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公开(公告)号：US11351164B2
公开(公告)日：2022-06-07
申请号：US16328473
申请日：2017-08-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Liping Zhang , Emily Charlotte Cherney , James Aaron Balog , Xiao Zhu
IPC: A61K31/4709 , A61K39/395 , C07D401/08 , C07D401/12 , C07D413/08 , C07D413/12 , C07D413/14 , C07D417/08 , C07D417/12 , C07D417/14
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compound and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US20190002402A1
公开(公告)日：2019-01-03
申请号：US15737798
申请日：2016-06-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Weifang Shan , David K. Williams
IPC: C07C275/42 , A61K31/196 , A61K45/06 , C07D239/42 , A61K31/505 , C07D213/72 , A61K31/4406 , C07D261/14 , A61K31/42 , C07D285/135 , A61K31/433 , C07D277/38 , A61K31/426 , C07D263/32 , A61K31/421 , C07D209/08 , A61K31/404 , C07C311/46 , A61K31/18 , C07D333/34 , A61K31/381 , C07D239/47 , A61K31/513 , C07D257/04 , A61K31/41
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US10167254B2
公开(公告)日：2019-01-01
申请号：US15584818
申请日：2017-05-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weiwei Guo , Audris Huang , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Natesan Murugesan , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: A61K31/17 , C07C275/40 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/395 , C07C229/42 , C07C255/58 , C07D205/04 , C07D211/14 , C07D239/47 , C07D265/36 , C07D277/64 , C07D295/155 , C07D309/04 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D309/14 , C07D407/12 , C07D487/08 , C07D265/30 , C07D207/08 , C07D211/08 , C07D307/22 , C07C255/57 , C07C235/38 , C07C235/56 , C07C233/81 , C07C275/42 , C07D207/12 , C07D239/34 , C07D317/46 , C07D413/14 , C07D471/08 , C07C275/30 , A61K45/06
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US11203592B2
公开(公告)日：2021-12-21
申请号：US16754175
申请日：2018-10-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Steven P. Seitz , Emily Charlotte Cherney , Xiao Zhu
IPC: C07D471/04 , C07D307/94 , C07D405/06 , C07K16/28
Abstract: The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号：US20180079712A1
公开(公告)日：2018-03-22
申请号：US15564146
申请日：2016-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Audris Huang , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: C07C229/42 , C07C275/42 , C07D295/155 , C07D239/47 , C07D277/64 , C07D335/02 , C07D409/12 , C07D309/14 , C07D405/12 , C07D211/14 , C07D401/12 , C07D317/46 , C07D239/34 , C07D413/12 , C07D265/30 , C07C233/81 , C07D405/14 , C07D207/12 , C07D487/08 , C07D487/04 , C07D471/08 , C07D265/36 , C07D413/14
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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Patent Agency Ranking
公开(公告)号：US20160289171A1
公开(公告)日：2016-10-06
申请号：US15088211
申请日：2016-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weiwei Guo , Audris Huang , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Natesan Murugesan , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: C07C229/42 , A61K31/196 , C07D239/47 , A61K31/505 , C07C255/58 , A61K31/277 , C07C275/40 , A61K31/17 , C07D295/155 , A61K31/5375 , C07D277/64 , A61K31/428 , C07D335/02 , A61K31/382 , C07D409/12 , A61K31/506 , C07D309/04 , A61K31/351 , C07D405/12 , C07D211/14 , A61K31/445 , C07D401/12 , C07D413/12 , A61K31/5377 , C07D405/14 , C07D417/12 , C07D487/04 , A61K31/519 , A61K31/501 , C07D471/04 , A61K31/437 , C07D205/04 , A61K31/397 , A61K31/538 , C07D265/36 , A61K39/395
CPC classification number: C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07C229/42 , C07C233/81 , C07C235/38 , C07C235/56 , C07C255/57 , C07C255/58 , C07C275/30 , C07C275/42 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/08 , C07D211/14 , C07D239/34 , C07D239/47 , C07D265/30 , C07D265/36 , C07D277/64 , C07D295/155 , C07D307/22 , C07D309/04 , C07D309/14 , C07D317/46 , C07D335/02 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Abstract translation: 公开了调节或抑制吲哚胺2,3-双加氧酶（IDO）的酶活性的化合物，含有所述化合物的药物组合物和治疗增殖性疾病如癌症，病毒感染和/或炎症性疾病的方法，其利用 发明。
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公开(公告)号：US11649212B2
公开(公告)日：2023-05-16
申请号：US16754171
申请日：2018-10-08
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Weifang Shan , David K. Williams , Liping Zhang
IPC: C07D215/46 , C07D215/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07K16/28
CPC classification number: C07D215/46 , C07D215/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07K16/2818
Abstract: The present invention provides compounds of formula (I), formula (II) or formula (III), wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.
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公开(公告)号：US11337970B2
公开(公告)日：2022-05-24
申请号：US16328449
申请日：2017-08-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Emily Charlotte Cherney , Weifang Shan , Liping Zhang , Susheel Jethanand Nara , Audris Huang , James Aaron Balog
IPC: A61K31/4709 , A61K31/4375 , A61K31/5025 , A61K31/517 , A61K39/395 , C07D401/08 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/056
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US11066383B2
公开(公告)日：2021-07-20
申请号：US16098245
申请日：2017-05-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： David K. Williams , Weifang Shan , Liping Zhang , Emily Charlotte Cherney , James Aaron Balog
IPC: C07D401/04 , C07D401/06 , C07D215/46 , C07D215/14 , A61P35/00 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/496 , C07D215/18
Abstract: There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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公开(公告)号：US10399932B2
公开(公告)日：2019-09-03
申请号：US15564146
申请日：2016-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Audris Huang , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
IPC: C07D309/14 , C07D405/12 , C07D413/12 , C07D335/02 , C07D211/10 , C07D265/30 , C07D409/12 , C07C275/40 , A61K31/17 , A61K31/196 , A61K31/277 , A61K31/351 , A61K31/382 , A61K31/397 , A61K31/428 , A61K31/437 , A61K31/445 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5375 , A61K31/5377 , A61K31/538 , A61K39/395 , C07C229/42 , C07C255/58 , C07D205/04 , C07D211/14 , C07D239/47 , C07D265/36 , C07D277/64 , C07D295/155 , C07D309/04 , C07D401/12 , C07D405/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D407/12 , C07D487/08 , C07D207/08 , C07D211/08 , C07D307/22 , C07C255/57 , C07C235/38 , C07C235/56 , C07C233/81 , C07C275/42 , C07D207/12 , C07D239/34 , C07D317/46 , C07D413/14 , C07D471/08 , C07C275/30 , A61K45/06
Abstract: There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
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