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公开(公告)号：US20170252144A1
公开(公告)日：2017-09-07
申请号：US15450636
申请日：2017-03-06
发明人： Michelle Hannon , Nigel McMenamin , Matthew Montague , Michael G. Folan , Alexandre Lambert , Brian Joyce , Megan Niven , Allison M. Pearlman
CPC分类号： A61F2/04 , A61F2/2412 , A61F2/2418 , A61F2002/044 , A61F2210/0014 , A61F2210/0076 , A61F2230/0021 , A61F2230/0067
摘要： An example medical device is disclosed. The example medical device includes a tubular scaffold. The scaffold includes a longitudinal axis, an inner surface and an outer surface. The medical device also includes a flexible valve extending radially inward from the inner surface of the scaffold. The valve includes an annular chamber extending circumferentially around the inner surface of the scaffold and is configured to shift from a closed configuration to an open configuration.
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公开(公告)号：US11744693B2
公开(公告)日：2023-09-05
申请号：US16596061
申请日：2019-10-08
发明人： Michelle Hannon , Nigel McMenamin , Matthew Montague , Michael G. Folan , Alexandre Lambert , Brian Joyce , Megan Niven , Allison M. Pearlman
CPC分类号： A61F2/04 , A61F2/2412 , A61F2/2418 , A61F2/958 , A61L27/025 , A61L27/30 , A61L27/56 , B05D1/02 , A61F2002/044 , A61F2210/0014 , A61F2210/0076 , A61F2230/0021 , A61F2230/0067 , A61L27/3679
摘要： An example medical device is disclosed. The example medical device includes a tubular scaffold. The scaffold includes a longitudinal axis, an inner surface and an outer surface. The medical device also includes a flexible valve extending radially inward from the inner surface of the scaffold. The valve includes an annular chamber extending circumferentially around the inner surface of the scaffold and is configured to shift from a closed configuration to an open configuration.
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公开(公告)号：US10881619B2
公开(公告)日：2021-01-05
申请号：US14980371
申请日：2015-12-28
摘要： In one aspect, the present disclosure provides microparticles that are configured to release a first drug over a first time period and to release a second drug over a second time period, wherein a lag period of substantially no drug release occurs between the first and second time periods. In other aspects, the present disclosure pertains to the use of such microparticles in delivery systems and methods of treatment. In another aspect, the present disclosure pertains to drug delivery systems that comprising a folded inflatable drug delivery balloon that comprises folds and microparticles positioned within the folds.
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4.发明申请COMPOSITIONS, DEVICES AND METHODS FOR MULTI-STAGE RELEASE OF CHEMOTHERAPEUTICS 审中-公开化疗药物多阶段释放的组合物，装置和方法公开(公告)号：US20160184233A1
公开(公告)日：2016-06-30
申请号：US14980371
申请日：2015-12-28
CPC分类号： A61K9/5078 , A61K9/0024 , A61L29/16 , A61L2300/416 , A61M25/1002 , A61M2025/1004 , A61M2025/105
摘要： In one aspect, the present disclosure provides microparticles that are configured to release a first drug over a first time period and to release a second drug over a second time period, wherein a lag period of substantially no drug release occurs between the first and second time periods. In other aspects, the present disclosure pertains to the use of such microparticles in delivery systems and methods of treatment. In another aspect, the present disclosure pertains to drug delivery systems that comprising a folded inflatable drug delivery balloon that comprises folds and microparticles positioned within the folds.
摘要翻译： 一方面，本公开提供了微粒，其构造成在第一时间段内释放第一药物并且在第二时间段内释放第二药物，其中在第一和第二时间之间基本上不发生药物释放的滞后期 时期。 在其他方面，本公开涉及这种微粒在递送系统和治疗方法中的用途。 在另一方面，本公开涉及药物递送系统，其包括折叠的可膨胀药物递送球囊，其包括位于折叠内的褶皱和微粒。
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公开(公告)号：US20210085616A1
公开(公告)日：2021-03-25
申请号：US17109633
申请日：2020-12-02
摘要： In one aspect, the present disclosure provides microparticles that are configured to release a first drug over a first time period and to release a second drug over a second time period, wherein a lag period of substantially no drug release occurs between the first and second time periods. In other aspects, the present disclosure pertains to the use of such microparticles in delivery systems and methods of treatment. In another aspect, the present disclosure pertains to drug delivery systems that comprising a folded inflatable drug delivery balloon that comprises folds and microparticles positioned within the folds.
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公开(公告)号：US20200030078A1
公开(公告)日：2020-01-30
申请号：US16596061
申请日：2019-10-08
发明人： Michelle Hannon , Nigel McMenamin , Matthew Montague , Michael G. Folan , Alexandre Lambert , Brian Joyce , Megan Niven , Allison M. Pearlman
摘要： An example medical device is disclosed. The example medical device includes a tubular scaffold. The scaffold includes a longitudinal axis, an inner surface and an outer surface. The medical device also includes a flexible valve extending radially inward from the inner surface of the scaffold. The valve includes an annular chamber extending circumferentially around the inner surface of the scaffold and is configured to shift from a closed configuration to an open configuration.
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公开(公告)号：US10022519B2
公开(公告)日：2018-07-17
申请号：US14997156
申请日：2016-01-15
发明人： Philip Bannister , Brenda Clarke , Gill Aoibheann , Michelle Hannon , Dwayne Noone , Fengnan Fang , Emma Jane Mooney , John Kilcooley , Javier Palomar-Moreno , Aiden Flanagan , Tim O'Connor
IPC分类号： A61M25/00 , A61B5/042 , A61B5/00 , A61M25/01 , A61M25/06 , A61M37/00 , A61B17/00 , A61B17/34 , A61B18/14
摘要： An injection catheter system that includes (a) an actuator; (b) an outer needle comprising a sharp tip and a tubular body defining a lumen, and extending distally from the actuator; and (c) an inner needle at least partially disposed within the lumen and extending distally from the actuator, the inner needle having a distal tip configured such that at least a portion of the distal tip has a surface contour with an interstitial cavity adapted to receive a therapeutic gel. The system is configured such that (a) in a first position, the distal tip is fully disposed within the lumen to temporarily retain the therapeutic gel in the interstitial cavity and (b) in a second position, the outer needle is retracted proximally, exposing the interstitial cavity to deliver the therapeutic gel to a target area in a body.
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公开(公告)号：US20230363885A1
公开(公告)日：2023-11-16
申请号：US18354287
申请日：2023-07-18
发明人： Michelle Hannon , Nigel McMenamin , Matthew Montague , Michael G. Folan , Alexandre Lambert , Brian Joyce , Megan Niven , Allison M. Pearlman
CPC分类号： A61F2/04 , A61F2/2412 , A61F2/2418 , A61F2/958 , A61L27/025 , A61L27/30 , A61L27/56 , B05D1/02 , A61F2002/044 , A61F2210/0014 , A61F2210/0076 , A61F2230/0021 , A61F2230/0067 , A61L27/3679
摘要： An example medical device is disclosed. The example medical device includes a tubular scaffold. The scaffold includes a longitudinal axis, an inner surface and an outer surface. The medical device also includes a flexible valve extending radially inward from the inner surface of the scaffold. The valve includes an annular chamber extending circumferentially around the inner surface of the scaffold and is configured to shift from a closed configuration to an open configuration.
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公开(公告)号：US11672765B2
公开(公告)日：2023-06-13
申请号：US17109633
申请日：2020-12-02
CPC分类号： A61K9/5078 , A61K9/0024 , A61L29/16 , A61M25/1002 , A61L2300/416 , A61M2025/1004 , A61M2025/105
摘要： In one aspect, the present disclosure provides microparticles that are configured to release a first drug over a first time period and to release a second drug over a second time period, wherein a lag period of substantially no drug release occurs between the first and second time periods. In other aspects, the present disclosure pertains to the use of such microparticles in delivery systems and methods of treatment. In another aspect, the present disclosure pertains to drug delivery systems that comprising a folded inflatable drug delivery balloon that comprises folds and microparticles positioned within the folds.
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公开(公告)号：US20230043660A1
公开(公告)日：2023-02-09
申请号：US17880126
申请日：2022-08-03
摘要： An ostial stent delivery device may include a first elongate shaft including a first lumen and extending along a central longitudinal axis, wherein the first elongate shaft includes a first inflatable balloon fixedly attached proximate a distal end of the first elongate shaft; and a second elongate shaft including a second lumen, the first elongate shaft being at least partially disposed within the second lumen. The second elongate shaft includes a second inflatable balloon fixedly attached proximate a distal end of the second elongate shaft. The second inflatable balloon is disposed at least partially proximal of the first inflatable balloon. The first inflatable balloon has a substantially cylindrical shape along a majority of its length in the deployed configuration. The second inflatable balloon has a substantially biconical shape having a central axis oriented parallel to the central longitudinal axis in the deployed configuration.
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