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    Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system
    1.
    发明授权
    Integrated centrifugal blood pump-oxygenator, an extracorporeal life support system and a method of de-bubbling and priming an extracorporeal life support system 有权
    综合离心式血液泵 - 氧合器，体外生命支持系统和一种去冒泡和引发体外生命支持系统的方法

    公开(公告)号：US08496874B2

    公开(公告)日：2013-07-30

    申请号：US11999707

    申请日：2007-12-05

    申请人： Barry N. Gellman ,  Andrew Koert ,  Zhongjun Wu ,  Juntao Zhang ,  Bartley P. Griffith

    发明人： Barry N. Gellman ,  Andrew Koert ,  Zhongjun Wu ,  Juntao Zhang ,  Bartley P. Griffith

    IPC分类号： A61M1/00 ,  A61M37/00

    CPC分类号： A61M1/1698 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1015 ,  A61M1/1031 ,  A61M1/1036 ,  A61M1/1086 ,  A61M1/262 ,  A61M1/267 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/3334

    摘要： An integrated centrifugal blood pump-oxygenator (1) which has a housing (2) with a top (3) having a blood inlet (4), a blood outlet (5) and a gas inlet (6), and a bottom (7) having a rotational body (8) being rotatably arranged in a rotor-housing (9) of the bottom (7). The integrated centrifugal blood pump-oxygenator (1) further has an oxygenator membrane (10) provided in an interior (11) of the housing (2), wherein in the operation state oxygen (12) is transferred from the gas inlet (6) through the oxygenator membrane (10) to a gas outlet (13) and blood (14) is brought in direct contact with the oxygenator membrane (10) by pumping the blood (14) with the rotational body (8) from the blood inlet (4) to the blood outlet (5). The rotational body (8) is magnetically journalled in a contact-free manner with respect to the rotor-housing (9). There is an extracorporeal life support system (1000), and a method of de-bubbling and priming a extracorporeal life support system (1000).

    摘要翻译： 一种具有壳体（2）的集成离心血泵 - 氧合器（1），具有血液入口（4）的顶部（3），血液出口（5）和气体入口（6）以及底部（7） ）具有可旋转地布置在底部（7）的转子壳体（9）中的旋转体（8）。 集成离心血泵 - 氧合器（1）还具有设置在壳体（2）的内部（11）中的氧合器膜（10），其中在操作状态下，氧气（12）从气体入口（6）传送， 通过氧合膜（10）到气体出口（13），并且血液（14）通过从血液入口泵送具有旋转体（8）的血液（14）而与氧合器膜（10）直接接触 4）到血液出口（5）。 旋转体（8）相对于转子壳体（9）以无接触的方式磁性地支承。 有一个体外生命支持系统（1000），一种去冒泡和引发体外生命支持系统的方法（1000）。

    Self-expanding cannula
    2.
    发明授权
    Self-expanding cannula 有权

    公开(公告)号：US10912920B2

    公开(公告)日：2021-02-09

    申请号：US14905073

    申请日：2014-07-17

    申请人： Zhongjun Wu ,  Bartley P. Griffith ,  Jun Ding

    发明人： Zhongjun Wu ,  Bartley P. Griffith ,  Jun Ding

    IPC分类号： A61M25/00 ,  A61M1/36 ,  A61M25/04

    摘要： Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (SLC) configurations and double lumen cannula (DLC) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patients body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patients blood vessel or a portion of the system inserted into the patients blood vessel) from collapsing as fluid is drained from the patient.

    USE OF AEROSOLIZED CYCLOSPORINE FOR PREVENTION AND TREATMENT OF PULMONARY DISEASE
    3.
    发明申请
    USE OF AEROSOLIZED CYCLOSPORINE FOR PREVENTION AND TREATMENT OF PULMONARY DISEASE 审中-公开
    使用环糊精用于预防和治疗肺炎的药物

    公开(公告)号：US20120189672A1

    公开(公告)日：2012-07-26

    申请号：US13439187

    申请日：2012-04-04

    申请人： Aldo T. Iacono ,  Bartley P. Griffith

    发明人： Aldo T. Iacono ,  Bartley P. Griffith

    IPC分类号： A61K38/13 ,  A61P11/00 ,  A61P29/00 ,  A61K9/14 ,  A61P37/06

    CPC分类号： A61K38/13 ,  A61K9/0073 ,  Y10T428/2982 ,  A61K2300/00

    摘要： The present invention relates to methods and compositions for prevention of graft rejection in lung transplant recipients and for treatment of subjects with pulmonary disorders. Specifically, the methods and compositions of the invention provide a means for inhibiting immune response mediated inflammatory processes in the lungs. The method of the invention comprises the administration of aerosolized cyclosporine for prevention of acute and/or chronic refractory rejection in lung transplant patients. The invention further provides for the use of aerosolized cyclosporine to treat subjects having immunologically mediated inflammatory pulmonary disorders including, but not limited to, asthma, cystic fibrosis, idiopathic pulmonary fibrosis, chronic bronchitis and allergic rhinitis. The present invention, by enabling a method for the use of aerosolized cyclosporine for inhibiting pulmonary inflammation leading to prevention of graft rejection and treatment of pulmonary disorders, provides a safer and less toxic treatment than those methods that utilize systemic administration of cyclosporine.

    摘要翻译： 本发明涉及用于预防肺移植受体中的移植物排斥反应的方法和组合物以及用于治疗患有肺部疾病的受试者。 具体地，本发明的方法和组合物提供了一种用于抑制肺中免疫应答介导的炎症过程的手段。 本发明的方法包括施用雾化的环孢菌素以预防肺移植患者的急性和/或慢性难治性排斥反应。 本发明还提供了使用雾化的环孢菌素来治疗具有免疫介导的炎症性肺病的受试者，包括但不限于哮喘，囊性纤维化，特发性肺纤维化，慢性支气管炎和过敏性鼻炎。 本发明通过实现气雾化环孢菌素用于抑制肺部炎症导致预防移植物排斥反应和治疗肺部疾病的方法，提供比利用全身施用环孢菌素的那些方法更安全和更少毒性的治疗方法。

    BLOOD COAGULATION INDUCING POLYMER HYDROGEL
    4.
    发明申请
    BLOOD COAGULATION INDUCING POLYMER HYDROGEL 审中-公开
    血液凝聚诱导聚合物水凝胶

    公开(公告)号：US20120009242A1

    公开(公告)日：2012-01-12

    申请号：US13127152

    申请日：2009-11-03

    申请人： Brendan J. Casey ,  Peter Kofinas ,  Adam Behrens ,  Trevor A. Snyder ,  Bartley P. Griffith

    发明人： Brendan J. Casey ,  Peter Kofinas ,  Adam Behrens ,  Trevor A. Snyder ,  Bartley P. Griffith

    IPC分类号： A61K31/785 ,  A61L15/24 ,  A61P7/04 ,  A61L15/44 ,  A61L31/12 ,  A61L31/16 ,  C08F226/02 ,  A61L15/58

    CPC分类号： A61L15/24 ,  A61L15/44 ,  A61L15/60 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/418 ,  A61L2300/43 ,  C08L33/26

    摘要： The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated.

    摘要翻译： 本申请被描述为合成的聚合物水凝胶基材料，其能够主动地诱导身体在血液或无细胞血浆中的天然止血凝血过程。 本发明提供了能够诱导凝血并递送用于止血或伤口护理应用的治疗剂的含伯胺聚合物水凝胶的开发，以及形成能够诱导凝血过程的含伯胺聚合物水凝胶的方法。 含伯胺聚合物水凝胶能够实现与生物基止血剂相同的最终结果，没有疾病传播或免疫应答的先天风险，并且价格仅为一小部分。 此外，由于其固有的基于水凝胶的设计，该材料具有阻止失血的能力，同时以受控的方式递送治疗剂，这可能彻底改变了治疗伤口的方式。