公开(公告)号：US3769163A

公开(公告)日：1973-10-30

申请号：US3769163D

申请日：1971-11-08

Applicant: BRUMFIELD R

Inventor： BRUMFIELD R

IPC: A61M1/32 ,  A61M1/03

CPC classification number: A61M1/32 ,  A61M1/322 ,  Y10S128/03 ,  Y10S261/28

Abstract: Venous patient blood flows into an oxygenator blood inlet container which is coaxially disposed above an oxygenating gas inlet container. The oxygenating gas enters the blood inlet container through multiple gas injection apertures in a gas distributing manifold plate disposed between the two containers. The above pair of containers are coaxially secured to the base terminus of a vertically aligned, multiple, small diameter aperture, tubular configuration of an oxygen exchange tubular array, the inlet blood container adjacent the base terminus of the exchange tubular array. The gas manifold plate has multiple apertures typically ranging from 120 to 500 microns in diameter, through which the oxygenating gas bubbles into the venous blood. The two-phase flow of blood and oxygenating gas flows upward through the multiple exchange tubular array, the aperture walls stabilizing the two phases. The large surface to volume ratio of gas to blood phase in the tubular array facilitates the rapid fixation of oxygen by the blood, and release of carbon dioxide into the gas phase exiting from the top terminus of the tubular array. The coaxial combination of the inlet oxygen container, the gas manifold plate, the inlet blood container, and the tubular array provide a flow guide useful in blood oxygenator apparatus.

Abstract translation: 静脉血液患者血液流入氧合气入口容器，同时位于氧合气入口容器的上方。 氧化气体通过设置在两个容器之间的气体分配歧管板中的多个气体注入孔进入血液入口容器。 上述一对容器同轴地固定到垂直排列的多个小直径的孔的基本末端，氧交换管阵列的管状构造，入口血液容器邻近交换管阵列的基端。 气体歧管板具有通常范围为120至500微米直径的多个孔，氧合气通过该孔通入静脉血液。 血液和充氧气体的两相流向上流经多个交换管阵列，孔壁稳定两相。 管状阵列中气体与血液相的大表面积与体积比有利于血液中氧气的快速固定，并将二氧化碳释放到从管状阵列顶端排出的气相中。 入口氧气容器，气体歧管板，入口血液容器和管状阵列的同轴组合提供了一种用于血液充氧器装置的流动引导件。

公开(公告)号：US3771899A

公开(公告)日：1973-11-13

申请号：US3771899D

申请日：1971-12-13

Applicant: BRUMFIELD R

Inventor： BRUMFIELD R

IPC: A61M1/10 ,  A61M1/26 ,  F04D5/00 ,  F03B5/00 ,  F04D7/00

CPC classification number: F04D5/001 ,  A61M1/1005 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/102 ,  A61M1/1029 ,  A61M1/1086 ,  A61M1/265 ,  A61M1/267 ,  A61M2205/3334 ,  A61M2205/366 ,  Y10S128/01 ,  Y10S128/03 ,  Y10S415/90

Abstract: A slow variable speed drive rotates a pulsator pump and heat exchanger which can circulate pulsed blood flow extra-corporeally at a required blood temperature to a patient. The pump has a cylindrical rotor shell permanently mounted in a closely fitting internally cylindrical stator housing. The rotor has a support shaft which is eccentrically disposed parallel to the internal axis of symmetry of the stator housing and also to the rotor symmetry axis. Thus the rotor shell has its exterior surface also eccentrically disposed parallel to the rotor shaft axis of symmetry, providing controlled laminar flow of admitted blood. Laminar flow pumping means are provided, together with Taylor mixing vortices. Admitted patient blood is pumped as a thin blood film in pulsed laminar flow between the rotor and stator as the rotor exterior surface eccentrically approaches the stator surface, and in pulsed laminar Taylor vortex flow as the rotor surface recedes from the stator surface. The blood is introduced into the pump through a manifolded blood inlet having a longitudinal groove disposed in the inner face of the stator housing, the groove distributing blood to the annular space between the rotor and stator. A second similar blood outlet combination includes a longitudinal groove in the inner stator face, facilitating blood removal from the pump. The manifolded and jacketed stator housing provides heat transfer means for controlling the temperature of treated-blood of the patient.

Abstract translation: 缓慢的变速驱动器旋转脉动泵和热交换器，其可以将所需血液温度外的脉冲血流脉动流向病人。 泵具有永久安装在紧密配合的内圆柱形定子壳体中的圆柱形转子外壳。 转子具有支承轴，该支撑轴偏心地设置成平行于定子壳体的内对称轴线以及转子对称轴线。

公开(公告)号：US3771658A

公开(公告)日：1973-11-13

申请号：US3771658D

申请日：1971-10-20

Applicant: BRUMFIELD R

Inventor： BRUMFIELD R

IPC: A61M1/32 ,  A61M1/10 ,  A61M1/16 ,  A61M1/26 ,  B01D63/16 ,  B01D31/00

CPC classification number: B01D63/16 ,  A61M1/1005 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/102 ,  A61M1/1029 ,  A61M1/1086 ,  A61M1/1698 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/3334

Abstract: A slow speed drive rotates a cylindrical exchanger pump which operates as a blood oxygenator, and also operates alternatively as a blood dialyser. The pump has a cylindrical rotor permanently mounted in a closely fitting internally cylindrical stator housing. The rotor has a coaxial shaft which is eccentrically disposed parallel to the internal axis of symmetry of the stator housing. Admitted patient blood is pumped as a thin blood film in laminar flow between the rotor and stator as the rotor exterior surface eccentrically approaches the stator surface, and in eddy flow as the rotor surface recedes from the stator surface. The blood is introduced into the pump through a manifolded blood inlet having a longitudinal groove disposed in the inner face of the stator housing, the groove distributing blood to the annular space between the rotor and stator. A second similar blood outlet combination includes a longitudinal groove in the inner stator face, facilitating blood removal from the pump. The rotor has permanent shallow depth passageways disposed in its exterior surface parallel to the rotor shaft axis of symmetry, providing controlled patterned flow of an admitted secondary fluid. The fluid is secured in the rotor passageways by a thin fluidpermeable membrane tightly adjacently covering the passageways. The secondary fluid can be oxygen gas or a liquid dialysate. When oxygenating gas is used, the exchanger pump is a blood oxygenator. When a liquid dialysate is used, the exchanger pump is a blood dialyser. The manifolded and and jacketed stator housing provides heat transfer means for controlling the temperatures of treated-blood of the patient.

Abstract translation: 慢速驱动器旋转作为血液充氧器操作的圆柱形交换器泵，并且也作为血液透析器交替运行。 泵具有永久安装在紧密配合的内圆柱形定子壳体中的圆柱形转子。 该转子具有一个同轴的轴，其偏心地设置成平行于定子壳体的内对称轴线。 当转子外表面偏心地接近定子表面时，并且当转子表面从定子表面退出时，允许的患者血液作为薄片在血液流中被泵送在转子和定子之间的层流中。 血液通过歧管的血液入口引入泵中，血液入口具有设置在定子壳体的内表面中的纵向槽，该槽将血液分配到转子和定子之间的环形空间。 第二类似的血液出口组合包括在内部定子面中的纵向凹槽，便于从泵抽出血液。 转子具有平行于转子轴对称轴线设置在其外表面上的永久性浅深度通道，从而提供允许的次级流体的受控图案化流动。 流体通过紧密地相邻地覆盖通道的薄的液体渗透膜固定在转子通道中。 次级流体可以是氧气或液体透析液。 当使用含氧气体时，交换泵是血液充氧器。 当使用液体透析液时，换热器泵是血液透析器。 歧管和夹套的定子壳体提供用于控制患者的治疗血液的温度的热传递装置。

公开(公告)号：US3769162A

公开(公告)日：1973-10-30

申请号：US3769162D

申请日：1971-08-26

Applicant: BRUMFIELD R

Inventor： BRUMFIELD R

IPC: A61M1/32 ,  A61M1/36 ,  A61M1/03

CPC classification number: A61M1/32 ,  A61M1/325 ,  A61M1/369 ,  Y10S128/03 ,  Y10S261/28

Abstract: Venous human blood flows into a base distributing manifold of a blood oxygenator, whose operating components are cooperatively vertically coaxially disposed. The blood is distributed into vertically aligned multiple, controlled small diameter oxygen exchange tubes, each exchange tube having a coaxial oxygen injection tube disposed at the exchange tube base. Oxygen gas flows through each injection tube, maintaining two-phase flow of oxygen-blood up through the exchange tubes. After oxygenation and separation of excess oxygen and exchanged carbon dioxide gas in a gas separator, the blood is further defoamed in an external coaxial defoamer bed. The defoamed blood then descends a coaxial annular ring in a spiral flow path over a spiral metal tube heat exchanger which contains temperature controlled circulating heat transfer fluid. The oxygenated defoamed blood is thermoregulated to the necessary temperature, exiting from the oxygenator base blood outlet conduit, returning to the patient''s body.

Abstract translation: 静脉的人血液流入血液充氧器的基部分布，其操作部件协同地垂直同轴设置。 血液分布在垂直排列的多个可控的小直径氧气交换管中，每个交换管具有设置在交换管底部的同轴氧气注入管。 氧气流过每个注射管，保持两相血氧通过换管。 在气体分离器中氧化和分离过量的氧气和交换的二氧化碳气体之后，将血液在外部同轴消泡床中进一步消泡。 然后，消泡的血液在包含温度控制的循环传热流体的螺旋金属管热交换器上沿着螺旋流动路径下降同轴的环形环。 氧合消泡的血液被调节至必要的温度，从充氧器基底出血导管离开，返回到患者的身体。

公开(公告)号：US3768977A

公开(公告)日：1973-10-30

申请号：US3768977D

申请日：1972-03-31

Applicant: BRUMFIELD R ,  HOOPER A

Inventor： BRUMFIELD R ,  HOOPER A

IPC: A61M1/32 ,  A61M1/36 ,  F28F21/06 ,  A61M1/03

CPC classification number: F28F21/062 ,  A61M1/32 ,  A61M1/325 ,  A61M1/369 ,  Y10S128/03 ,  Y10S261/28

Abstract: An integral blood oxygenator and blood temperature controller combination concurrently provides blood oxygenation at a precise blood-gas temperature required by a patient. The integral combination operationally insures that the extra-corporeal circulating blood is equilibrated with oxygen gas at a patient''s required blood temperature. Multiple, small diameter aperture, equal length oxygen exchange tubes are adjacently spaced in a patterned, parallel array and secured at the pairs of tube terminus in an opposed pair of tube header plates, forming a blood-gas-energy exchange tube array. The two-phase blood-oxygengas mixture flows upward inside each of the single oxygen exchange tubes, absorbing oxygen and evolving carbon dioxide gas. Precisely temperature controlled water circulates through the gas exchange tube array around the exterior of the oxygen exchange tubes, providing precise blood temperature control during oxygenation process. By equilibrating oxygen consumption and carbon dioxide evolution at a precise blood temperature, undesired gas bubble evolution at higher random blood temperature excursions are minimized, lowering the potentiality of gas bubble evolution and gas embolism.

Abstract translation: 一体化的血液充氧器和血液温度控制器组合同时在患者所需的精确的血液 - 气体温度下提供血氧。 整体组合可操作地确保超细体循环血液在患者所需血液温度下与氧气平衡。 多个小直径的孔，等长的氧气交换管以图案化的平行阵列相邻地间隔开并且固定在相对的一对管集管板中的管对对处，形成血气 - 能 - 能 - 能量交换管阵列。 两相血氧 - 气体混合物在每个单个氧气交换管内向上流动，吸收氧气和放出二氧化碳气体。 精确控制温度的水通过氧气交换管外部的气体交换管阵列循环，在氧合过程中提供精确的血液温度控制。 通过在精确的血液温度下平衡氧气消耗和二氧化碳进化，在较高的随机血液温度偏移期间不期望的气泡发生被最小化，降低气泡发生和气体栓塞的潜力。

公开(公告)号：US3764271A

公开(公告)日：1973-10-09

申请号：US3764271D

申请日：1972-01-10

Applicant: BRUMFIELD R

Inventor： BRUMFIELD R

IPC: A61M1/32 ,  A61M1/36 ,  A61M1/03

CPC classification number: A61M1/32 ,  A61M1/322 ,  A61M1/369 ,  Y10S128/03

Abstract: A BLOOD OXYGENATOR HAS A THIN WALL HEAT EXCHANGER SHELL, HAVING A HIGHLY THERMALLY CONDUCTIVE SHELL WALL COMPOSITION, COAXIALLY ETERIORLY DISPOSED AROUND A BLOOD OXYGEN EXCHANGE TUBULAR ARRAY. THE APEX OF THE SHELL IS TIGHTLY SEALED TO THE TOP TERMINUS OF THE TUBULAR ARRAY AND THE BASE OF THE SHELL IS TIGHTLY SEALED TO AN EXTERIORLY DISPOSED COAXIAL OXYGENATED BLOOD COLLECTOR MANIFOLD. THE INTERIOR FACE OF THE SHELL WALL ADJACENT TO THE TUBULAR ARRAY IS PROVIDED WITH A FLOWING THIN FILM HEAT TRANSFER FLUID FROM A HEAT TRANSFER FLUID CIRCULATORY MEMBER HAVING A FLUID INLET AND MULTIPLE FLUID OUTLETS. THE HEAT TRANSFER FLUID EXCHANGES THERMAL ENERGY WITH THE OXYGENATED BLOOD FLOWING DOWN THE NARROW ANNULAR VOLUME DISPOSED ON THE EXTERIOR OF THE HEAT TRANSFER SHELL.

公开(公告)号：US3785380A

公开(公告)日：1974-01-15

申请号：US3785380D

申请日：1972-02-22

Applicant: BRUMFIELD R

Inventor： BRUMFIELD R

IPC: A61M1/00 ,  A61M1/36

CPC classification number: A61M1/0056 ,  A61M1/0039 ,  A61M1/0047 ,  A61M1/3627 ,  Y10S604/902

Abstract: A blood sucker is connected to the suction side of a peristaltic tube pump, evacuating blood lost by a patient at a surgical site. The air evacuated through the blood sucker when in use can be filtered through a first disposable micropore filter in the sucker, prior to contacting the blood evacuated from the surgical site. The patient blood, clean air and surgical debris are also filtered through a sucker second disposable filter, whose pore apertures are sized to remove the tissue debris from the blood flowing into the sucker. Early removal of tissue debris from patient blood in the blood sucker can slow the initiation of the blood clotting mechanism. The filtered air can decrease the microscopic air contaminants in the filtered blood, which can then be returned to the patient''s circulatory system. An integral plurality of flexible, parallel array blood conductive tubing provide wall stabilized, low turbulence blood flow from the sucker to a cardiotomy reservoir or the like, prior to returning the blood to the patient''s circulation.

Abstract translation: 吸血器连接到蠕动管泵的吸入侧，抽吸患者在外科手术部位丢失的血液。 在接触从外科手术部位排出的血液之前，在使用中通过吸血器排出的空气可以通过吸盘中的第一个一次性微孔过滤器过滤。 患者血液，清洁空气和手术碎片也通过吸盘第二一次性过滤器过滤，其中孔隙的尺寸设置成从流入吸盘的血液中去除组织碎屑。 早期从血液吸盘中的患者血液中清除组织碎屑可以减缓凝血机制的发生。 过滤的空气可以减少过滤血液中的微观空气污染物，然后可以将其返回到患者的循环系统。 在将血液返回到患者的循环之前，整体多个柔性的平行阵列导电管提供从吸盘到心脏切开术储存器等的壁稳定的低湍流血流。

公开(公告)号：US3770384A

公开(公告)日：1973-11-06

申请号：US3770384D

申请日：1971-11-29

Applicant: BRUMFIELD R

Inventor： BRUMFIELD R

IPC: A61M1/32 ,  A61M1/03

CPC classification number: A61M1/32 ,  A61M1/322 ,  Y10S128/03 ,  Y10S261/28

Abstract: Blood flows in extra-corporeal blood circulation into a blood oxygenator. The oxygenating gas enters the blood streams through a means providing oxygenating gas injection, adjacent a means providing blood inlet. The pair of means co-react to provide twophase flow of blood and oxygenating gas bubbles for the two-phase fluid flow guide. The flow guide has a multiplicity of fluid guide, solid walls of equal length, one wall uniformly closely spaced to another wall. The spaced walls are held in a boundary case by wall securing means which provide a uniform base terminus position and a uniform top terminus position for the walls. The boundary case can have a case length at least equal to the fluid guide wall lengths and greater. The fluid guide solid wall can have multiple, uniform cross section flow control channels disposed in the wall, extending normally to the base terminus and the top terminus of the wall. The flow control channels stabilize the upward flow of the two-phase blood and oxygenating gas combination. The flow control channels stabilize the gas bubbleliquid interface flow geometry, and facilitate the rapid fixation of oxygen by the blood and the release of carbon dioxide into the gas phase exiting from the top terminus of the two-phase fluid flow guide.

Abstract translation: 血液在体外血液循环中流入血液充氧器。 氧化气体通过提供含氧气体注入的装置进入血流，邻近提供血液入口的装置。 这对手段共同作用，为两相流体导流管提供血液和氧气气泡两相流。 流动引导件具有多个流体引导件，相同长度的实心壁，一个壁与另一个壁均匀地间隔开。 间隔开的墙壁通过壁固定装置保持在边界箱中，该固定装置为壁提供均匀的基座终点位置和均匀的顶端位置。 边界箱可以具有至少等于流体导向壁长度的壳体长度和更大的外壳长度。 流体引导实体壁可以具有多个均匀的横截面流动控制通道，其布置在壁中，正常延伸到壁的基端和顶端。 流量控制通道稳定两相血液和充氧气体组合的向上流动。 流动控制通道稳定气泡 - 液体界面流动几何形状，并促进氧气被血液快速固定，并且二氧化碳释放到从两相流体流动引导件顶端排出的气相中。

公开(公告)号：US3768653A

公开(公告)日：1973-10-30

申请号：US3768653D

申请日：1972-03-21

Applicant: BRUMFIELD R

Inventor： BRUMFIELD R

IPC: A61M1/32 ,  A61M1/36 ,  B01D35/14 ,  B01D31/00

CPC classification number: A61M1/3627 ,  A61M1/325 ,  A61M2206/16

Abstract: A surgical blood sucker and peristaltic pump combination discharge a three-phase mixed stream of blood, air and surgical tissue debris into a cardiotomy reservoir through a slot shape blood inlet nozzle tangentially disposed on the wall of the blood reservoir volume. The tissue debris is collected internally in the reservoir on the reservoir base filter face and the face of the conical air filter. The air, under slight pressure in the reservoir, exits from the reservoir through the air filter and a relief valve. The defoamed blood flows from the reservoir through multiple base filter plate exit apertures, into a blood oxygenator.

Abstract translation: 手术吸血器和蠕动泵组合通过切向设置在血液储存器体积的壁上的槽形血液入口喷嘴将血液，空气和手术组织碎屑的三相混合流排放到心脏切开术储存器中。 组织碎片被内部收集在储存器基座过滤器表面和锥形空气过滤器的表面上的储存器中。 空气在储存器的轻微压力下通过空气过滤器和溢流阀从储存器中排出。 消泡的血液从储存器通过多个基板过滤板出口孔流入血液充氧器。

公开(公告)号：US3747769A

公开(公告)日：1973-07-24

申请号：US3747769D

申请日：1971-08-02

Applicant: BRUMFIELD R

Inventor： BRUMFIELD R

IPC: B01D29/05 ,  B01D33/00

CPC classification number: B01D29/05 ,  A61M2202/0413 ,  B01D29/60 ,  B01D2201/06 ,  B01D2201/184 ,  Y10S55/13 ,  A61M2230/005

Abstract: An open cell, compressed, elastic plastic foam filter medium, having average diameter cell pore openings selected values ranging from 25 to 150 microns, is disposed as a planar volume in a an adjustable disposable filter press. The filter medium is disposed between a pair of rigid filter press plates, which are in turn disposed in the filter press structure. The press can provide an adjustable control means suitable for varying the average diameter of the pore openings, by varying the compression of the filter medium. A flexible, filter press case provide means of assisting blood circulation through the filter medium, and of separating air entrained in the blood in the filter press.