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公开(公告)号：US20100093716A1
公开(公告)日：2010-04-15
申请号：US12438793
申请日：2007-08-29
申请人： Barbara A. Gilchrest , Mark S. Eller , Angela N. Koehler , Olivia M. McPherson , Christopher S. Neumann , Timothy A. Lewis
发明人： Barbara A. Gilchrest , Mark S. Eller , Angela N. Koehler , Olivia M. McPherson , Christopher S. Neumann , Timothy A. Lewis
IPC分类号： A61K31/5386 , C07D498/20 , A61P35/04
CPC分类号： C07D498/04
摘要： The present invention provides, inter alia, compositions and methods for treating various diseases and disorders in a mammal by administering to a mammal in need an effective amount of a composition comprising a non-DNA small molecule that binds WRN, such as members of the spirooxindole (SPOX) class.
摘要翻译： 本发明尤其提供了通过向需要的哺乳动物施用有效量的包含结合WRN的非DNA小分子的组合物（例如螺环吲哚的成员）来治疗哺乳动物各种疾病和病症的组合物和方法 （SPOX）类。
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公开(公告)号：US20080221052A1
公开(公告)日：2008-09-11
申请号：US11569243
申请日：2005-05-19
IPC分类号： A61K31/70 , C12Q1/68 , G01N33/574 , A61P43/00 , C12Q1/02 , G01N33/566
CPC分类号： G01N33/5041 , C12N15/1137 , C12N2310/13 , G01N33/5008 , G01N33/5011 , G01N33/6875 , G01N2510/00
摘要： The use of modulators of WRN is described. Activators of WRN may be used to induce growth arrest, apoptosis or proliferative senescence, whereas inhibitors of WRN may be used to reduce growth arrest, apoptosis or proliferative senescence. Methods of identifying modulators of WRN are also described.
摘要翻译： 描述了使用WRN的调制器。 WRN的活化剂可用于诱导生长停滞，凋亡或增殖衰老，而WRN抑制剂可用于减少生长停滞，细胞凋亡或增殖衰老。 还描述了识别WRN调节剂的方法。
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公开(公告)号：US20100286247A1
公开(公告)日：2010-11-11
申请号：US11909435
申请日：2006-04-04
CPC分类号： C12N15/115
摘要： Alterations in the structure of telomeres lead to modulation in the redox state of the cell. Substances which mimic destabilized telomeres, such as t-oligos, have a protective effect on future exposure of a cell to oxidative stress.
摘要翻译： 端粒结构的变化导致细胞氧化还原状态的调节。 模拟不稳定端粒的物质，如t-oligos，对未来细胞暴露于氧化应激具有保护作用。
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公开(公告)号：US20110237654A1
公开(公告)日：2011-09-29
申请号：US13008785
申请日：2011-01-18
IPC分类号： A61K31/7088 , C12N5/095 , C07H21/04 , A61P35/00 , A61P35/02
CPC分类号： A61K31/7088
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful for treating other cancers, such as for example pancreatic cancer and eradicating cancer stem cells.
摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增殖性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症，例如胰腺癌和根除癌症干细胞。
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公开(公告)号：US20100249218A1
公开(公告)日：2010-09-30
申请号：US12715242
申请日：2010-03-01
IPC分类号： A61K31/7088 , C07H21/04 , A61P35/00
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。
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6.发明授权Inhibition of apoptosis in keratinocytes by a ligand of p75 nerve growth factor receptor 失效通过p75神经生长因子受体的配体抑制角质细胞凋亡公开(公告)号：US07196055B2
公开(公告)日：2007-03-27
申请号：US09018194
申请日：1998-02-04
申请人： Barbara A. Gilchrest , Mina Yaar , Mark S. Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark S. Eller
CPC分类号： A61K8/64 , A61K31/713 , A61K38/12 , A61K38/185 , A61Q7/00 , C07K7/64 , C12N15/113 , C12N15/1138 , C12N2310/315
摘要： Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.
摘要翻译： 公开了控制或操纵黑素细胞和角化细胞死亡的方法。 特别地，公开了一种防止由于脊椎动物中的损伤引起的表皮黑素细胞细胞损失的方法。 还公开了一种在脊椎动物中诱导毛发生长的方法，在脊椎动物中诱发毛发颜色的方法，在脊椎动物中诱导肤色的方法，治疗个体中的秃发的方法以及治疗斑秃的方法 个人。
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公开(公告)号：US07033829B2
公开(公告)日：2006-04-25
申请号：US10122633
申请日：2002-04-12
申请人： Barbara A. Gilchrest , Mark S. Eller , Mina Yaar
发明人： Barbara A. Gilchrest , Mark S. Eller , Mina Yaar
IPC分类号： C12Q3/00
CPC分类号： A61K31/711 , A61K31/7125 , A61K41/0057 , A61K48/00 , A61K48/005 , C12N15/85 , C12N2830/001
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.
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公开(公告)号：US08183222B2
公开(公告)日：2012-05-22
申请号：US12715242
申请日：2010-03-01
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。
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公开(公告)号：US20100222419A1
公开(公告)日：2010-09-02
申请号：US12709378
申请日：2010-02-19
IPC分类号： A61K31/7088 , A61P35/00
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增殖性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。
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公开(公告)号：US20090209747A1
公开(公告)日：2009-08-20
申请号：US12275089
申请日：2008-11-20
IPC分类号： A61K31/7088 , C07H21/04
CPC分类号： A61K31/711 , A61K31/7088 , A61K31/7125 , A61K31/713
摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.
摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。
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