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1.发明申请Pyrazolopyrimidine Macrocycles as Inhibitors of Human Immunodeficiency Virus Replication 有权吡唑并嘧啶大环化合物作为人类免疫缺陷病毒复制的抑制剂公开(公告)号：US20150232481A1
公开(公告)日：2015-08-20
申请号：US14619728
申请日：2015-02-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： B. Narasimhulu Naidu , Michael A. Walker , Margaret E. Sorenson , Manoj Patel , Zhizhen Barbara Zheng , John F. Kadow , Bin Zheng , Martin D. Eastgate , Ke Chen , Francisco Gonzalez-Bobes
IPC: C07D498/22
CPC classification number: C07D498/22 , C07D211/48
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for making and using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及制备和使用这些化合物治疗HIV感染的方法。
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![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2022/06/09/US20220177482A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220177482A1
公开(公告)日：2022-06-09
申请号：US17677312
申请日：2022-02-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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Patent Agency Ranking
![PROCESS FOR THE PREPARATION OF N-((1R,2S,5R)-5-(TERT-BUTYLAMINO)-2-((S)-3-(7-TERT-BUTYLPYRAZOLO[1,5-A][1,3,5]TRIAZIN-4-YLAMINO)-2-OXOPYRROLIDIN-1-YL)CYCLOHEXYL)ACETAMIDE](/abs-image/US/2020/07/16/US20200223852A1/abs.jpg.150x150.jpg)
公开(公告)号：US20200223852A1
公开(公告)日：2020-07-16
申请号：US16631915
申请日：2018-07-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C.D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolodin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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4.发明授权公开(公告)号：US11919863B2
公开(公告)日：2024-03-05
申请号：US17552929
申请日：2021-12-16
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Albert J. Delmonte , Benjamin M. Cohen , Kenneth Joseph Fraunhoffer , Sergei Kolotuchin , Francisco Gonzalez-Bobes , Gregory Louis Beutner , Adam Joseph Freitag , Michael Scott Bultman , Yu Fan , Prantik Maity , Ian Scott Young , Hilary Plake Beck , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky
IPC: C07D215/18 , C07C51/09 , C07C67/333 , C07C67/343
CPC classification number: C07D215/18 , C07C51/09 , C07C67/333 , C07C67/343
Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
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5.发明授权Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication 有权吡唑并嘧啶大环化合物作为人类免疫缺陷病毒复制的抑制剂公开(公告)号：US09273067B2
公开(公告)日：2016-03-01
申请号：US14619728
申请日：2015-02-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： B. Narasimhulu Naidu , Michael A. Walker , Margaret E. Sorenson , Manoj Patel , Zhizhen Barbara Zheng , John F. Kadow , Bin Zheng , Martin D. Eastgate , Ke Chen , Francisco Gonzalez-Bobes
IPC: C07D498/22 , C07D211/48
CPC classification number: C07D498/22 , C07D211/48
Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for making and using these compounds in the treatment of HIV infection.
Abstract translation: 本公开一般涉及式I化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。 本公开提供了HIV的新型抑制剂，含有这些化合物的药物组合物，以及制备和使用这些化合物治疗HIV感染的方法。
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![Process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrroldin-1-yl)cyclohexyl)acetamide](/abs-image/US/2022/02/22/US11254679B2/abs.jpg.150x150.jpg)
公开(公告)号：US11254679B2
公开(公告)日：2022-02-22
申请号：US16631915
申请日：2018-07-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Burcu Selin Aytar , Alina Borovika , Collin Chan , Joerg Deerberg , Nathan R. Domagalski , Martin D. Eastgate , Yu Fan , Michael David Bengt Fenster , Robert V. Forest , Francisco Gonzalez-Bobes , Rebecca A. Green , Matthew R. Hickey , Nathaniel David Kopp , Thomas E. La Cruz , Kathleen Lauser , Hong Geun Lee , David K. Leahy , Helen Y. Luo , Thomas M. Razler , Scott A. Savage , Chris Sfouggatakis , Maxime C. D. Soumeillant , Serge Zaretsky , Bin Zheng , Ye Zhu
IPC: C07D487/04
Abstract: The invention generally relates to an improved process for the preparation of N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, as well as novel intermediates employed in the process, which may be useful for the treatment of cancer.
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7.发明授权公开(公告)号：US11236048B2
公开(公告)日：2022-02-01
申请号：US16624448
申请日：2018-06-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Albert J. Delmonte , Benjamin M. Cohen , Kenneth Joseph Fraunhoffer , Sergei Kolotuchin , Francisco Gonzalez-Bobes , Gregory Louis Beutner , Adam Joseph Freitag , Michael Scott Bultman , Yu Fan , Prantik Maity , Ian Scott Young , Hilary Plake Beck , Maksim Osipov , Jay Patrick Powers , Maureen Kay Reilly , Hunter Paul Shunatona , James Ross Walker , Mikhail Zibinsky
IPC: C07D215/18 , C07C67/343 , C07C67/333 , C07C51/09
Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.
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