公开(公告)号：US11339185B2

公开(公告)日：2022-05-24

申请号：US16683667

申请日：2019-11-14

Applicant: Bristol-Myers Squibb Company

Inventor： Brian E. Fink ,  Dharmpal S. Dodd ,  Steven J. Walker ,  Libing Chen ,  Yufen Zhao ,  Zheming Ruan ,  Lan-Ying Qin ,  Peter Kinam Park ,  Muthoni G. Kamau ,  Lalgudi S. Harikrishnan

IPC: C07H19/213 ,  A61P35/00 ,  C07H21/02 ,  C07H21/00 ,  C07K16/28

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US20220306630A1

公开(公告)日：2022-09-29

申请号：US17632909

申请日：2020-08-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Lalgudi S. Harikrishnan ,  Peter Kinam Park ,  Zheming Ruan ,  Donna D. Wei ,  Daniel O'Malley ,  Honghe Wan ,  Ashok Vinayak Purandare ,  Brian E. Fink

IPC: C07D471/10 ,  C07C317/18 ,  C07D213/73 ,  C07D213/71 ,  C07C255/60 ,  C07D213/82 ,  C07D231/12 ,  C07D231/18 ,  C07D263/24 ,  C07D213/56 ,  C07D401/12 ,  C07C311/16 ,  C07D213/69 ,  C07D233/61 ,  C07D211/34 ,  C07D235/18 ,  C07D213/58 ,  C07D211/96 ,  C07D295/26

Abstract: The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US10519187B2

公开(公告)日：2019-12-31

申请号：US16272172

申请日：2019-02-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Brian E. Fink ,  Dharmpal S. Dodd ,  Steven J. Walker ,  Libing Chen ,  Yufen Zhao ,  Zheming Ruan ,  Lan-Ying Qin ,  Peter Kinam Park ,  Muthoni G. Kamau ,  Lalgudi S. Harikrishnan

IPC: C07H19/213 ,  A61P35/00 ,  C07K16/28

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US20230322803A1

公开(公告)日：2023-10-12

申请号：US17913206

申请日：2021-03-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Andrew P. Degnan ,  Godwin Kwame Kumi ,  Andrew J. Tebben ,  Audris Huang ,  Peter Kinam Park ,  Donna M. Bilder ,  Emily Charlotte Cherney ,  Ashok Vinayak Purandare

IPC: C07D498/04 ,  C07D471/04 ,  C07D401/14

CPC classification number: C07D498/04 ,  C07D401/14 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein Ring A is a carbon-linked ring; and Ring A, R1, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

公开(公告)号：US20200079815A1

公开(公告)日：2020-03-12

申请号：US16683667

申请日：2019-11-14

Applicant: Bristol-Myers Squibb Company

Inventor： Brian E. FINK ,  Dharmpal S. Dodd ,  Steven J. Walker ,  Libing Chen ,  Yufen Zhao ,  Zheming Ruan ,  Lan-Ying Qin ,  Peter Kinam Park ,  Muthoni G, Kamau ,  Lalgudi S. Harikrishnan

IPC: C07H19/213 ,  A61P35/00 ,  C07H21/02 ,  C07H21/00

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.

公开(公告)号：US20190248828A1

公开(公告)日：2019-08-15

申请号：US16272172

申请日：2019-02-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Brian E. Fink ,  Dharmpal S. Dodd ,  Steven J. Walker ,  Libing Chen ,  Yufen Zhao ,  Zheming Ruan ,  Lan-Ying Qin ,  Peter Kinam Park ,  Muthoni G. Kamau ,  Lalgudi S. Harikrishnan

IPC: C07H19/213 ,  A61P35/00

Abstract: The present invention is directed to compounds of the formulae I, II and III as shown below wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.