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公开(公告)号:US20220298535A1
公开(公告)日:2022-09-22
申请号:US17750293
申请日:2022-05-20
Applicant: Braskem S.A.
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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公开(公告)号:US20220064682A1
公开(公告)日:2022-03-03
申请号:US17463988
申请日:2021-09-01
Applicant: Braskem S.A.
Inventor: Iuri Estrada GOUVEA , Ana Karina BRAMBILLA COSTA , Marcos Rogerio SIMOES , Veronica Leite QUEIROZ , Aline Silva ROMÃO DUMARESQ
Abstract: The present disclosure provides recombinant microorganisms and methods for the anaerobic production of 2,4-furandimethanol from one or more carbon sources. The microorganisms and methods provide redox-balanced and ATP positive pathways for co-producing 2,4-furandimethanol with ethanol and for co-producing 2,4-furandimethanol with ethanol and acetone and/or isopropanol. The method provides recombinant microorganisms that express endogenous and/or exogenous nucleic acid molecules encoding polypeptides that catalyze the conversion of a carbon source into 2,4-furandimethanol and that couple the 2,4-furandimethanol pathway with an additional metabolic pathway. The present disclosure further provides enzymatic production of 2,4-furandicarboxylic acid.
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公开(公告)号:US20230279365A1
公开(公告)日:2023-09-07
申请号:US18084888
申请日:2022-12-20
Applicant: Braskem S.A.
Inventor: Verônica Leite QUEIROZ , Lucas Pedersen PARIZZI , Iuri Estrada GOUVEA , Debora Noma OKAMOTO , Rafael Victório Carvalho GUIDO , Alessandro Silva NASCIMENTO , Igor POLIKARPOV
CPC classification number: C12N9/0006 , C12N15/52 , C12Y101/01001
Abstract: The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.
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公开(公告)号:US20210238639A1
公开(公告)日:2021-08-05
申请号:US17219792
申请日:2021-03-31
Applicant: Braskem S.A.
Inventor: Paulo Moises Raduan ALEXANDRINO , Iuri Estrada GOUVEA , Veronica Leite QUEIROZ , Felipe Cicaroni FERNANDES , Bárbara MANO
IPC: C12P17/04 , C07D307/68
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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公开(公告)号:US20220243006A1
公开(公告)日:2022-08-04
申请号:US17586535
申请日:2022-01-27
Applicant: Braskem S.A.
Inventor: Felipe Cicaroni FERNANDES , Iuri Estrada GOUVEA , Bárbara MANO
IPC: C08G63/183 , C08G63/40
Abstract: The present disclosure provides a copolyester including a dicarboxylic acid component A comprising a terephthalic acid residue or ester-forming derivative thereof, or a mixture thereof, and a 2,4-furandicarboxylic acid residue or ester-forming derivative thereof, or a mixture thereof, and a diol component B comprising an alkanediol residue having from 2 to 22 carbon atoms, wherein the dicarboxylic acid component A has a total molar content, and wherein the 2,4-furandicarboxylic acid residue or ester-forming derivative thereof, is present in an amount of from 0.1 to 10 mol %, with respect to the total molar content of the dicarboxylic acid component A. Inventive copolyesters have a slower crystallization rate, a higher gas barrier to CO2 and O2 and a higher ratio of 14C to 12C as measured by ASTM D6866 when compared to a comparable copolyester comprising isophthalic acid instead of 2,4-furandicarboxylic acid.
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公开(公告)号:US20210222217A1
公开(公告)日:2021-07-22
申请号:US17163838
申请日:2021-02-01
Applicant: Braskem S.A.
Inventor: Paulo Moises Raduan ALEXANDRINO , Iuri Estrada GOUVEA , Veronica Leite QUEIROZ , Marcos Rogerio SIMÕES
IPC: C12P17/04 , C07D307/68
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-IMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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公开(公告)号:US20200277639A1
公开(公告)日:2020-09-03
申请号:US16806728
申请日:2020-03-02
Applicant: Braskem S.A.
IPC: C12P17/04 , C07D307/68
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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公开(公告)号:US20190309266A1
公开(公告)日:2019-10-10
申请号:US16378209
申请日:2019-04-08
Applicant: Braskem S.A.
Inventor: Verônica Leite QUEIROZ , Lucas Pedersen PARIZZI , Iuri Estrada GOUVEA , Debora Noma OKAMOTO , Rafael Victório Carvalho GUIDO , Alessandro Silva NASCIMENTO , Igor POLIKARPOV
Abstract: The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.
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公开(公告)号:US20220090153A1
公开(公告)日:2022-03-24
申请号:US17545616
申请日:2021-12-08
Applicant: Braskem S.A.
Inventor: Iuri Estrada GOUVEA , Paulo Moises Raduan ALEXANDRINO
IPC: C12P17/04 , C07D307/68
Abstract: The present disclosure provides recombinant microorganisms and methods for the production of 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA from a carbon source. The method provides for engineered microorganisms that express endogenous and/or exogenous nucleic acid molecules that catalyze the conversion of a carbon source into 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA. The disclosure further provides methods of producing polymers derived from 4-HMF, 2,4-furandimethanol, furan-2,4-dicarbaldehyde, 4-(hydroxymethyl)furoic acid, 2-formylfuran-4-carboxylate, 4-formylfuran-2-carboxylate, and/or 2,4-FDCA.
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公开(公告)号:US20220064683A1
公开(公告)日:2022-03-03
申请号:US17464139
申请日:2021-09-01
Applicant: Braskem S.A.
Inventor: Iuri Estrada GOUVEA , Marcos Rogerio Simoes , Mariana Trovo Marchesin , Aline Silva Romao Dumaresq
Abstract: The present disclosure provides recombinant microorganisms and methods for the anaerobic production of 2,4-furandicarboxylic acid from one or more carbon sources. The microorganisms and methods provide redox-balanced and ATP positive pathways for co-producing 2,4-furandicarboxylic acid with ethanol and for co-producing 2,4-furandicarboxylic acid with ethanol and 1-propanol. The method provides recombinant microorganisms that express endogenous and/or exogenous nucleic acid molecules encoding polypeptides that catalyze the conversion of a carbon source into 2,4-furandicarboxylic acid and that coupled the 2,4-furandicarboxylic acid pathway with an additional metabolic pathway.
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