公开(公告)号：US11236048B2

公开(公告)日：2022-02-01

申请号：US16624448

申请日：2018-06-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Albert J. Delmonte ,  Benjamin M. Cohen ,  Kenneth Joseph Fraunhoffer ,  Sergei Kolotuchin ,  Francisco Gonzalez-Bobes ,  Gregory Louis Beutner ,  Adam Joseph Freitag ,  Michael Scott Bultman ,  Yu Fan ,  Prantik Maity ,  Ian Scott Young ,  Hilary Plake Beck ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky

IPC: C07D215/18 ,  C07C67/343 ,  C07C67/333 ,  C07C51/09

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

公开(公告)号：US11919863B2

公开(公告)日：2024-03-05

申请号：US17552929

申请日：2021-12-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Albert J. Delmonte ,  Benjamin M. Cohen ,  Kenneth Joseph Fraunhoffer ,  Sergei Kolotuchin ,  Francisco Gonzalez-Bobes ,  Gregory Louis Beutner ,  Adam Joseph Freitag ,  Michael Scott Bultman ,  Yu Fan ,  Prantik Maity ,  Ian Scott Young ,  Hilary Plake Beck ,  Maksim Osipov ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Hunter Paul Shunatona ,  James Ross Walker ,  Mikhail Zibinsky

IPC: C07D215/18 ,  C07C51/09 ,  C07C67/333 ,  C07C67/343

CPC classification number: C07D215/18 ,  C07C51/09 ,  C07C67/333 ,  C07C67/343

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

公开(公告)号：US20230265050A1

公开(公告)日：2023-08-24

申请号：US18003232

申请日：2021-06-22

Applicant: Bristol-Myers Squibb Company

Inventor： Gregory Louis Beutner ,  Ronald Carrasquillo-Flores ,  Federico Lora Gonzalez ,  Michael J. Smith

IPC: C07C237/22 ,  C07C231/02

CPC classification number: C07C237/22 ,  C07C231/02

Abstract: The present application provides processes for synthesizing cationic lipids of Formula I useful in the synthesis of fat-soluble compositions for targeting and enhancing activity of therapeutic molecules, including siRNA.

公开(公告)号：US20230250056A1

公开(公告)日：2023-08-10

申请号：US18003228

申请日：2021-06-22

Applicant: Bristol-Myers Squibb Company

Inventor： Gregory Louis Beutner ,  Federico Lora Gonzalez ,  Patricia Y. Cho ,  Michael J. Smith

IPC: C07C323/41 ,  C07C319/14

CPC classification number: C07C323/41 ,  C07C319/14

Abstract: The present application provides processes for synthesizing lipids of Formula I useful in the synthesis of fat-soluble compounds for targeting and enhancing activity of therapeutic molecules, including siRNA.