公开(公告)号：US11236048B2

公开(公告)日：2022-02-01

申请号：US16624448

申请日：2018-06-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Albert J. Delmonte ,  Benjamin M. Cohen ,  Kenneth Joseph Fraunhoffer ,  Sergei Kolotuchin ,  Francisco Gonzalez-Bobes ,  Gregory Louis Beutner ,  Adam Joseph Freitag ,  Michael Scott Bultman ,  Yu Fan ,  Prantik Maity ,  Ian Scott Young ,  Hilary Plake Beck ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky

IPC: C07D215/18 ,  C07C67/343 ,  C07C67/333 ,  C07C51/09

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

公开(公告)号：US11919863B2

公开(公告)日：2024-03-05

申请号：US17552929

申请日：2021-12-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Albert J. Delmonte ,  Benjamin M. Cohen ,  Kenneth Joseph Fraunhoffer ,  Sergei Kolotuchin ,  Francisco Gonzalez-Bobes ,  Gregory Louis Beutner ,  Adam Joseph Freitag ,  Michael Scott Bultman ,  Yu Fan ,  Prantik Maity ,  Ian Scott Young ,  Hilary Plake Beck ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky

IPC: C07D215/18 ,  C07C51/09 ,  C07C67/333 ,  C07C67/343

CPC classification number: C07D215/18 ,  C07C51/09 ,  C07C67/333 ,  C07C67/343

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

公开(公告)号：US20220064205A1

公开(公告)日：2022-03-03

申请号：US17299087

申请日：2019-12-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael Anthony Schmidt ,  Bin Zheng Kendall Park ,  Benjamin M. Cohen ,  Amanda J. Rogers ,  Changxia Yuan Warren ,  Jason J. Zhu ,  Chao Hang ,  Daniel S. Treitler ,  Adam Josep Freitag ,  Geoffrey Eugene Purdum ,  Miao Yu ,  Melda Sezen Edmonds ,  Siwei Guo

IPC: C07H21/00 ,  C07H1/00 ,  C07H19/16 ,  C07H19/20

Abstract: The invention generally relates to an improved processes for the preparation of a cyclic dinucleotide which is useful as a STING agonist of the following formula (I), involving the use of compounds A and B.