摘要:
Thee present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA via replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or creating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要:
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要:
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要:
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
摘要:
A system and method are provided to intelligently limit the frequency at which automated or semi-automated trading tools move or re-price orders in an exchange order book. A tolerance may be input that limits when one or more orders in the exchange order book are moved from one price to another. The system and method assist in reducing the number of orders that are entered into the system which can lead to reduced exchange transaction fees, lost queue position, and reduce network bandwidth consumption.
摘要:
Method and systems of registering participants for an event at an event site are disclosed. Identification data specific to a participant encoded on a first token object is read with a mobile computing device. A query is generated from the mobile computing device to a remote event registration system for prior registration data based upon at least a subset of the received identification data. The prior registration data is received on the mobile computing device. A first subset of the prior registration data is transmitted to a local event registration system, and a payment success indicator is received upon successful payment processing. Registrant identification data is generated by the local event registration system in response to recording the first subset of the prior registration data and the payment success indicator.
摘要:
A method and apparatus for forming a transversely curved or formed strip of material which can be cut to length for use in a fabric for coverings for architectural opening includes a supply role of a flexible fabric strip material that is sequentially passed through a heating chamber with an elongated upwardly convex extrusion across which the strip material is drawn and a cooling station before being wrapped on a take-up drum. The apparatus includes driven rollers about which the strip material passes and the strip material is exposed to tension detectors and controlled temperatures such that the strip material formed in the apparatus is uniform along its length.
摘要:
A versatile system which includes a display unit by which a plurality of image works selected from photographs, paintings, newspaper articles, pictures, images, prints, designs, sports memorabilia, certificates, awards, and diplomas may be viewed simultaneously or individually, as selected by the viewer. A display unit stores a plurality of image works for selective viewing by an observer by virtue of each image works being mounted on a slidable carrier, which may be slid within a framework to enable or disable viewing of image works which may be disposed behind a given slidable carrier.
摘要:
A slat for use in a covering for an architectural opening is made from a base material of binder and matrix fibers which are formed into a nonwoven material by melting at least a portion of the binder fibers to thermally bond the binder and matrix fibers. A coating of resin is then applied to the thermally bonded base before the composite material is passed through a forming apparatus where the material is heated over a convex support having the desired curvature for the slat and subsequently cooled.
摘要:
A system and method are provided to intelligently limit the frequency at which automated or semi-automated trading tools move or re-price orders in an exchange order book. A tolerance may be input that limits when one or more orders in the exchange order book are moved from one price to another. The system and method assist in reducing the number of orders that are entered into the system which can lead to reduced exchange transaction fees, lost queue position, and reduce network bandwidth consumption.