过氧化物质活性物质; 所述条带包含含有氢过氧化物的载体，至少一种色原体和作为稳定剂的至少一种式WHEREIN R 1的磷酸或膦酸酰胺是二甲基氨基，烷氧基，芳氧基，烷基，芳基或N-吗啉基; 并且可以相同或不同的R 2和R 3是二甲基氨基或N-吗啉基。
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7.发明授权
公开(公告)号：US3786140A
公开(公告)日：1974-01-15
申请号：US3786140D
申请日：1970-09-03
发明人： MEYER BERTENRATH J , KAFFARNIK H , BUSCH E , REY H , MICHAL G
CPC分类号： C12Q1/44 , C12Q1/34 , C12Q2334/40 , G01N2333/918
摘要： THERE ARE PROVIDED A DIAGNOSTIC COMPOSITION FOR THE DETERMINATION OF THE ACTIVITY OF PANCREATIC ENZYMES IN THE LIVING HUMAN BODY AND A METHOD FOR CARRYING OUT THIS EXAMINATION OF THE EXOCRINE PANCREAS FUNCTION.THE NEW DIAGNOSTIC COMPOSITION COMPRISES A MONOESTER OF FLUORESCIEN WITH A FATTY ACID HAVING 8 TO 16 CARBON ATOMS IN A PHARMACEUTICAL CARRIER. THIS NEW METHOD FOR EXAMINING THE EXOCRINE PANCREAS FUNCTION IS CARRIED OUT IN THAT A PREDETERMINED AMOUNT OF A FLUORESCEIN FATTY ACID MONOESTER IS INTRODUCED INTO AND PASSED THROUGH THE PASTROINTESTINAL TRACT, THEN THE URINE IS COLLECTED OR A PORTION OF BLOOD SERUM IS WITHDRAWN AND THE AMOUNT OF RELEASED FLUORESCEIN CONTAINED IN THE URINE OR THE BLOOD SERUM IS DETERMINED ANALYTICALLY.
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