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公开(公告)号:US06277825B1
公开(公告)日:2001-08-21
申请号:US09357141
申请日:1999-07-20
IPC分类号: A61K3800
CPC分类号: C07K14/43504 , A61K38/00
摘要: The present invention is directed to the use of conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more &ggr;-carboxyglutamic acid residues, for the treatment of neurologic and psychiatric disorders, such as pain, e.g., as an analgesic agent.
摘要翻译: 本发明涉及使用具有10-30个氨基酸,包括优选两个或更多个γ-羧基谷氨酸残基的共同称为聚对二聚腺嘌呤肽,柯南多肽衍生物和柯南多肽嵌合体用于治疗神经病学和 精神疾病如疼痛,例如止痛剂。
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公开(公告)号:US06172041B2
公开(公告)日:2001-01-09
申请号:US09142078
申请日:1999-02-10
IPC分类号: A61K3800
CPC分类号: C07K14/43504 , A61K38/00
摘要: The present invention is directed to the use of conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more &ggr;-carboxyglutamic acid residues, for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents. Neurologic disorders and psychiatric disorders include epilepsy, convulsions, neurotoxic injury (associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, cerebrovascular accident, brain or spinal cord trauma, myocardial infarct, physical trauma, drowning, suffocation, perinatal asphyxia, or hypoglycemic events), neurodegeneration (associated with Alzheimer's disease, senile dementia, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinson's disease, Huntington's disease, Down's Syndrome, Korsakoff's disease, schizophrenia, AIDS dementia, multi-infarct dementia, Binswanger dementia and neuronal damage associated with uncontrolled seizures), chemical toxicity (such as addiction, morphine tolerance, opiate tolerance, opioid tolerance and barbiturate tolerance), pain (acute, chronic, migraine), anxiety, major depression, manic-depressive illness, obsessive-compulsive disorder, schizophrenia and mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and dystonia (movement disorder), sleep disorder, muscle relaxation and urinary incontinence. In addition, the conantokins are useful for treating HIV infection, ophthalmic indications and memory, learning or cognitive deficits.
摘要翻译: 本发明涉及使用具有10-30个氨基酸,包括优选两个或更多个γ-羧基谷氨酸残基的共同称为聚对二聚腺嘌呤肽,柯南多肽衍生物和柯南多肽嵌合体用于治疗神经病学和 精神障碍,如抗惊厥剂,神经保护剂或止痛剂。 神经系统疾病和精神疾病包括癫痫,抽搐,神经毒性损伤(与缺氧,缺氧或局部缺血的症状相关,典型地是中风,脑血管意外,脑或脊髓创伤,心肌梗塞,身体创伤,溺水,窒息,围产期窒息或 低血糖事件),神经变性(与阿尔茨海默氏病,老年性痴呆,肌萎缩性侧索硬化,多发性硬化症,帕金森病,亨廷顿病,唐氏综合征,柯萨科夫病,精神分裂症,艾滋病痴呆,多发性梗塞性痴呆,Binswanger痴呆和神经元损伤有关 不安全的癫痫发作),化学毒性(如成瘾,吗啡耐受,阿片剂耐受,阿片样物质耐受和巴比妥耐受),疼痛(急性,慢性,偏头痛),焦虑,主要抑郁症,躁狂抑郁症,强迫症,精神分裂症和 情绪障碍(如双相情感障碍,单极压抑 离子,心境恶劣和季节性有效障碍)和肌张力障碍(运动障碍),睡眠障碍,肌肉松弛和尿失禁。 此外,凝血因子可用于治疗艾滋病毒感染,眼科指征和记忆,学习或认知缺陷。
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公开(公告)号:US06399574B1
公开(公告)日:2002-06-04
申请号:US09533889
申请日:2000-03-22
IPC分类号: A61K3800
CPC分类号: C07K14/43504 , A61K38/00
摘要: The present invention is directed to the use of conantokin peptides, conantokin peptide derivatives and conantokin peptide chimeras, referred to collectively as conantokins, having 10-30 amino acids, including preferably two or more &ggr;-carboxyglutamic acid residues, for the treatment of neurologic and psychiatric disorders, such as anticonvulsant agents, neuroprotective agents or analgesic agents. Neurologic disorders and psychiatric disorders include, epilepsy, convulsions, neurotoxic injury (associated with conditions of hypoxia, anoxia or ischemia which typically follows stroke, cerebrovascular accident, brain or spinal cord trauma, myocardial infarct, physical trauma, drowning, suffocation, perinatal asphyxia, or hypoglycemic events), neurodegeneration (associated with Alzheimer's disease, senile dementia, Amyotrophic Lateral Sclerosis, Multiple Sclerosis, Parkinson's disease, Huntington's disease, Down's Syndrome, Korsakoff's disease, schizophrenia, AIDS dementia, multi-infarct dementia, Binswanger dementia and neuronal damage associated with uncontrolled seizures), chemical toxicity (such as addiction, morphine tolerance, opiate tolerance, opioid tolerance and barbiturate tolerance), pain (acute, chronic, migraine), anxiety, major depression, manic-depressive illness, obsessive-complusive disorder, schizophrenia and mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and dystonia (movement disorder), sleep disorder, muscle relaxation and urinary incontinence. In addition, the conantokins are useful for treating HIV infection, ophthalmic indications and memory, learning or cognitive deficits.
摘要翻译: 本发明涉及使用具有10-30个氨基酸,包括优选两个或更多个γ-羧基谷氨酸残基的共同称为聚对二聚腺嘌呤肽,柯南多肽衍生物和柯南多肽嵌合体用于治疗神经病学和 精神障碍,如抗惊厥剂,神经保护剂或止痛剂。 神经系统疾病和精神障碍包括癫痫,惊厥,神经毒性损伤(与缺氧,缺氧或局部缺血,脑卒中,脑或脊髓创伤,心肌梗塞,身体创伤,溺水,窒息,围产期窒息, 或低血糖事件),神经变性(与阿尔茨海默病,老年性痴呆,肌萎缩性侧索硬化症,多发性硬化症,帕金森氏病,亨廷顿病,唐氏综合征,柯萨科夫病,精神分裂症,艾滋病痴呆,多发性梗塞性痴呆,Binswanger痴呆和神经元损伤有关 不安全的癫痫发作),化学毒性(如成瘾,吗啡耐受,阿片剂耐受性,阿片样物质耐受性和巴比妥耐受性),疼痛(急性,慢性,偏头痛),焦虑,重性抑郁症,躁狂抑郁症,强迫症 - 精神分裂症 和情绪障碍(如双相情感障碍,单极痴呆) 肌力障碍和季节性有效障碍)和肌张力障碍(运动障碍),睡眠障碍,肌肉松弛和尿失禁。 此外,凝血因子可用于治疗艾滋病毒感染,眼科指征和记忆,学习或认知缺陷。
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公开(公告)号:US06268473B1
公开(公告)日:2001-07-31
申请号:US09488799
申请日:2000-01-21
申请人: Baldomero M. Olivera , Richard T. Layer , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Robert Schoenfeld , Robert M. Jones
发明人: Baldomero M. Olivera , Richard T. Layer , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Robert Schoenfeld , Robert M. Jones
IPC分类号: C07K708
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed &agr;-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The &agr;-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
摘要翻译: 本发明涉及相对短的肽(本文中称为α-芋螺毒素),长度约10-25个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且其优选包括两个 二硫键。 如本文所述,α-蛇毒毒素可用作神经肌肉阻滞剂,例如肌肉松弛剂。
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公开(公告)号:US06855805B2
公开(公告)日:2005-02-15
申请号:US09908741
申请日:2001-07-20
申请人: Baldomero M. Olivera , Richard T. Layer , J. Michael McIntosh , Jacob Scott Nielsen , Robert M. Jones
发明人: Baldomero M. Olivera , Richard T. Layer , J. Michael McIntosh , Jacob Scott Nielsen , Robert M. Jones
IPC分类号: A61K38/00 , A61K38/17 , C07K14/435 , A61K38/04
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The α-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
摘要翻译: 本发明涉及相对短的肽(本文中称为α-芋螺毒素),长度约10-25个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且其优选包括两个 二硫键。 如本文所述,α-蛇毒毒素可用作神经肌肉阻滞剂,例如肌肉松弛剂。
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公开(公告)号:US06762165B2
公开(公告)日:2004-07-13
申请号:US09749637
申请日:2000-12-28
申请人: Baldomero M. Olivera , G. Edward Cartier , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Richard T. Layer , Robert M. Jones
发明人: Baldomero M. Olivera , G. Edward Cartier , Maren Watkins , David R. Hillyard , J. Michael McIntosh , Richard T. Layer , Robert M. Jones
IPC分类号: C07K14435
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对较短的肽(本文中称为O超家族芋螺毒素),长度约20-40个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且其优选包括 两个二硫键。
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公开(公告)号:US08487075B2
公开(公告)日:2013-07-16
申请号:US13367839
申请日:2012-02-07
申请人: Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人: Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
CPC分类号: C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要: The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对短的肽(本文中称为α-芋螺毒素),长度约10-30个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且其优选包括两个 二硫键。
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公开(公告)号:US06265541B1
公开(公告)日:2001-07-24
申请号:US09219446
申请日:1998-12-23
IPC分类号: C07K1400
CPC分类号: A61K38/17 , A61K38/08 , C07K14/43504
摘要: The present invention relates to the use of &agr;-conotoxin peptides having the general formula Xaa1-Xaa2-Cys-Cys-Xaa3-Xaa4-Pro-Xaa5-Cys-Xaa6-Cys (SEQ ID NO: 1) for treating disorders regulated at neuronal nicotinic acetylcholine receptors. Such disorders include, but are not limited to, cardiovascular disorders, gastric motility disorders, urinary incontinence, nicotine addiction, mood disorders (such as bipolar disorder, unipolar depression, dysthymia and seasonal effective disorder) and small cell lung carcinoma, as well as the localization of small cell lung carcinoma. In this formula, Xaa1 is des-Xaa1, Tyr, mono-iodo-Tyr or di-iodo-Tyr, Xaa2 is any amino acid, Xaa3 is any amino acid, Xaa4 is any amino acid, Xaa5 is any amino acid and Xaa6 represents a peptide of 3-7 amino acids. Disulfide linkages exist between the first and third cysteines and the second and fourth cysteines. Pro may be replaced with hydroxy-Pro. The C-terminus may contain a hydroxyl or an amide group, preferably an amide group.
摘要翻译: 本发明涉及具有用于治疗在神经元烟碱乙酰胆碱受体调节的病症的通式的α-芋螺毒素肽的用途。 这些病症包括但不限于心血管疾病,胃动力障碍,尿失禁,尼古丁成瘾,情绪障碍(例如双相情感障碍,单极抑郁,精神抑郁和季节性有效障碍)和小细胞肺癌,以及 小细胞肺癌的定位。 在该式中,Xaa1是des-Xaa1,Tyr,单碘-Tyr或二碘-Tyr,Xaa2是任何氨基酸,Xaa3是任何氨基酸,Xaa4是任何氨基酸,Xaa5是任何氨基酸,Xaa6表示 3-7个氨基酸的肽。 第一和第三半胱氨酸与第二和第四半胱氨酸之间存在二硫键。 Pro可以用羟基替代。 C末端可以含有羟基或酰胺基,优选酰胺基。
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公开(公告)号:US09284358B2
公开(公告)日:2016-03-15
申请号:US13289494
申请日:2011-11-04
IPC分类号: A61K38/10 , A61P25/00 , C07K7/08 , A61P29/00 , A61P35/00 , C07K14/435 , C07K7/64 , A61K38/00
CPC分类号: C07K14/43504 , A61K38/00
摘要: The present invention relates conotoxin peptides that are analogs of the α-conotoxin peptide RgIA. These conotoxin peptides block the α9α10 subtype of the nicotinic acetylcholine receptor (nAChR) and can be used for treating pain, such as neuropathic pain and inflammatory pain, inflammatory disorders, such as rheumatic diseases, and in the treatment of breast cancer.
摘要翻译: 本发明涉及作为α-芋螺毒素肽RgIA的类似物的荚果毒素肽。 这些芋螺毒素肽阻断烟碱乙酰胆碱受体(nAChR)的α9α10亚型,可用于治疗疼痛,如神经性疼痛和炎性疼痛,炎性疾病如风湿性疾病,以及乳腺癌的治疗。
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公开(公告)号:US07279549B2
公开(公告)日:2007-10-09
申请号:US10895372
申请日:2004-07-21
申请人: Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
发明人: Maren Watkins , Baldomero M. Olivera , David R. Hillyard , J. Michael McIntosh , Robert M. Jones
IPC分类号: A61K38/10 , A61K38/17 , C07K7/08 , C07K714/435
CPC分类号: C07K14/43504 , A61K38/00 , C07K7/08 , C07K9/00 , Y10S530/855 , Y10S530/857
摘要: The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对短的肽(本文中称为α-芋螺毒素),长度约10-30个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且其优选包括两个 二硫键。
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