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    METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES
    4.
    发明申请
    METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES 审中-公开
    使用寡核苷酸抑制细胞生长的方法

    公开(公告)号：US20110237654A1

    公开(公告)日：2011-09-29

    申请号：US13008785

    申请日：2011-01-18

    申请人： Barbara A. Gilchrest ,  Mark S. Eller

    发明人： Barbara A. Gilchrest ,  Mark S. Eller

    IPC分类号： A61K31/7088 ,  C12N5/095 ,  C07H21/04 ,  A61P35/00 ,  A61P35/02

    CPC分类号： A61K31/7088

    摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful for treating other cancers, such as for example pancreatic cancer and eradicating cancer stem cells.

    摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增殖性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症，例如胰腺癌和根除癌症干细胞。

    Method to inhibit cell growth using oligonucleotides
    6.
    发明授权
    Method to inhibit cell growth using oligonucleotides 失效
    使用寡核苷酸抑制细胞生长的方法

    公开(公告)号：US08183222B2

    公开(公告)日：2012-05-22

    申请号：US12715242

    申请日：2010-03-01

    申请人： Barbara A. Gilchrest ,  Mark S. Eller

    发明人： Barbara A. Gilchrest ,  Mark S. Eller

    IPC分类号： A61K48/00 ,  C07H21/04 ,  C07H21/02 ,  C12N15/85

    CPC分类号： A61K31/711 ,  A61K31/7088 ,  A61K31/7125 ,  A61K31/713

    摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.

    摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。

    METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES
    7.
    发明申请
    METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES 审中-公开
    使用寡核苷酸抑制细胞生长的方法

    公开(公告)号：US20090209747A1

    公开(公告)日：2009-08-20

    申请号：US12275089

    申请日：2008-11-20

    申请人： Barbara A. Gilchrest ,  Mark S. Eller

    发明人： Barbara A. Gilchrest ,  Mark S. Eller

    IPC分类号： A61K31/7088 ,  C07H21/04

    CPC分类号： A61K31/711 ,  A61K31/7088 ,  A61K31/7125 ,  A61K31/713

    摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.

    摘要翻译： 描述了通过向受影响的哺乳动物（例如，人）施用有效量的组合物来治疗过度增殖性疾病（包括癌症）的方法，所述有效量的组合物包含与人类共享至少33％但小于100％的核苷酸序列同一性的一种或多种寡核苷酸 端粒突出重复。 治疗或预防影响上皮细胞的过度增殖性疾病或癌前病症的方法，例如牛皮癣，特应性皮炎或其他上皮细胞的过度增生性疾病，以及降低光老化或氧化应激或预防或降低其发生可能性的方法 皮肤癌的发展也被公开。 组合物和方法也可用于治疗其它癌症。

    Method to inhibit cell growth using oligonucleotides
    8.
    发明授权
    Method to inhibit cell growth using oligonucleotides 失效

    公开(公告)号：US07033829B2

    公开(公告)日：2006-04-25

    申请号：US10122633

    申请日：2002-04-12

    申请人： Barbara A. Gilchrest ,  Mark S. Eller ,  Mina Yaar

    发明人： Barbara A. Gilchrest ,  Mark S. Eller ,  Mina Yaar

    IPC分类号： C12Q3/00

    CPC分类号： A61K31/711 ,  A61K31/7125 ,  A61K41/0057 ,  A61K48/00 ,  A61K48/005 ,  C12N15/85 ,  C12N2830/001

    摘要： Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.

    Stimulation of tanning by DNA fragments or single-stranded DNA
    10.
    发明授权
    Stimulation of tanning by DNA fragments or single-stranded DNA 失效
    通过DNA片段或单链DNA刺激鞣制

    公开(公告)号：US5470577A

    公开(公告)日：1995-11-28

    申请号：US88251

    申请日：1993-07-07

    申请人： Barbara A. Gilchrest ,  Mina Yaar ,  Mark Eller

    发明人： Barbara A. Gilchrest ,  Mina Yaar ,  Mark Eller

    IPC分类号： A61K8/60 ,  A61K45/06 ,  A61Q19/04 ,  A61K37/22 ,  A61K9/50

    CPC分类号： A61Q19/04 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7048 ,  A61K45/06 ,  A61K8/606

    摘要： A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.

    摘要翻译： 公开了一种增加哺乳动物皮肤色素沉着的方法，以及保护哺乳动物皮肤免受紫外线损害。 还公开了增加哺乳动物细胞中色素沉积的方法，以及增强哺乳动物黑素细胞中黑色素产生的方法。 另外公开了本发明方法中有用的制剂。 所述方法包括在脂质体制剂或其它合适的载体中向表皮或细胞施用单链或双链或二者或脱氧核苷酸的混合物的DNA片段。 该制剂包括DNA片段或脱氧核苷酸以及合适的递送载体，例如脂质体。