公开(公告)号：US20210355113A1

公开(公告)日：2021-11-18

申请号：US17261968

申请日：2019-07-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron BALOG ,  Steven P. SEITZ ,  Jay A. MARKWALDER ,  David K. WILLIAMS ,  Weifang SHAN ,  Susheel Jethanand NARA ,  Saumya ROY ,  Srinivas CHERUKU ,  Nagalakshmi PULICHARLA

IPC: C07D405/14 ,  C07D405/10 ,  C07D413/14 ,  C07D313/08 ,  C07D413/10 ,  C07D417/14 ,  C07D307/79 ,  C07K16/28

Abstract: The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

公开(公告)号：US20210221806A1

公开(公告)日：2021-07-22

申请号：US16754175

申请日：2018-10-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Steven P. SEITZ ,  Emily Charlotte CHERNEY ,  Xiau ZHU

IPC: C07D471/04 ,  C07D307/94 ,  C07D405/06 ,  C07K16/28

Abstract: The present invention provides compounds of formula (I): wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

公开(公告)号：US20210070698A1

公开(公告)日：2021-03-11

申请号：US16959487

申请日：2019-01-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James Aaron BALOG ,  Steven P. SEITZ ,  David K. WILLIAMS ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: C07C275/42

Abstract: The present invention provides a compound of formula (II): an inhibitor of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases. Its prodrugs are disclosed.