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公开(公告)号：US11066392B2
公开(公告)日：2021-07-20
申请号：US16612076
申请日：2018-05-10
发明人： James Aaron Balog , Emily Charlotte Cherney , Liping Zhang , Audris Huang , Weifang Shan , David K. Williams , Xiao Zhu , Weiwei Guo
IPC分类号： A61P35/00 , A61K31/444 , A61K31/4709 , A61K31/4375 , A61K31/497 , A61K31/506 , C07D401/12 , C07D403/12 , C07D471/04 , C07D213/85
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US10544099B2
公开(公告)日：2020-01-28
申请号：US16098260
申请日：2017-05-04
IPC分类号： C07D215/18 , C07D215/233 , C07D401/04 , A61P35/00 , A61K31/47 , A61K31/4709 , A61K45/06
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US09637518B2
公开(公告)日：2017-05-02
申请号：US14903306
申请日：2014-07-10
发明人： Kyoung S. Kim , Liping Zhang , Erik M. Stang
CPC分类号： C07K5/0806 , A61K38/00 , A61K38/06 , A61K45/06 , C07K14/4747 , C07K14/8139
摘要： There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US09738630B2
公开(公告)日：2017-08-22
申请号：US15037081
申请日：2014-11-18
IPC分类号： C07D405/12 , C07D401/14 , C07D413/14 , A61K31/4725 , C07D407/14 , C07D417/14 , A61K45/06 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D405/14
CPC分类号： C07D405/12 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , Y02A50/411 , Y02A50/414 , A61K2300/00
摘要： There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases, utilizing the compounds of the invention.
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公开(公告)号：US20160176871A1
公开(公告)日：2016-06-23
申请号：US14977709
申请日：2015-12-22
发明人： Brian E. Fink , Yufen Zhao , Robert M. Borzilleri , Liping Zhang , Kyoung S. Kim , Muthoni G. Kamau , Andrew J. Tebben
IPC分类号： C07D471/04 , A61K31/506 , A61K31/4709 , A61K31/501 , A61K31/4985 , A61K31/5377 , A61K31/496 , A61K31/541 , A61K31/437 , C07D487/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D487/04 , Y02P20/582
摘要： The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
摘要翻译： 本发明一般涉及调节TGF-bgr R-1和TGF-bgr R-2的活性的化合物，含有所述化合物的药物组合物和使用本发明化合物治疗增殖性疾病和失调性细胞凋亡障碍（例如癌症）的方法 。
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公开(公告)号：US11351164B2
公开(公告)日：2022-06-07
申请号：US16328473
申请日：2017-08-25
IPC分类号： A61K31/4709 , A61K39/395 , C07D401/08 , C07D401/12 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/08 , C07D417/12 , C07D417/14
摘要： There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compound and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US09708316B2
公开(公告)日：2017-07-18
申请号：US14977709
申请日：2015-12-22
发明人： Brian E. Fink , Yufen Zhao , Robert M. Borzilleri , Liping Zhang , Kyoung S. Kim , Muthoni G. Kamau , Andrew J. Tebben , Yong Zhang , Andrew F. Donnell
IPC分类号： A61K31/4709 , A61K31/501 , C07D487/04 , C07D471/04 , A61K31/5377 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/541
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D487/04 , Y02P20/582
摘要： The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US20160297806A1
公开(公告)日：2016-10-13
申请号：US15037081
申请日：2014-11-18
IPC分类号： C07D405/12 , A61K31/5377 , A61K31/496 , C07D417/14 , C07D405/14 , A61K45/06 , A61K31/541
CPC分类号： C07D405/12 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D405/14 , C07D407/14 , C07D413/14 , C07D417/14 , Y02A50/411 , Y02A50/414 , A61K2300/00
摘要： There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative, inflammatory, infectious, and immunoregulatory disorders and diseases, utilizing the compounds of the invention.
摘要翻译： 公开了作为EZH2抑制剂的化合物，含有所述化合物的药物组合物和利用本发明化合物治疗过度增殖，炎症，感染和免疫调节性疾病和疾病的方法。
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公开(公告)号：US20150238558A1
公开(公告)日：2015-08-27
申请号：US14432517
申请日：2013-10-01
发明人： Kyoung S. Kim , Liping Zhang , Donna D. Wei
CPC分类号： A61K38/08 , A61K38/00 , A61K45/06 , C07K5/0806 , C07K7/06
摘要： There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
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公开(公告)号：US11649212B2
公开(公告)日：2023-05-16
申请号：US16754171
申请日：2018-10-08
IPC分类号： C07D215/46 , C07D215/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07K16/28
CPC分类号： C07D215/46 , C07D215/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07K16/2818
摘要： The present invention provides compounds of formula (I), formula (II) or formula (III), wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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