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    Diagnostic agent for use in the determination of hydroperoxides and of peroxidate-active substances
    1.
    发明授权
    Diagnostic agent for use in the determination of hydroperoxides and of peroxidate-active substances 失效
    诊断用于确定水合氧化物和过氧化物活性物质的诊断试剂

    公开(公告)号：US3630847A

    公开(公告)日：1971-12-28

    申请号：US3630847D

    申请日：1968-07-17

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： REY HANS-GEORG ,  WIELINGER HANS ,  RIECKMANN PETER

    IPC分类号： G01N33/50 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N31/14

    CPC分类号： C12Q1/28 ,  C12Q1/54 ,  C12Q2326/00 ,  Y10S435/805 ,  Y10S436/904

    摘要： IN WHICH R1 is hydroxyl, unsubstituted or substituted amino, wherein the substituent is an aliphatic, araliphatic, cycloaliphatic, heterocyclic or aromatic radical, which in turn is substituted by one or more of hydroxy, amino and alkoxy; R3, R2 and R5 are each one of hydrogen, amino, hydroxy or alkoxy and R4 is hydrogen or the substituent R1. The diagnostic agents can be used for analytical determinations involving, for example, glucose, galactose, amino acids, uric acid, peroxide, hemoglobin, peroxidase, etc. in samples, for example, constituting biological fluids such as blood, urine, spinal fluid, etc., milk, cosmetic and drug formulations, etc.

    Diagnostic agents suitable for use in carrying out rapid analytical determinations of the presence and/or concentration of hydroperoxide substances which react with the liberation of hydrogen peroxide, peroxidase and peroxidate active substances comprising an indicator, i.e., chromogen, which is oxidized by hydrogen peroxide, peroxidase or peroxidate active substances to form a dyestuff, the color intensity of which is dependent on the peroxide, peroxidase or peroxidate active substance present in the test sample, wherein the chromogen is a compound having the formula:

    Diagnostic agent for detecting bilirubin
    2.
    发明授权
    Diagnostic agent for detecting bilirubin 失效
    用于检测胆红素的诊断剂

    公开(公告)号：US3880588A

    公开(公告)日：1975-04-29

    申请号：US38224173

    申请日：1973-07-24

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： RITTERSDORF WALTER ,  GUTHLEIN WERNER ,  BERGER DIETER ,  REY HANS-GEORG ,  RIECKMANN PETER

    IPC分类号： G01N33/72 ,  G01N31/22 ,  G01N33/16

    CPC分类号： G01N33/728 ,  Y10S436/903 ,  Y10T436/146666

    摘要： WHEREIN X is a stabilizing anion; R1 and R2, which may be the same or different, are halogen or lower alkyl or alkoxy and R3 and R4, which may be the same or different, are hydrogen, halogen, nitro, or lower alkyl or alkoxy; THE AROMATIC RING IN FORMULA (I) containing either (a) 1 to 3 halogen atoms or (b) one nitro group, but not both together; and an amount of an acid sufficient for a coupling reaction between bilirubin and said diazonium salt.

    Bilirubin, particularly as contained in body fluids, is determined with test strips comprising an absorbent

    摘要翻译： 特别是包含在体液中的胆红素由包含吸收剂的测试条确定，其中X是稳定的阴离子; R 1和R 2可以相同或不同，为卤素或低级烷基或烷氧基，R 3和R 4可以相同或不同，为氢，卤素，硝基或低级烷基或烷氧基; 式（I）中的芳族环（I）含有（a）1至3个卤素原子或（b）一个硝基，但不包括在一起; 以及一定量的足以用于胆红素与所述重氮盐之间的偶联反应的酸。

    Diagnostic agent
    4.
    发明授权
    Diagnostic agent 失效
    诊断代理

    公开(公告)号：US3668076A

    公开(公告)日：1972-06-06

    申请号：US3668076D

    申请日：1969-06-17

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： REY HANS-GEORG ,  WIELINGER HANS ,  RIECKMANN PETER

    IPC分类号： G01N33/50 ,  C12Q1/28 ,  C12Q1/54 ,  G01N33/00 ,  G01N31/14

    CPC分类号： C12Q1/28 ,  C12Q1/54 ,  C12Q2326/00 ,  Y10S435/805 ,  Y10S436/904 ,  Y10T436/144444 ,  Y10T436/148888 ,  Y10T436/206664

    摘要： Diagnostic agent suitable for use in carrying out rapid analytical determinations of the presence and/or concentration of hydroperoxides, substances which react with the liberation of hydrogen peroxide, peroxidase or peroxidate active substances, comprising a chromogen which is oxidized by hydroperoxide in the presence of peroxidase or peroxidate active substances to form a dyestuff, the color intensity of which is dependent on the quantity of peroxide, peroxidase or peroxidate active substance present in the test sample, wherein the chromogen is a compound having the formula: WHEREIN Y is hydroxyl, mercapto, or amino, Z is hydroxyl, wherein Y AND Z together can represent oxygen, and R is hydrogen, mercapto, amino, lower alkyl, pyridino, morpholino, piperazinyl, arylpiperazinyl, phenyl, or phenyl substituted by one or more of hydroxyl, nitro, alkyl or alkoxyl.

    Diagnostic agents for use in the determination of hydroperoxides and of peroxidate-active substances and methods for manufacturing and using the same
    7.
    发明授权
    Diagnostic agents for use in the determination of hydroperoxides and of peroxidate-active substances and methods for manufacturing and using the same 失效
    用于确定氢过氧化物和过氧化物活性物质的诊断试剂及其制备和使用方法

    公开(公告)号：US3558435A

    公开(公告)日：1971-01-26

    申请号：US3558435D

    申请日：1967-08-04

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： REY HANS-GEORG ,  WIELINGER HANS ,  RIECKMANN PETER

    IPC分类号： G01N33/50 ,  C12Q1/28 ,  C12Q1/54 ,  G01N33/00 ,  G01N31/14 ,  G01N31/22

    CPC分类号： C12Q1/28 ,  C12Q1/54 ,  C12Q2326/00 ,  Y10S435/805 ,  Y10S436/904 ,  Y10T436/144444 ,  Y10T436/148888 ,  Y10T436/206664

    摘要： THERE ARE DISCLOSED DIAGNOSTIC AGENTS SUITABLE FOR USE IN CARRYING OUT RAPID ANALYTICAL DETERMINATIONS OF THE PRESENCE AND/OR CONCENTRATION OF HYDROPEROXIDE, SUBSTANCES WHICH REACT WITH THE LIBERATION OF JYDROGEN PEROXIDE, PEROXIDASE AND PEROXIDATE-ACTIVE SUBSTANCES. THE DIAGNOSTIC AGENTS OF THE INVENTION ARE ADAPTED FOR USE IN TEST PROCEDURES INVOLVING OPTICAL INSTUMENTS SUCHAS COLORMETERS AND PHOTOMETERS AND ALSO IN TEST PROCEDURES INVOLVING TEST PAPERS. THE DIAGNOSTIC AGENTS AS TAUGHT HEREIN COMPRISE AN INDICATOR I.E., CHROMOGEN, WHICH IS OXIDIZED BY HYDROGEN PEROXIDE AND PEROXIDASE OR PEROSIDATE ACTIVE SUBSTANCES TO FORM A DYESTUFF WHOSE INTENSITY IS DEPENDENT ON THE CONCENTRATION OF THE PEROXIDE, PEROXIDASE OR PEROXIDATE ACTIVE SUBSTANCE PRESENT IN THE TEST SAMPLE. THE INDICATOR I.E., CHROMOGEN IS A COMPOUND OF THE FORMULA:

    (R4,R5,R6-PHENYL)-C(-R3)=N-(N(-R2))N-C(=X)-R1

    WHERIN R1 IS AMINO OR AN ALIPHATIC, ARALIPHATIC, AROMATIC OR HETEROCYCLIC RADICAL WHICH MAY CARRY ONE OR MORE SUBSTITUENTS, OR A GROUP HAVING THE FORMULA:

    (R4,R5,R6-PHENYL)-C(-R3)=N-(N(-R2))N-C(=X)-(CH(-OH))M-

    WHEREIN R2 IS HYDROGEN, AN ALIPHATIC, AROMATIC OR HETEROCYCLIC RADICAL WHICH MAY CARRY ONE OR MORE SUBSTITUENTS, R3 IS HYDROGEN, ALKYL OR PHENYL AND MAY BE MONO- OR POLY SUBSTITUTED, R4 IS AMINO, HYDROXYL OR ALKOXY, R5 AND R6 ARE EACH HYDROGEN, AMINO, HYDROXY,ALKOXY OR ALKYL, X IS OXYGEN, SULFUR OR IMINO WHICH MAY BE SUBSTITUTED BY A GROUP AS DEFINED BY R1, N IS 0 OR 1, M IS 0,1 OR 2; AND WHEREIN X AND R1 AND R2 OR R1 AND R3 CAN BE JOINED TOGETHER TO FORM A RING. THE DIAGNOSTIC AGENTS CAN BE USED FOR ANALYTICAL DETERMINATIONS INVOLVING, FOR EXAMPLE, GLUCOSE, GALACTOSE, AMINO ACIDS, URIC ACID, PEROXIDE, HEMOGLOBIN, PEROXIDASE, ETC. IN SAMPLES, FOR EXAMPLE, CONSTITUTING BIOLOGICAL FLUIDS SUCH AS BLOOD, URINE, SPINAL FLUID, ETC., MILK, COSMETIC AND DRUG FORMULATIONS, ETC.

    摘要翻译： 适用于进行快速分析测定氢过氧化物，与释放过氧化氢，过氧化物酶或过氧化物活性物质反应的物质的快速分析测定，包括在过氧化物酶存在下被氢过氧化物氧化的色原体 或过氧化物活性物质形成染料，其颜色强度取决于测试样品中存在的过氧化物，过氧化物酶或过氧化物活性物质的量，其中色原是具有下式的化合物：

    Diagnostic device and method for the diagnosis of mucoviscidosis (cystic fibrosis)
    8.
    发明授权
    Diagnostic device and method for the diagnosis of mucoviscidosis (cystic fibrosis) 失效
    诊断器官和诊断粘液性纤维化的方法（囊性纤维化）

    公开(公告)号：US3902847A

    公开(公告)日：1975-09-02

    申请号：US34958373

    申请日：1973-04-09

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： BUSCH ERNST-WERNER ,  LANGE HANS ,  REY HANS-GEORG ,  RITTERSDORF WALTER

    IPC分类号： G01N33/52 ,  G01N33/68 ,  G01N33/16 ,  G01N21/06 ,  G01N31/08

    CPC分类号： G01N33/526 ,  G01N33/6839

    摘要： Mucoviscidosis (cystic fibrosis) is detected in its early stages, particularly in the large-scale screening in newborn infants, by means of measuring the pathologically elevated protein content in the meconium, using a diagnostic agent comprising a protein test strip sealed to a longer plastic strip, applying meconium to the (flush) bottom portion of the combined strip, immersing the smeared portion of the strip in water, permitting water to wet the strip by ascending chromatography, and reading a color change in the strip as an indication of elevated protein content in the meconium.

    摘要翻译： 通过使用包含密封到较长塑料的蛋白质测试条的诊断试剂，通过测量胎粪中的病理学升高的蛋白质含量，在其早期阶段检测到粘液性软骨病（囊性纤维化），特别是在新生儿的大规模筛查中 将胎粪施加到组合条的（冲洗）底部，将条带的涂抹部分浸入水中，允许水通过上升色谱法润湿条带，并读取条带中的颜色变化作为升高的蛋白质的指示 胎粪中的含量