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    METHODS FOR ASSESSING THE RISK OF ADVERSE EVENTS UPON TREATMENT WITH IGG4 ANTIBODIES
    8.
    发明申请
    METHODS FOR ASSESSING THE RISK OF ADVERSE EVENTS UPON TREATMENT WITH IGG4 ANTIBODIES 审中-公开
    IGG4抗体治疗不良事件的风险评估方法

    公开(公告)号：US20110086366A1

    公开(公告)日：2011-04-14

    申请号：US12918768

    申请日：2009-02-20

    申请人： Aran Frank Labrijn ,  Janine Schuurman ,  Jan Van De Winkel ,  Paul Parren

    发明人： Aran Frank Labrijn ,  Janine Schuurman ,  Jan Van De Winkel ,  Paul Parren

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6854 ,  G01N2800/50 ,  Y02A50/53

    摘要： The invention relates to methods and kits for assessing the risk, for an individual, of developing an adverse event upon treatment with a therapeutic antibody which is capable of Fab-arm exchange, said method comprising the steps of: a) providing a sample from an individual who is a candidate for treatment with said therapeutic antibody, b) assaying said sample for the presence of circulating IgG4 antibodies that binds an antigen known or suspected to be associated with a causative agent of said adverse event, and c) assessing, on the basis of the outcome of the assay of step b), the risk that the individual will develop said adverse event upon treatment with the therapeutic antibody, wherein the risk of development of said adverse event increases with increased level of said circulating IgG4 antibodies.

    摘要翻译： 本发明涉及用于评估个体在用能够进行Fab-臂交换的治疗性抗体治疗后发展不良事件的风险的方法和试剂盒，所述方法包括以下步骤：a）从 作为用所述治疗性抗体治疗的候选者的个体，b）测定所述样品是否存在结合已知或怀疑与所述不良事件的致病因子相关联的抗原的循环IgG4抗体，以及c） 步骤b）的测定结果的基础，个体在用治疗性抗体治疗后将发展出所述不良事件的风险，其中所述不良事件发展的风险随着所述循环IgG4抗体水平的增加而增加。