利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.032 秒)

    Small molecule printing
    2.
    发明授权
    Small molecule printing 失效
    小分子印刷

    公开(公告)号：US06824987B1

    公开(公告)日：2004-11-30

    申请号：US09567910

    申请日：2000-05-10

    申请人： Stuart L. Schreiber ,  Gavin MacBeath ,  Angela N. Koehler ,  Paul Hergenrother ,  Kristopher M. Depew

    发明人： Stuart L. Schreiber ,  Gavin MacBeath ,  Angela N. Koehler ,  Paul Hergenrother ,  Kristopher M. Depew

    IPC分类号： G01N3353

    CPC分类号： G01N31/00 ,  B01J19/0046 ,  B01J2219/00387 ,  B01J2219/00454 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00533 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/0072 ,  C07B2200/11 ,  C07C311/49 ,  C40B30/04 ,  C40B40/04 ,  C40B50/14 ,  C40B60/14 ,  G01N33/54353 ,  Y10S436/809

    摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support, wherein the density of the array of compounds is at least 1000 spots per cm2. In particularly preferred embodiments, these compounds are attached to the solid support through a covalent interaction. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with a selected chemical moiety capable of interacting with a desired chemical compound to form an attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; and (3) delivering said one or more types of compounds to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm2. In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest comprising: (1) providing an array of compounds, wherein the array has a density of at least 1000 spots per cm2; (2) contacting the array with one of more types of biological macromolecules of interest; and (3) determining the interaction of specific small molecule-biological macromolecule partners.

    摘要翻译： 本发明提供了有助于鉴定能够与感兴趣的生物大分子相互作用的化合物的组合物和方法。 在一个方面，提供了包含连接到固体支持物上的一种或多种类型化学化合物的阵列的组合物，其中化合物阵列的密度为至少1000个斑点/ cm 2。 在特别优选的实施方案中，这些化合物通过共价相互作用连接到固体支持物上。 通常，这些本发明的阵列通过以下方式产生：（1）提供固体支持物，其中所述固体支持物用能够与所需化学化合物相互作用以形成附着物的选定化学部分官能化; （2）提供待连接到固体支持物上的一种或多种类型化合物的一种或多种溶液; 和（3）将所述一种或多种类型的化合物递送到固体支持物，由此形成阵列，并且所述化合物阵列的密度至少为1000个点/ cm 2。 另一方面，本发明提供了利用这些阵列来识别感兴趣的生物大分子的小分子配偶体的方法，包括：（1）提供化合物阵列，其中阵列的密度至少为1000个点/ cm 2 ; （2）使阵列与感兴趣的多种生物大分子之一接触; 和（3）确定特定小分子 - 生物大分子伴侣的相互作用。

    SMALL MOLECULE PRINTING
    3.
    发明申请
    SMALL MOLECULE PRINTING 审中-公开
    小分子印刷

    公开(公告)号：US20120021933A1

    公开(公告)日：2012-01-26

    申请号：US13094609

    申请日：2011-04-26

    申请人： Seung Bum Park ,  David Barnes-Seeman ,  Angela N. Koehler ,  Stuart L. Schreiber

    发明人： Seung Bum Park ,  David Barnes-Seeman ,  Angela N. Koehler ,  Stuart L. Schreiber

    IPC分类号： C40B30/04 ,  C40B50/18 ,  C40B60/08 ,  C40B40/04

    CPC分类号： C40B60/14 ,  B01J19/0046 ,  B01J2219/00387 ,  B01J2219/00454 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00533 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/0072 ,  C07B2200/11 ,  C07C311/49 ,  C40B30/04 ,  C40B40/04 ,  C40B50/14 ,  G01N33/54353 ,  Y10S436/809

    摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support, wherein the density of the array of compounds is at least 1000 spots per cm2. In particularly preferred embodiments, these compounds are attached to the solid support through a covalent interaction. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with a selected chemical moiety capable of interacting with a desired chemical compound to form an attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; and (3) delivering said one or more types of compounds to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm2. In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest comprising: (1) providing an array of compounds, wherein the array has a density of at least 1000 spots per cm2; (2) contacting the array with one of more types of biological macromolecules of interest; and (3) determining the interaction of specific small molecule-biological macromolecule partners.

    摘要翻译： 本发明提供了有助于鉴定能够与感兴趣的生物大分子相互作用的化合物的组合物和方法。 在一个方面，提供了包含连接到固体支持物上的一种或多种类型化学化合物的阵列的组合物，其中化合物阵列的密度为每cm 2至少1000个点。 在特别优选的实施方案中，这些化合物通过共价相互作用连接到固体支持物上。 通常，这些本发明的阵列通过以下方式产生：（1）提供固体支持物，其中所述固体支持物用能够与所需化学化合物相互作用以形成附着物的选定化学部分官能化; （2）提供待连接到固体支持物上的一种或多种类型化合物的一种或多种溶液; 和（3）将所述一种或多种类型的化合物递送到固体支持物，由此形成阵列，并且化合物阵列的密度至少为1000个点/ cm2。 在另一方面，本发明提供了利用这些阵列鉴定感兴趣的生物大分子的小分子伴侣的方法，包括：（1）提供化合物阵列，其中阵列的密度至少为1000个点/ cm2; （2）使阵列与感兴趣的多种生物大分子之一接触; 和（3）确定特定小分子 - 生物大分子伴侣的相互作用。

    SMALL MOLECULE PRINTING
    4.
    发明申请
    SMALL MOLECULE PRINTING 审中-公开
    小分子印刷

    公开(公告)号：US20090221433A1

    公开(公告)日：2009-09-03

    申请号：US12159481

    申请日：2007-01-03

    申请人： David W. Barnes ,  Angela N. Koehler ,  James E. Bradner ,  Ralph Mazitschek ,  Stuart L. Schreiber

    发明人： David W. Barnes ,  Angela N. Koehler ,  James E. Bradner ,  Ralph Mazitschek ,  Stuart L. Schreiber

    IPC分类号： C40B30/04 ,  C40B40/04 ,  C40B50/12

    CPC分类号： G01N33/6803 ,  B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00626 ,  B01J2219/00659 ,  B01J2219/0072 ,  B01J2219/0074 ,  C40B30/04 ,  C40B40/04 ,  C40B80/00 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54353 ,  G01N33/547 ,  G01N33/552 ,  G01N33/553

    摘要： The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support using isocyanate or isothiocyanate chemistry, wherein the density of the array of compounds is at least 1000 spots per cm2. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with an isocyanate or isothiocyanate moiety capable of interacting with a desired chemical compound to form a covalent attachment; (2) providing one or more solutions of one or more types of compounds to be attached to the solid support; (3) delivering said one or more types of compounds to the solid support; and (4) catalyzing the attachment of the compound to the solid support, whereby an array is formed and the array of compounds has a density of at least 1000 spots per cm2. In another aspect, the present invention provides methods for utilizing these arrays to identify small molecule partners for biological macromolecules of interest.

    摘要翻译： 本发明提供了有助于鉴定能够与感兴趣的生物大分子相互作用的化合物的组合物和方法。 在一个方面，提供了一种组合物，其包含使用异氰酸酯或异硫氰酸酯化学连接到固体支持物上的一种或多种类型化学化合物的阵列，其中化合物阵列的密度为每cm 2至少1000个点。 通常，这些本发明的阵列通过以下方式产生：（1）提供固体支持物，其中所述固体支持物用能够与所需化学化合物相互作用以形成共价连接的异氰酸酯或异硫氰酸酯部分官能化; （2）提供待连接到固体支持物上的一种或多种类型化合物的一种或多种溶液; （3）将所述一种或多种类型的化合物递送至固体支持物; 和（4）催化化合物与固体支持物的连接，由此形成阵列，并且化合物阵列的密度至少为1000个点/ cm2。 在另一方面，本发明提供了利用这些阵列鉴定感兴趣的生物大分子的小分子伴侣的方法。